Menorrhagia Impact Questionnaire: assessing the influence of heavy menstrual bleeding on quality of life

Bushnell, Donald M.; Martin, Mona L.; Moore, Keith A.; Richter, Holly E.; Rubin, Arkady; Patrick, Donald L.

doi:10.1185/03007995.2010.532200

Cited by 51 publications

(45 citation statements)

References 24 publications

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“…The present interim analysis of the study reports 24-month postoperative qualitative outcomes in terms of participants' responses to questionnaires (UFS-QOL, EQ-5D, overall treatment effect survey, and the MIQ [16][17][18][19]), re-interventions for fibroid symptoms, and pregnancy outcomes. According to the study method, the participants will be followed for a total of 5 years.…”

Section: Methodsmentioning

confidence: 99%

“…Similarly, the EuroQoL (EQ-5D) health-state survey is a validated, multi-attribute health-state classification system that indicates the burden of illness in terms of mobility, self-care, ability to complete normal activities, pain/discomfort, and anxiety or depression [18]. The menstrual impact questionnaire (MIQ) is especially useful for gauging the burden of menstrual bleeding a patient is experiencing at the time of questioning [19].…”

Section: Introductionmentioning

confidence: 99%

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Interim analysis of a randomized controlled trial comparing laparoscopic radiofrequency volumetric thermal ablation of uterine fibroids with laparoscopic myomectomy

Krämer

Hahn

Taran

et al. 2015

Intl J Gynecology & Obste

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Objective: To compare 24-month patient-reported outcomes following laparoscopic radiofrequency volumetric thermal ablation (RFVTA) and laparoscopic myomectomy in patients with uterine fibroids. Method: An interim analysis of 24-month follow-up data from a randomized controlled trial was performed at Tübingen University Women's Hospital between November 1, 2012 and May 30, 2015. Premenopausal patients, at least 18 years of age, who were menstruating, were randomly assigned to be treated for symptomatic uterine fibroids with either RFVTA or laparoscopic myomectomy. The outcomes included in the present per-protocol analysis were patients' responses to validated questionnaires and long-term safety. Results: The study enrolled 51 patients; 21 and 22 patients in the RFVTA and laparoscopic myomectomy groups, respectively, completed 24 months of follow-up. Improvements in the severity of symptoms from baseline were reported by participants in both the RFVTA (P b 0.001) and laparoscopic myomectomy groups (P = 0.001). A significant improvement in health-related quality of life was observed in the laparoscopic myomectomy group (P = 0.040); a non-significant improvement was recorded in the RFVTA group (P = 0.083). A trocar-site hematoma occurred in one patient in the laparoscopic myomectomy group. Further surgical interventions were recorded in three patients in the RFVTA group but these were unrelated to fibroid symptoms. Conclusions: These 24-month data suggest equivalence in safety and patient-reported efficacy of RFVTA and laparoscopic myomectomy. ClinicalTrials.gov: NCT01750008

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Interim analysis of a randomized controlled trial comparing laparoscopic radiofrequency volumetric thermal ablation of uterine fibroids with laparoscopic myomectomy

Krämer

Hahn

Taran

et al. 2015

Intl J Gynecology & Obste

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show abstract

“…The ROC analyses provide a means to identify MBL values that balance sensitivity (i.e., true positive condition existence) and specificity (i.e., true negative condition existence) for the prediction of a patient-perceived meaningful improvement 4 . The objective measure of HMB was determined by quantifying MBL and the subjective measure of a meaningful or important response was assessed using a validated patient-reported outcome measure, the Menorrhagia Impact Questionnaire (MIQ) 5 . As the degree of MBL reduction that is considered meaningful may depend on baseline HMB severity, stratification by baseline MBL was also evaluated.…”

Section: Introductionmentioning

confidence: 99%

Estimating a meaningful reduction in menstrual blood loss for women with heavy menstrual bleeding

Lukes

Muse

Richter

et al. 2010

Current Medical Research and Opinion

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“…Development of patient‐reported outcome measures for HMB is an active area of interest and investigation. Although questionnaires have been developed and used, they have not been used consistently across studies or become the ‘standard’ by which menstrual bleeding‐related quality of life is measured . The theoretical model we used as the foundation for our questionnaire was based on patient input and incorporates social embarrassment, fear of social embarrassment, and behaviour changes to avoid embarrassment.…”

Section: Discussionmentioning

confidence: 99%

The menstrual bleeding questionnaire: development and validation of a comprehensive patient-reported outcome instrument for heavy menstrual bleeding

Matteson

Scott

Raker

et al. 2015

BJOG: Int J Obstet Gy

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Objective To develop and validate a patient-reported outcome measure for women with heavy menstrual bleeding (HMB) Study Design Prospective cohort and cross-sectional studies Setting Outpatient women’s health facility Population or Sample Women ages 18 and 55 years with and without self-reported HMB Methods Utilising data from patients and clinicians, we developed a patient-reported outcome measure for HMB; the Menstrual Bleeding Questionnaire (MBQ). Participants in the validation studies completed demographic and general health questionnaires and either (1) bleeding and quality of life data collected daily on handheld computers and the MBQ after one month or (2) the MBQ at enrollment only. A subset of women also completed the SF-36 generic quality of life questionnaire. We performed psychometric analyses of the MBQ to assess its internal consistency as well as its content and concurrent validity and ability to discriminate between women with and without HMB. Main Outcome Measures Psychometric properties of the questionnaire Results Overall, 182 women participated in the MBQ validation studies. We found that the MBQ domains were internally consistent (Cronbach’s alpha =0.87–0.94). There was excellent correlation between daily bleeding-related symptom data and the MBQ completed at one month (rho >0.7 for all domains). We found low to moderate correlation between the MBQ scores and SF-36 scores (rho= −0.15 to −0.45). The MBQ clearly discriminated between women with and without HMB (mean MBQ score=10.6 versus 30.8, p<0.0001). Conclusions The MBQ is a valid patient-reported outcome measure for HMB that has the potential to improve the evaluation of women with self-reported HMB in research and clinical practice.

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Menorrhagia Impact Questionnaire: assessing the influence of heavy menstrual bleeding on quality of life

Abstract: NCT00113568 and NCT00386308 (ClinicalTrials.gov ID).

Cited by 51 publications

References 24 publications

Interim analysis of a randomized controlled trial comparing laparoscopic radiofrequency volumetric thermal ablation of uterine fibroids with laparoscopic myomectomy

Interim analysis of a randomized controlled trial comparing laparoscopic radiofrequency volumetric thermal ablation of uterine fibroids with laparoscopic myomectomy

Estimating a meaningful reduction in menstrual blood loss for women with heavy menstrual bleeding

The menstrual bleeding questionnaire: development and validation of a comprehensive patient-reported outcome instrument for heavy menstrual bleeding

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