Menopause-related differences in inflammation markers and their relationship to body fat distribution and insulin-stimulated glucose disposal

Sites, Cynthia K.; Toth, Michael J.; Cushman, Mary; L'Hommedieu, Georgia D.; Tchernof, André; Tracy, Russell P.; Poehlman, Éric T.

doi:10.1016/s0015-0282(01)02934-x

Cited by 134 publications

(97 citation statements)

References 29 publications

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“…In a recent clinical trial of 28 women and 7 men (averages age 38 years old), increased fiber intake, either through a diet naturally high in fiber or through fiber supplementation, was associated with significant decreases in hs-CRP levels [23].The study population in the present study was older (mean age = 62 years) and exclusively female, with an average hs-CRP of 2.0 mg/L which may account for discrepant findings. Additionally, Hs-CRP may differ by menopausal status, however, a recent study did not support this hypothesis [51]. Future studies should further examine gender, age, and ethnic differences in these associations.…”

Section: Discussionmentioning

confidence: 90%

Association between dietary fiber and markers of systemic inflammation in the Women's Health Initiative Observational Study

et al. 2008

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Objective-Systemic inflammation may play an important role in the development of atherosclerosis, type 2 diabetes, and some cancers. Few studies have comprehensively assessed the direct relationships between dietary fiber and inflammatory cytokines, especially in minority populations. Using baseline data from 1,958 postmenopausal women enrolled in the Women's Heath Initiative Observational Study, we examined cross-sectional associations between dietary fiber intake and markers of systemic inflammation (including serum C-reactive protein (hs-CRP), interleukin 6 (IL-6), and tumor necrosis factor α receptor 2 (TNF-α-R2)), as well as differences in these associations by ethnicity.Method-Multiple linear regression models were used to assess the relationship between fiber intake and makers of systemic inflammation.Results-After adjustment for covariates, intake of dietary fiber were inversely associated with both IL-6 (P values for trend were 0.01 for total fiber, 0.004 for soluble fiber, and 0.001 for insoluble fiber) and TNF-α-R2 (P values for trend were 0.002 for total, 0.02 for soluble, and <0.001 for insoluble fiber). Although the sample sizes were small in minority Americans, results were generally Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Conclusions-These findings lend support to the hypothesis that a high-fiber diet is associated with lower plasma levels of IL-6 and TNF-α-R2. Contrary to previous reports, however, there was no association between fiber and hs-CRP among postmenopausal women. Future studies on the influence of diet on inflammation should include IL-6 and TNF-α-R2 and enroll participants from ethnic minorities. NIH Public Access

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Section: Discussionmentioning

confidence: 90%

Association between dietary fiber and markers of systemic inflammation in the Women's Health Initiative Observational Study

et al. 2008

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“…Because adipose tissue produces , it is possible that circulating markers of inflammation mediate the effect of fat on insulin sensitivity. We have reported that CRP is associated with increased visceral fat and decreased glucose disposal in postmenopausal women (17). Hormone therapy increases CRP (20)(21)(22); however, it is unknown if the effect of HRT on glucose disposal is associated with circulating markers of inflammation.…”

Section: Introductionmentioning

confidence: 94%

“…Postmenopausal women also have increased circulating markers of inflammation compared to premenopausal women (16)(17). Specifically, high sensitivity C-reactive protein (CRP) and interleukin 6 (IL-6) are associated with increased cardiovascular events in these women (16,18).…”

Section: Introductionmentioning

confidence: 99%

Insulin resistance with hormone replacement therapy: associations with markers of inflammation and adiposity

Cooper

Burger

Toth

et al. 2007

American Journal of Obstetrics and Gynecology

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Objective-To determine if insulin resistance associated with combination hormone replacement therapy (HRT) is mediated by changes in serum markers of inflammation or in serum adipocyte hormones.Study design-Forty-five postmenopausal women, aged 55 ± 7 years, were examined from a randomized, double-blind placebo-controlled trial evaluating the effect of HRT on insulin-stimulated glucose disposal and body composition. Volunteers were randomized to conjugated estrogens 0.625 mg plus medroxyprogesterone acetate 2.5 mg vs. placebo for 1 year. At baseline and at 1 year, body composition was assessed by dual photon x-ray absorptiometry scans (DEXA); body fat distribution was measured by CT scans at the L4/L5 vertebral disc space; insulin sensitivity was measured by euglycemic hyperinsulinemic clamp; interleukin-6 (IL-6), leptin and adiponectin were measured by ELISA; and c-reactive protein (CRP) was measured by RIA.Results-HRT increased CRP by 121% compared to a 32% increase with placebo (p=0.03); HRT decreased glucose disposal by 17% compared to no change with placebo (p=0.04) as reported previously. HRT did not affect body composition, body fat distribution, IL-6, leptin, or adiponectin. The increase in CRP did not correlate with the decrease in glucose disposal in the HRT group (R=0.11, p=0.65).Conclusion-Treatment with HRT for one year increases CRP, but does not alter IL-6, adiponectin, or leptin. The change in CRP was not, however, related to the decrease in glucose disposal with HRT treatment.

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“…Some evidence suggests a possible role of insulin in stimulating acute-phase proteins (O'Riordain et al, 1995;Thompson et al, 1991) which have been directly related to intra-abdominal fat and inversely related to insulin-stimulated glucose disposal (Sites et al, 2002). HDL is considered a negative acute-phase protein (Malle et al, 1993) and has been found to be negatively associated to C-reactive protein (CRP) and acute and Glycemic index in chronic disease LS Augustin et al chronic inflammatory states (Bausserman et al, 1988;Rossner, 1978;Hardardottir et al, 1994).…”

Section: The Glycemic Index In Coronary Heart Diseasementioning

confidence: 99%

Glycemic index in chronic disease: a review

et al. 2002

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Aim: The intent of this review is to critically analyze the scientific evidence on the role of the glycemic index in chronic Western disease and to discuss the utility of the glycemic index in the prevention and management of these disease states. Background: The glycemic index ranks foods based on their postprandial blood glucose response. Hyperinsulinemia and insulin resistance, as well as their determinants (eg high energy intake, obesity, lack of physical activity) have been implicated in the etiology of diabetes, coronary heart disease and cancer. Recently, among dietary factors, carbohydrates have attracted much attention as a significant culprit, however, different types of carbohydrate produce varying glycemic and insulinemic responses. Low glycemic index foods, characterized by slowly absorbed carbohydrates, have been shown in some studies to produce beneficial effects on glucose control, hyperinsulinemia, insulin resistance, blood lipids and satiety. Method: Studies on the short and long-term metabolic effects of diets with different glycemic indices will be presented and discussed. The review will focus primarily on clinical and epidemiological data, and will briefly discuss in vitro and animal studies related to possible mechanisms by which the glycemic index may influence chronic disease.

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Menopause-related differences in inflammation markers and their relationship to body fat distribution and insulin-stimulated glucose disposal

Cited by 134 publications

References 29 publications

Association between dietary fiber and markers of systemic inflammation in the Women's Health Initiative Observational Study

Association between dietary fiber and markers of systemic inflammation in the Women's Health Initiative Observational Study

Insulin resistance with hormone replacement therapy: associations with markers of inflammation and adiposity

Glycemic index in chronic disease: a review

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