The menstrual cycle has attracted the interest of many researchers for many years. It is analyzed from many angles, including its impact on mental health. Hormonal changes over the course of the cycle have a very strong impact on the emotions, needs, or pain experienced. Estrogen, secreted shortly before ovulation, influences increased confidence and feelings of attractiveness, which can lead to new relationships. In contrast, progesterone, secreted during the luteal phase, promotes the strengthening of stable relationships, and a large proportion of women may experience premenstrual syndrome (PMS) during this time. This publication discusses studies from recent years that have assessed the variability of women’s needs and emerging symptoms during different phases of the cycle. It also summarizes any strategies and practical tips needed to work with women considering their cyclical variability.