Menorrhagia in Adolescents with Inherited Bleeding Disorders

Chi, Claudia; Pollard, Debra; Tuddenham, Edward G. D.; Kadir, Rezan A.

doi:10.1016/j.jpag.2009.11.008

Cited by 98 publications

(129 citation statements)

References 27 publications

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“…This effect has been reported in other studies, i.e. heavy menstrual blood loss adversely affects quality of life, especially the assessment of general health and vitality, due to reduced energy and increased pain [20,24].…”

Section: Bleeding and Painsupporting

confidence: 66%

Health-related quality of life in young women starting hormonal contraception: a pilot study

Kristjánsdóttir

Sundelin

Naessén

2018

The European Journal of Contraception & Reproductive Health

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Objectives: Our purpose was to study whether there is a difference in self-rated health-related quality of life (HRQOL) and changes in HRQOL perception after 3 months of hormonal contraceptive use in adolescents. Seasonal variations in symptoms of depression were also studied. Methods: A test group (T1) (n ¼ 193) and a selected control group (n ¼ 238) of women aged 14-20 years who were visiting a young person's clinic completed the 36-item short-form health survey (SF-36) and answered additional questions on menstrual history and pattern, need for menstrual pain relief medication, and other regular medication. The test group was reassessed after 3 months of hormonal contraception (T2). Seasonal variations in reported SF-36 scores were studied for the whole group. Results: The selected control group and test group at T1 were similar with regard to age at menarche and menstrual pattern. The duration of bleeding and use of painkillers were significantly reduced and the impact on everyday life was significantly improved after 3 months of hormonal contraception (p ¼ .000, two-tailed). No changes in HRQOL or symptoms of possible depression were found after 3 months of hormonal contraception. The highest prevalence odds ratio for possible depression (SF-36 mental health scale score 48), adjusted for group, season and age, for spring vs winter, was 2.15 (95% confidence interval 0.95, 4.85). Conclusions: After 3 months of hormonal contraception both the number of days of menstrual bleeding and the use of medication to relieve menstrual pain were reduced, but there were no significant changes in self-rated HRQOL perception. Seasonal effects on HRQOL were reported. ARTICLE HISTORY

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Section: Bleeding and Painsupporting

confidence: 66%

Health-related quality of life in young women starting hormonal contraception: a pilot study

Kristjánsdóttir

Sundelin

Naessén

2018

The European Journal of Contraception & Reproductive Health

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“…8 But coagulopathies are not considered as etiology of menorrhagia by gynecologists and unintentional surgical intervention is done without getting the patients investigated for coagulopathies. 9 Our study emphasizes the importance of careful history taking since certain factors significantly predict menorrhagia viz., menorrhagia since menarche, presence of other bleeding symptoms like bruising, epistaxis, gum bleeding and history of postoperative bleeding and postpartum hemorrhage.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Causes of Menorrhagia in Patients With Normal Pelvic Pathology

C¹,

E²

2015

jemds

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OBJECTIVE: To find the incidence of systemic causes of menorrhagia with special emphasis on careful history taking, clinical examination and inclusion of simple blood tests to diagnose hemostatic disorders. METHOD: Thirty two women with menorrhagia of 15-45 years age, without any pelvic cause and treated from 1st January, 2011 to 31st December, 2011 were recruited for this study. After a detailed history and general examination all patients were subjected to blood tests for complete blood count, bleeding time, prothrombin time, activated partial thromboplastin time (aPTT) and serum T3, T4, TSH levels. Special tests were reserved, wherever applicable, to diagnose the cause of menorrhagia. Results were analyzed statistically by 2 x 2 chi square test. RESULTS: Hypothyroidism (25%) and inherited coagulopathy (18%) were the two most common nonpelvic causes of menorrhagia. Menorrhagia from menarche (P<0.001), bleeding from other sites (P=0.007), history of previous operative bleeding (P<0.001), and history of postpartum bleeding (P<0.001) were statistically significant in patients with underlying hemostatic disorders. CONCLUSION(S):A detailed history, clinical examination and simple blood tests can detect systemic causes of menorrhagia.

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“…Hormonal contraception may decrease menorrhagia in women with platelet disorders. 51 Proper dental hygiene from infancy is important to preempt invasive dental procedures later in life. Education of the risks of bleeding and its impact on elective surgeries such as wisdom teeth extraction is often needed for parents and medical caregivers.…”

Section: Local Measuresmentioning

confidence: 99%

What To Do When You Suspect an Inherited Platelet Disorder

Lambert

2011

Hematology

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Inherited platelet disorders (IPDs) comprise a heterogenous group of diseases that include defects in platelet function and disordered megakaryopoiesis. Some IPDs overlap as both defects in function and thrombopoiesis, resulting in both altered aggregation and/or secretion and thrombocytopenia. This review examines the key features of the presentation of IPDs in children and adults and presents a diagnostic algorithm for the evaluation of these patients. In addition, recent advances in our understanding of the pathophysiology of platelet disorders are addressed, with attention given to some of the novel genetic associations. Finally, treatment options and future therapies are briefly discussed.

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Menorrhagia in Adolescents with Inherited Bleeding Disorders

Cited by 98 publications

References 27 publications

Health-related quality of life in young women starting hormonal contraception: a pilot study

Health-related quality of life in young women starting hormonal contraception: a pilot study

Analysis of Causes of Menorrhagia in Patients With Normal Pelvic Pathology

What To Do When You Suspect an Inherited Platelet Disorder

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