Menstrual Cycle in Women Addicted to Alcohol During the First Week Following Drinking Cessation--Changes of Sex Hormones Levels in Relation to Selected Clinical Features

Augustyńska, Beata; Ziółkowski, Marcin; Odrowąż-Sypniewska, Grażyna; Kiełpiński, A.; Gruszka, M.; Kosmowski, Wojciech

doi:10.1093/alcalc/agl094

Cited by 17 publications

(11 citation statements)

References 12 publications

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“…This link is rather complex as dysfunction caused by alcohol drinking women seems to vary by phase (follicular, ovulation, or luteal phases), whether pre- or post-menopausal, AD or not, drinking status (active, withdrawal, or abstinence) and family history of alcoholism. Moreover, women dependent on alcohol often experience menstrual cycle irregularities such as amenorrhea and infertility (Augustyńska et al 2007). …”

Section: Reproductive Hormonesmentioning

confidence: 99%

The Relationship of Appetitive, Reproductive and Posterior Pituitary Hormones to Alcoholism and Craving in Humans

et al. 2012

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Section: Reproductive Hormonesmentioning

confidence: 99%

The Relationship of Appetitive, Reproductive and Posterior Pituitary Hormones to Alcoholism and Craving in Humans

et al. 2012

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“…These changes included altered spermatogenesis and sperm motility, testicular atrophy and accessory gland morphology, reduced cauda epididymal sperm content, impaired sperm maturation, hypogonadism, feminization, alterations in reproductive hormones, infertility, delayed sexual maturation, and reduced libido (Anderson et al 1989;Van Thiel 1990, Kim et al 2003. In women and rodents, ethanol intake leads to altered ovulation (Cebral et al 1998a;Augustyńska et al 2007) and induces high incidence of chromosomic anomalies in exposed oocytes (Kaufman 1997). The mutagenic effect of ethanol on germ cells is controversial and this effect is probably associated with impaired gamete morphology.…”

Section: Introductionmentioning

confidence: 99%

Male and female reproductive toxicity induced by sub-chronic ethanol exposure in CF-1 mice

2011

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Since genetic damage induced by ethanol exposure is controversial and incomplete and because germ and somatic cells constitute bioindicators for monitoring reproductive toxicity and genotoxic actions of ethanol consumption, the purpose of the present investigation was to evaluate morphological sperm, oocyte alterations and parental genotoxic effects after sub-chronic ethanol intake in the CF-1 outbred mouse strain. Ethanol 10% was administered to CF-1 adult male (treated males, TM) and female (treated females, TF) mice for 27 days, whereas water was given to controls from both sexes too (CM and CF). Post-treatment micronucleus frequency (MN-PCE/1,000/mouse) and gamete morphology were evaluated. To test whether change of female reproductive status results in maternal genotoxicity, CF-1 females received ethanol 10% (exposed group, periconceptionally treated females (PTF)) or water (control group, pregnant control females (PCF)) in drinking water for 17 days previous and up to 10 days of gestation. TM had a high percentage of abnormal spermatozoa vs CM (p < 0.001) and elevated parthenogenetic activated oocyte frequency appeared in TF vs CF (p < 0.001). Sub-chronic ethanol ingestion induced increased MN frequency in TM and TF (p < 0.01). In PTF, where blood alcohol concentrations were between 19-28 mg/dl, very significantly increased MN frequency was found vs PCF (p < 0.01), whereas MN values were similar to TF. These results show that sub-chronic alcohol ingestion in CF-1 mice produces sperm head dysmorphogenesis and oocyte nuclear anomalies, suggesting that morphological abnormalities in germ cells are probably related to parental genotoxicity after ethanol consumption.

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“…Four knots were located at 0, 3, 5, and fertile window during which menstrual cycle disturbances related to alcohol are most prominent. 36 If binge drinking during the fertile window was prevalent among the participants, we may have overestimated any association between regular alcohol consumption and fecundability. In addition, we lacked information on consumption of alcoholic beverages by male partners, which may be related both to the female partner's alcohol consumption and to decreased sperm quality.…”

Section: Discussionmentioning

confidence: 98%

Alcohol consumption and fecundability: prospective Danish cohort study

Mikkelsen

Riis

Wise

et al. 2016

BMJ

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Objective To investigate to what extent alcohol consumption affects female fecundability.Design Prospective cohort study.Setting Denmark, 1 June 2007 to 5 January 2016.Participants 6120 female Danish residents, aged 21-45 years, in a stable relationship with a male partner, who were trying to conceive and not receiving fertility treatment.Main outcome measures Alcohol consumption was self reported as beer (330 mL bottles), red or white wine (120 mL glasses), dessert wine (50 mL glasses), and spirits (20 mL) and categorized in standard servings per week (none, 1-3, 4-7, 8-13, and ≥14). Participants contributed menstrual cycles at risk until the report of pregnancy, start of fertility treatment, loss to follow-up, or end of observation (maximum 12 menstrual cycles). A proportional probability regression model was used to estimate fecundability ratios (cycle specific probability of conception among exposed women divided by that among unexposed women).Results 4210 (69%) participants achieved a pregnancy during follow-up. Median alcohol intake was 2.0 (interquartile range 0-3.5) servings per week. Compared with no alcohol consumption, the adjusted fecundability ratios for alcohol consumption of 1-3, 4-7, 8-13, and 14 or more servings per week were 0.97 (95% confidence interval 0.91 to 1.03), 1.01 (0.93 to 1.10), 1.01 (0.87 to 1.16) and 0.82 (0.60 to 1.12), respectively. Compared with no alcohol intake, the adjusted fecundability ratios for women who consumed only wine (≥3 servings), beer (≥3 servings), or spirits (≥2 servings) were 1.05 (0.91 to1.21), 0.92 (0.65 to 1.29), and 0.85 (0.61 to 1.17), respectively. The data did not distinguish between regular and binge drinking, which may be important if large amounts of alcohol are consumed during the fertile window.Conclusion Consumption of less than 14 servings of alcohol per week seemed to have no discernible effect on fertility. No appreciable difference in fecundability was observed by level of consumption of beer and wine.

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Menstrual Cycle in Women Addicted to Alcohol During the First Week Following Drinking Cessation--Changes of Sex Hormones Levels in Relation to Selected Clinical Features

Abstract: The menstrual cycle disturbances in alcoholic women are most prominent around the middle part of the cycle and age influences the pattern of hormonal changes.

Cited by 17 publications

References 12 publications

The Relationship of Appetitive, Reproductive and Posterior Pituitary Hormones to Alcoholism and Craving in Humans

The Relationship of Appetitive, Reproductive and Posterior Pituitary Hormones to Alcoholism and Craving in Humans

Male and female reproductive toxicity induced by sub-chronic ethanol exposure in CF-1 mice

Alcohol consumption and fecundability: prospective Danish cohort study

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