Menstrual cycle phase and responses to drugs of abuse in humans

Terner, Jolan M.; Wit, Harriet de

doi:10.1016/j.drugalcdep.2005.12.007

Cited by 172 publications

(166 citation statements)

References 77 publications

Supporting

Mentioning

154

Contrasting

Unclassified

Order By: Relevance

“…There is evidence to support the role of these variables in altering the behavioral effects of stimulants in females (e.g. Carroll et al, 2004;Lynch et al, 2002;Lynch, 2006;Terner and de Wit, 2006). Women have been shown to have an enhanced response (i.e.…”

Section: Discussionmentioning

confidence: 99%

Similar discriminative-stimulus effects of d-amphetamine in women and men

Vansickel

Lile

Stoops

et al. 2007

Pharmacology Biochemistry and Behavior

View full text Add to dashboard Cite

The results of controlled non-human animal and human laboratory studies are mixed regarding whether women and men respond differently to stimulant drugs. In order to assess potential gender differences in the effects of d-amphetamine, we conducted a retrospective-analysis of six studies conducted in our laboratory that used identical procedures and measures. Thirteen women and fourteen men learned to discriminate 15 mg oral d-amphetamine. After acquiring the discrimination (i.e., =80% correct responding on 4 consecutive sessions), the effects of a range of doses of damphetamine (0, 2.5, 5, 10, and 15 mg) alone and in combination with other drugs, were assessed. Only data from sessions in which d-amphetamine was administered alone were included in this analysis. d-Amphetamine functioned as a discriminative-stimulus and dose-dependently increased drug-appropriate responding. Women and men did not differ in their ability to discriminate damphetamine. Women and men differed on participant-ratings of high (women < men), nausea (women > men) and sluggish (women < men), women also experienced greater increases in diastolic pressure than men. Because the results of this study may have been confounded by the training procedures, future research should use other behavioral arrangements (e.g. drug self-administration) to determine if women and men respond differently to the effects of d-amphetamine.

show abstract

Section: Discussionmentioning

confidence: 99%

Similar discriminative-stimulus effects of d-amphetamine in women and men

Vansickel

Lile

Stoops

et al. 2007

Pharmacology Biochemistry and Behavior

View full text Add to dashboard Cite

show abstract

“…Females appear to be more sensitive to the positive effects of drugs than males, and the basis of the heightened susceptibility of females to abuse drugs may be attributable to the circulating ovarian hormones estrogen and progesterone Terner and de Wit, 2006). The female menstrual cycle is *To whom correspondence should be addressed: Jennifer L. Newman, Ph.D., Email: newma210@umn.educharacterized by fluctuations of steroid hormones across a 28-day cycle, beginning with menses on day 1 of the cycle.…”

Section: Introductionmentioning

confidence: 99%

Effects of menstrual cycle phase on the reinforcing effects of phencyclidine (PCP) in rhesus monkeys

Newman

Thorne

Batulis

et al. 2006

Pharmacology Biochemistry and Behavior

View full text Add to dashboard Cite

Substantive evidence indicates that there are sex differences in the reinforcing effects of drugs and gonadal steroid hormones, such as estrogen and progesterone, likely contribute to these differences. Among females, subjective effects of drugs differ as a function of menstrual cycle phase. The purpose of the present study was to compare oral self-administration of phencyclidine (PCP) in female rhesus monkeys (Macaca mulatta) across different phases of the menstrual cycle. Since the 28-day menstrual cycle of nonhuman primates is similar to that of humans, this model could provide important evidence supporting the implication that changes in the levels of gonadal hormones across menstrual phases can alter a drug's reinforcing effects. Oral self-administration of several concentrations of PCP (0.125, 0.25, and 0.5 mg/ml) was examined in three sexually mature female monkeys during 3-h experimental sessions. Menstrual cycle phase was determined by onset of menses, and verified by examining vaginal cytology. Overall, PCP self-administration was greater during the luteal phase, which is normally characterized by high levels of progesterone and moderate levels of estrogen, than the follicular phase, when levels of estrogen are increasing and progesterone levels are low. When examined within each phase, numbers of PCP deliveries were highest during the mid-luteal phase, compared to the early and mid-follicular phases. No differences in selfadministration were observed between early and mid-follicular phases, but a significant difference in PCP deliveries was found between mid-and late luteal phases at the lowest concentration of PCP tested. The results from this study suggest that PCP's reinforcing effects in female monkeys differ as a function of menstrual cycle phase.

show abstract

“…In women, results have revealed that the subjective effects of stimulants vary across the menstrual cycle (Terner and de Wit, 2006), with the greatest subjective effects observed when estrogen levels are high and relatively unopposed by progesterone (Justice and de Wit, 1999). Animal studies have directly manipulated estradiol with results showing that while removing estradiol either surgically (ie, ovariectomy, OVX) or pharmacologically (estrogen receptor blockade) reduces cocaine self-administration; estradiol replacement enhances it (Hu and Becker, 2008;Lynch et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Estradiol as a Mechanism for Sex Differences in the Development of an Addicted Phenotype following Extended Access Cocaine Self-Administration

Ramôa

Doyle

Naim

et al. 2013

Neuropsychopharmacol

View full text Add to dashboard Cite

Women progress more rapidly after initial cocaine use to addiction as compared with men. Similarly, female rats appear to require less cocaine exposure before developing an addicted phenotype with evidence implicating estradiol as a potential mechanism. The goals of this study were to determine whether there are sex differences in the magnitude of the addicted phenotype under optimized conditions that induce its development in both males and females and to determine the role of estradiol in this effect. Following acquisition, intact male and intact and ovariectomized (OVX) female rats with and without estradiol replacement were given access to cocaine (1.5 mg/kg per infusion) under either extended access (ExA; discrete trial procedure, 4 trials/h, 24 h/day, 10 days) or short access (ShA) conditions (20 infusions maximum/day, 3 days). Motivation to obtain cocaine (0.5 mg/kg/infusion), as assessed under a progressive-ratio schedule, was then examined following a 2-week abstinence period. Results showed that following ExA self-administration, both males and females developed an addicted phenotype, with 9 of 11 males and 8 of 10 females showing a greater than 15% increase in levels of motivation to obtain cocaine as compared with ShA controls. In contrast, within the OVX groups, responding was enhanced from control levels after ExA self-administration in estradiol-replaced rats only. These results suggest that while females may have an enhanced vulnerability to developing an addicted phenotype, they may be similar to males once addiction has developed. These results also suggest that estradiol is critically involved in the development of an addicted phenotype in females.

show abstract

Menstrual cycle phase and responses to drugs of abuse in humans

Cited by 172 publications

References 77 publications

Similar discriminative-stimulus effects of d-amphetamine in women and men

Similar discriminative-stimulus effects of d-amphetamine in women and men

Effects of menstrual cycle phase on the reinforcing effects of phencyclidine (PCP) in rhesus monkeys

Estradiol as a Mechanism for Sex Differences in the Development of an Addicted Phenotype following Extended Access Cocaine Self-Administration

Contact Info

Product

Resources

About