Oral health is constantly shaped by the cross-talk between behavioral, biological, and social forces. Menopause is that time in a woman's life when menstrual cycles cease by reduced secretion of the ovarian hormones, such as, estrogen and progesterone. Diseases of the mouth itself are the most common reasons for pain and discomfort in the mouth. However, there are certain situations where oral symptoms are caused as a result of systemic diseases. This review article has emphasized on the diverse oral presentations of postmenopausal women by descriptive analysis of various underlying mechanisms associated with these conditions. Dentists should be aware of the possible association of menopause and various oral health problems.