Menopause with cardiovascular disease and its risk factors among rural Chinese women in Beijing: A population-based study

He, Li; Tang, Xun; Li, N.; Wu, Yiqun; Wang, J.W.; Li, J.R.; Zhang, Z.X.; Dou, Hui-dong; Liu, J.J.; Yu, Liping; Xu, He; Zhang, J.G.; Hu, Yuanli

doi:10.1016/j.maturitas.2012.02.013

Cited by 59 publications

(72 citation statements)

References 29 publications

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“…Menopause is most likely one of the key players behind the substantial differences observed here between the male and female age-specific metabolic fingerprints. High TC, LDL, TG and apoB values have also previously been associated with menopause 14,15,29,31 . These lipid disturbances may be especially harmful in hyperglycaemic environment promoting oxidative injury 31,32 .…”

Section: Discussionmentioning

confidence: 95%

“…Earlier studies reported lower high-density lipoprotein cholesterol (HDL) concentration 6 combined with higher low-density lipoprotein cholesterol (LDL) 6 , triglycerides (TGs) and total cholesterol (TC) concentrations 13 among postmenopausal women compared with age-matched premenopausal controls. Later reports suggested LDL cholesterol and apolipoprotein-B (apoB) as age-independent menopausal biomarkers, whereas results on TC, HDL and TG have been controversial 14,15 . HDL tends to lose its protective effects against CVD after menopause, with an atherogenic shift to higher HDL particle number and smaller HDL particle size 16 .…”

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confidence: 99%

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A metabolic view on menopause and ageing

et al. 2014

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The ageing of the global population calls for a better understanding of age-related metabolic consequences. Here we report the effects of age, sex and menopause on serum metabolites in 26,065 individuals of Northern European ancestry. Age-specific metabolic fingerprints differ significantly by gender and, in females, a substantial atherogenic shift overlapping the time of menopausal transition is observed. In meta-analysis of 10,083 women, menopause status associates with amino acids glutamine, tyrosine and isoleucine, along with serum cholesterol measures and atherogenic lipoproteins. Among 3,204 women aged 40-55 years, menopause status associates additionally with glycine and total, monounsaturated, and omega-7 and -9 fatty acids. Our findings suggest that, in addition to lipid alterations, menopause may contribute to future metabolic and cardiovascular risk via influencing aminoacid concentrations, adding to the growing evidence of the importance of amino acids in metabolic disease progression. These observations shed light on the metabolic consequences of ageing, gender and menopause at the population level.

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Section: Discussionmentioning

confidence: 95%

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confidence: 99%

A metabolic view on menopause and ageing

et al. 2014

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“…This may be caused by particularity of women. Elderly women show an increased risk of CVD attributed to aging, less physically active, emotional disorders, and estrogen deprivation at time of menopause 27, 28. Moreover, scores for very elderly people may be influenced by external variation, and the very old who survive the study period may represent a different population from those who have previously died 29.…”

Section: Discussionmentioning

confidence: 99%

Cognitive Impairment and Risk of All‐Cause and Cardiovascular Disease Mortality Over 20‐Year Follow‐up: Results From the BLSA

Tang

et al. 2018

JAHA

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BackgroundCognitive impairment may increase the risk of all‐cause and cardiovascular disease (CVD) mortality. This study examined the association between cognitive function and risk of all‐cause and CVD mortality among the elderly in Beijing, China.Methods and ResultsA total of 1996 participants aged ≥55 years at baseline were enrolled from the BLSA (Beijing Longitudinal Study of Aging). Cognitive function was assessed using the Mini‐Mental State Examination (MMSE), and participants were categorized as: <18, 18 to 23, 24 to 27, and 28 to 30. Cox proportional hazard models were used to estimate the association. Hazard ratio (HR) and 95% confidence interval (CI) were reported. During a 20‐year follow‐up, 1122 (56.21%) participants died, 478 (42.60%) of whom died of CVD. Compared with MMSE scores of 28 to 30, participants with MMSE scores of <18 were independently associated with all‐cause mortality (hazard ratio, 2.14; 95% confidence interval, 1.59–2.87; P<0.001) and CVD mortality (hazard ratio, 4.52; 95% confidence interval, 2.80–7.30, P<0.001). Each 5‐point decrease in MMSE score was associated with a 34% increased risk of all‐cause mortality and a 56% increased risk of CVD mortality. This relationship remained statistically significant after using the competing risk model to consider non‐CVD death as a competing risk event.ConclusionCognitive impairment measured by MMSE score was associated with elevated risk of all‐cause and CVD mortality among the elderly in Beijing, China.

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“…These findings clearly indicate that the fluxes in the production of sex hormones after menopause might be accompanied with the risk of diabetes [35]. Though, the association between menopause and type 2 diabetes has been established [36][37][38][39][40], conclusion about whether the menopause by themselves influence the pathology of type 2 diabetes independently of aging remains controversial. In 2005, the crosssectional study conducted by Donato et al among the Italian women, reported a positive correlation between the menopausal state and diabetes independently of age [41].…”

Section: Postmenopausal Insulin Resistancementioning

confidence: 92%

Soy Isoflavones (from Glycine max) in Menopause Health and Diseases

Sankar¹,

Bobby²,

Mirza³

2017

Biochem Physiol

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As per the third consensus meeting of Indian Menopause Society reports, the number of postmenopausal women in India is approximately 43 million and it is projected to be 103 million by 2026. While the average age for menopause in India is 47.5 years, there is an alarming increase of premature menopause among the Indian women has been reported recently. It has been observed that, nearly four per cent women of age group of 29-34 years attain menopause and its incidence increases to eight per cent in women of age group between 35 and 39 years. The reason for this early menopause is still unclear, but it is a major public health problem because of its influence on the development of components of metabolic syndrome. Despite HRT improves postmenopausal complications, the prolonged use of HRT was not recommended now due to its influence on the development of certain types of cancers; endometrial cancer and breast cancer in addition to its negative impact on cardiovascular diseases. Hence, understanding the cellular and molecular mechanisms which amenable for the pathogenesis of postmenopausal complications may open new clinical therapeutic targets for the management of these complications. Soy isoflavones, a natural phytoestrogen, which shares the structural and functional homogeneity with estrogen. Several studies have reported that soy isoflavones have beneficial effects against ovariectomy (surgical menopause) as well as diet induced metabolic complications in animal models; however, its efficacy in terms of improving metabolic complications associated with postmenopausal state is largely unclear.

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Menopause with cardiovascular disease and its risk factors among rural Chinese women in Beijing: A population-based study

Cited by 59 publications

References 29 publications

A metabolic view on menopause and ageing

A metabolic view on menopause and ageing

Cognitive Impairment and Risk of All‐Cause and Cardiovascular Disease Mortality Over 20‐Year Follow‐up: Results From the BLSA

Soy Isoflavones (from Glycine max) in Menopause Health and Diseases

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