Menstrual bleeding patterns and prevalence of bleeding disorders in a multidisciplinary adolescent haematology clinic

Abstract

Summary Heavy menstrual bleeding (HMB) is a frequent complaint in adolescence. Although HMB is often caused by immaturity of the hypothalamic‐pituitary‐ovarian axis, bleeding disorders are another common yet often unidentified cause. The aim of this study was to examine the bleeding patterns and prevalence of inherited bleeding disorders among females referred for HMB to a multidisciplinary adolescent haematology clinic. We retrospectively reviewed the first 105 patients (ages 8–18 years) referred to this specialty clinic from February 2009 to December 2011. Using menstrual bleeding questionnaires and medical records, data were extracted regarding demographics, bleeding patterns, frequency and types of bleeding disorders identified, and prescribed interventions. Sixty‐two per cent of patients were diagnosed with a bleeding disorder, including platelet storage pool deficiency (36%), von Willebrand's disease (9%), other platelet function defect (8%), Ehlers‐Danlos syndrome (7%) and combined bleeding disorders (2%). Comparison of the bleeding profiles for females with and without a bleeding disorder revealed only three factors that were significantly different, including the reported regularity of patients' periods (P = 0.02), description of period flow (P = 0.04) and number of days of each period that the bleeding was described as ‘heavy’ (P = 0.007). Bleeding disorders are prevalent in adolescent females presenting to a specialty clinic. Specifically, a relatively high proportion of adolescents were diagnosed with platelet storage pool deficiency. In our small population, menstrual bleeding profiles, as examined by a standardized questionnaire, could not identify females with an underlying bleeding disorder, demonstrating the important role of haemostasis testing in the evaluation of adolescents with HMB.

Study of Adolescent Abnormal Uterine Bleeding (Aub) and Its Outcome - In Tertiary Centre K.I.M.S. Karad

“…It is a significant cause of abnormal uterine bleeding with prevalence ranging from 3 to 44% in various studies. 23,24,25 Coagulopathy accounted for 2.42% cases of AUB in our study. VWD and platelet dysfunction are the commonest hemostatic abnormalities which are seen in adolescents with AUB 26,27,28 However we did not encounter any such case.…”

Gynecologic Approach to Abnormal Uterine Bleeding in Adolescents

“…Anormal uterin kanamaya yol açan en sık hematolojik hastalık von Willebrand hastalığıdır. Her ne kadar genel popülasyonda görülme sıklığı düşük olsa da (%1), anormal uterin kanaması olan adolesanlarda prevalans % 3-36 arasında bildirilmektedir (8,9) . Genel koagülasyon bozuklukları da ikinci en sık nedeni oluşturmaktadır.…”

Sodobni pristop za diagnosticiranje prirojenih motenj delovanja trombocitov

“…Von Willebrandova bolezen (VWB), ki je v populaciji zastopana v približno 1 %, je vzrok menoragiji v 9-20 % (5-7). Za nastanek menoragije pa je v enakem ali še večjem odstotku, vzrok PMDT (6,(8)(9)(10)(11).…”