Menstrual Cycle Phase, Hormonal Contraception, and Alcohol Consumption in Premenopausal Females: A Systematic Review

Warren, Jasmine; Fallon, Victoria; Goodwin, Laura; Gage, Suzanne H.; Rose, Abigail K.

doi:10.3389/fgwh.2021.745263

Cited by 12 publications

(12 citation statements)

References 37 publications

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“…The study had several limitations. First, the analysis combined men and women in spite of known sex and hormone‐related differences in responses to alcohol (Flores‐Bonilla & Richardson, 2020 ; Warren et al, 2021 ). Possible sex differences will be addressed in a future study with a larger N. Second, in this subject sample, and under these conditions, alcohol produced relatively modest stimulating effects during the consumption period, and little impairment the morning after.…”

Section: Discussionmentioning

confidence: 99%

Effects of alcohol on sleep and nocturnal heart rate: Relationships to intoxication and morning‐after effects

Pabon

Greenlund

Carter

et al. 2022

Alcoholism Clin & Exp Res

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Background: Alcohol consumption produces feelings of well-being and stimulation, but also impairs psychomotor performance, disturbs cardiovascular function and sleep, and can disrupt next-day mood and behavior. A deeper understanding of how the acute effects of alcohol relate to its sleep and morning-after effects is needed to minimize harm resulting from its use. This study examined relationships between the effects of a high dose of alcohol on subjective and psychomotor measures, nocturnal heart rate, sleep quality, and morning-after mood and behavior. We hypothesized that alcohol would produce disturbances in cardiovascular and sleep regulation during the night, which would predict morning-after mood and behavioral performance.Methods: Thirty-one men and women participated in two overnight laboratory visits during which they consumed either alcohol (1.0 g/kg for men, 0.85 g/kg for women) or placebo (randomized, crossover design). They consumed the beverage from 8 to 9 pm, and remained in the laboratory overnight for polysomnographic sleep recording.Subjective and behavioral measures were obtained during consumption and at 7-8 am the morning after.Results: Alcohol increased both negative and positive arousal, urge to drink and sedation, and it impaired performance on behavioral tasks. During sleep, alcohol produced expected tachycardia and detriments in sleep quality including decreased total sleep time, sleep efficiency, and altered sleep architecture. Only modest effects on mood or performance were detected the following morning. The acute sedative-like effects of alcohol were related to increases in N2 sleep, but not to other disruptions in sleep or nocturnal heart rate, and neither sleep impairments nor nocturnal heart rate were related to mood or task performance the morning after. Conclusions:The effects of alcohol on sleep and nocturnal heart rate were not strongly related to either its acute or morning-after effects. These findings do not provide strong support for the idea that alcohol-induced sleep disruptions underlie morning-after effects.

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Section: Discussionmentioning

confidence: 99%

Effects of alcohol on sleep and nocturnal heart rate: Relationships to intoxication and morning‐after effects

Pabon

Greenlund

Carter

et al. 2022

Alcoholism Clin & Exp Res

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“…One potential reason that correlations between gonadal hormones and alcohol consumption are more often detected in males than females may also be that gonadal hormone levels vary over the menstrual cycle. However, current evidence that alcohol consumption is associated with the menstrual cycle is inconsistent [140]. This may be due in part to differences in how the menstrual cycle is measured and whether or not the use of hormone-base contraceptives were included in study designs/models [140,141].…”

Section: Discussionmentioning

confidence: 99%

“…However, current evidence that alcohol consumption is associated with the menstrual cycle is inconsistent [140]. This may be due in part to differences in how the menstrual cycle is measured and whether or not the use of hormone-base contraceptives were included in study designs/models [140,141].…”

Section: Discussionmentioning

confidence: 99%

Gonadal Sex and Sex-Chromosome Complement Interact to Affect Ethanol Consumption in Adolescent Four Core Genotypes Mice

