Menopause and metabolic syndrome in obese individuals with binge eating disorder

Abstract

Menopausal transition has been associated with emergence of metabolic abnormalities, which may increase risk for chronic medical conditions in women. This study compared metabolic function between premenopausal women (n = 152), postmenopausal women (n = 88), and men (n = 98) recruited for treatment studies for obesity co-occurring with binge eating disorder (BED), a high risk population for developing metabolic syndrome (MetS). Postmenopausal women were more likely than premenopausal women to show elevated total cholesterol (OR = 2.75; 95% CI = 1.56–4.80) and poor glycemic control (OR = 2.92; 95% CI = 1.32–6.33), but were more likely to have lower HDL levels (OR = 0.36; 95% CI = 0.19–0.68). These became non-significant after adjusting for age. Both pre- and postmenopausal women were less likely than age-matched men to show elevated levels of triglycerides (OR = 0.27; 95% CI = 0.13–0.53 [postmenopausal], OR = 0.29; 95% CI = 0.16–0.53 [premenopausal]), blood pressure (OR = 0.48; 95% CI = 0.25–0.91 [postmenopausal], OR = 0.40; 95% CI = 0.23–0.69 [premenopausal]), and less likely to have MetS (OR = 0.41; 95% CI = 0.21–0.78 [postmenopausal], OR = 0.46; 95% CI = 0.27–0.79 [premenopausal]). Premenopausal women were also less likely to have elevated fasting glucose level (OR = 0.50; 95% CI = 0.26–0.97) than age-matched men. Among obese women with BED, aging may have a more profound impact on metabolic abnormalities than menopause, suggesting the importance of early intervention of obesity and symptoms of BED. Active monitoring of metabolic function in obese men with BED may also be critical.

Sex Differences in Obesity and Mental Health

“…The second study examined the possible role of menopause in the relationship between metabolic syndrome and binge eating disorder [57]. They studied 152 premenopausal women, 88 postmenopausal women, and 98 age-matched men from a treatment study sample.…”

Preliminary examination of metabolic syndrome response to motivational interviewing for weight loss as compared to an attentional control and usual care in primary care for individuals with and without binge-eating disorder

“…In fact, a longitudinal study reported individuals who reported binge eating were at greater risk for newly diagnosed metabolic syndrome symptoms, compared with non-binge eaters (Hudson et al, 2010). Consequently, individuals with BED and excess weight have been underscored as a significant subgroup with increased risk for developing metabolic syndrome (Abraham, Massaro, Hoffmann, Yanovski, & Fox, 2014; Barnes et al, 2011; Blomquist et al, 2012; Hudson, Hiripi, Pope, & Kessler, 2007; Mitchell, 2015; Sheehan & Herman, 2015; Udo, McKee, White, Masheb, Barnes, & Grilo, 2014a; Udo, McKee, White, Masheb, Barnes, & Grilo, 2014b). It is critical, therefore, to examine these individuals, with excess weight, metabolic syndrome, and binge eating disorder, as they may be at extreme risk for harmful health-related consequences.…”

Medical comorbidity and medical complications associated with binge‐eating disorder

“…In examining a large cohort in a Finnish sample, Reavurori et al compared patients that had been seen for eating disorders treatment ( n = 2,342) versus control participants ( n = 9,368), and found strong support for an association between type II diabetes and clinically significant binge eating. Udo et al in 2014 in studying 152 treatment‐seeking obese found that the development of the metabolic syndrome abnormalities seemed to be best explained by aging as the most powerful risk factor rather than menopause, while Adani et al, also in 2014, in studying obese adolescents including those with subclinical BED symptoms found no difference in serum glucose levels between those affected and those unaffected. Most recently, Çelik et al reported that among 152 patients age 18–75 with type II diabetes, those with versus those without BED evidenced no difference in HgA1c.…”