Aarde

Bagley

Jentsch

2022

Preprint

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Background: Sex differences in ethanol consumption have been reported in both humans and laboratory rodents, but the independent/dependent contributions of genetic and hormonal sex‑biasing mechanisms to these phenotypes have not yet been fully explored. Methods: To examine the contributions of sex-chromosome complement (SCC) and gonadal sex (GS) to ethanol consumption, we studied adolescent (28-32 days old) four core genotypes (FCG) mice (C57BL/6J background; FCG model allows for independent assortment of GS and SCC) using a modified drinking-in-the-dark (DID) procedure. Mice were offered concurrent access to 20%, 10% and 0% ethanol (in water) in four daily 2-hour sessions. Consumption at the level of individual bouts was recorded. Results: Although all four genotype groups preferred the 20% ethanol over 10% and 0%, and showed similar consumption of the 10% and 0% solutions, the group rankings for consumption of the 20% ethanol solution were XX+testes > XY+testes > XY+ovaries > XX+ovaries. Thus, an interaction was observed between SCC and GS for which the simple effect of SCC was greatest in mice with ovaries (XY > XX) and the simple effect of GS was greatest in XX mice (testes > ovaries). Moreover, these effects varied in magnitude across and within drinking sessions. The behavioral microstructure of ethanol consumption (i.e., parameterization of within-session discriminable drinking bouts) support the validity of our 3-bottle modification of the DID procedure as a model of binge-like consumption as: (1) the consumption rate of the 20% ethanol solution was ~80 g EtOH/kg/h within a bout (~12 s/bout, ~3 bouts/session), (2) most of this ethanol consumption was completed in a single bout and (3) within-session ethanol consumption was greater earlier than later, indicating "front loading." Conclusions: These results indicate that SCC and GS interact on ethanol consumption in adolescent FCG mice on a C57BL/6J background to affect binge-like consumption from the very initiation of access and that these effects are dynamic as they varied both across and within sessions.

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“…Sex hormones also reciprocally interact with alcohol use ( 7 ). Some studies have observed elevated BACs and increased behavioral sensitivity to alcohol during mid-luteal and ovulatory phases, as compared with follicular phases ( 8 – 10 ) although there are mixed results with regard to any association between the menstrual cycle phase and alcohol consumption ( 11 ). In terms of patterns of alcohol consumption, research suggests that women are generally more likely to drink to regulate stress reactivity and negative affect [for review see Peltier et al ( 12 )], are more likely to relapse in response to stress, and also more likely to show a sensitized stress response during alcohol withdrawal relative to men ( 13 , 14 ).…”

Section: Introductionmentioning

confidence: 99%

Sex as a Potential Moderator for Baclofen Response in the Treatment of Alcohol Dependence

Morley

Louie

Hurzeler

et al. 2022

Front. Glob. Womens Health

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Background and AimsRecent studies indicate that sex may moderate the response to baclofen in the treatment of alcohol use disorder (AUD). We conducted a secondary analysis of a double-blind randomized controlled trial, Baclofen in the treatment of Alcohol Liver Disease (BacALD), to examine the moderating role of sex on treatment response to baclofen in reducing alcohol consumption.MethodsAlcohol-dependent patients (n = 104 including 74 men and 30 women) were treated for 12 weeks with baclofen (30 mg/day or 75 mg) or placebo. Predefined primary outcomes included time to lapse (any drinking) and relapse (≥ 5 drinks per day in men and ≥ 4drinks per day in women). Other outcomes included drinks per drinking day, the number of heavy drinking days, and percentage of days abstinent. We also examined the frequency of adverse events with an exploratory dose–response analysis.ResultsThere was a main effect of baclofen for days to first lapse for women (Log Rank: χ2 = 6.23, p = 0.01, d = 0.49) but not for men (Log Rank: χ2 = 2.48, p = 0.12, d = 0.22) and a marginal effect of baclofen for days to first relapse for women (Log Rank: χ2 = 3.15, p = 0.08, d = 0.27) but not for men (Log Rank: χ2 = 2.03, p = 0.16, d = 0.17). There were no significant effects of sex on the frequency of adverse events reported for the combined-dose or between-dose analysis (all p > 0.44).ConclusionBaclofen significantly delayed the time to lapse for women but not male participants. These findings provide some support for the hypothesis that sex may be a potential moderator of baclofen response in the treatment of AUD.Trial Registrationhttps://clinicaltrials.gov/ct2/show/NCT01711125, identifier: NCT01711125.

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Menstrual Cycle Phase, Hormonal Contraception, and Alcohol Consumption in Premenopausal Females: A Systematic Review

Cited by 12 publications

References 37 publications

Effects of alcohol on sleep and nocturnal heart rate: Relationships to intoxication and morning‐after effects

Effects of alcohol on sleep and nocturnal heart rate: Relationships to intoxication and morning‐after effects

Gonadal Sex and Sex-Chromosome Complement Interact to Affect Ethanol Consumption in Adolescent Four Core Genotypes Mice

Sex as a Potential Moderator for Baclofen Response in the Treatment of Alcohol Dependence

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