Menstrual cycle-related changes in plasma oxytocin are relevant to normal sexual function in healthy women

Salonia, Andrea; Nappi, Rossella E.; Pontillo, Marina; Daverio, Rita; Smeraldi, Antonella; Briganti, Alberto; Fabbri, Fabio; Zanni, Giuseppe; Rigatti, Patrìzio; Montorsi, Francesco

doi:10.1016/j.yhbeh.2004.10.002

Cited by 200 publications

(139 citation statements)

References 49 publications

Supporting

Mentioning

134

Contrasting

Unclassified

Order By: Relevance

“…Another possible explanation for the discrepancy is that the mothers recruited in this study were not confined to a specific phase of the menstrual cycle. Plasma OXT levels have been suggested to fluctuate throughout the menstrual cycle in both healthy women and non-human primates [45,46]. Conversely, there are also studies showing that plasma OXT concentrations are unchanged during the follicular and luteal phases of the menstrual cycle in women with mental disorders and normal women [47][48][49].…”

Section: Discussionmentioning

confidence: 99%

Plasma Oxytocin and Arginine-Vasopressin Levels in Children with Autism Spectrum Disorder in China: Associations with Symptoms

Zhang

Dai

et al. 2016

Neurosci. Bull.

View full text Add to dashboard Cite

Autism spectrum disorder (ASD) is defined by impairments of social interaction and the presence of obsessive behaviors. The ''twin'' nonapeptides oxytocin (OXT) and arginine-vasopressin (AVP) are known to play regulatory roles in social behaviors. However, the plasma levels and behavioral relevance of OXT and AVP in children with ASD have seldom been investigated. It is also unknown whether their mothers have abnormal plasma peptide levels. Here, using well-established methods of neuropeptide measurement and a relatively large sample size, we determined the plasma levels of the two neuropeptides in 85 normal children, 84 children with ASD, and 31 mothers from each group of children. As expected, children with ASD had lower plasma OXT levels than gender-matched controls (P = 0.028). No such difference was found for plasma AVP concentrations. Correlation analysis showed that ASD children with higher plasma OXT concentrations tended to have less impairment of verbal communication (Rho = -0.22, P = 0.076), while those with higher plasma AVP levels tended to have lower levels of repetitive use of objects (Rho = -0.231, P = 0.079). Unlike the findings in children, maternal plasma OXT levels showed no group difference. However, plasma AVP levels in the mothers of ASD children tended to be lower than in the mothers of normal children (P = 0.072). In conclusion, our results suggest that the OXT system is dysregulated in children with ASD, and that OXT and AVP levels in plasma seem to be associated with specific autistic symptoms. The plasma levels of OXT or AVP in mothers and their ASD children did not seem to change in the same direction.

show abstract

Section: Discussionmentioning

confidence: 99%

Plasma Oxytocin and Arginine-Vasopressin Levels in Children with Autism Spectrum Disorder in China: Associations with Symptoms

Zhang

Dai

et al. 2016

Neurosci. Bull.

View full text Add to dashboard Cite

show abstract

“…Other neuropeptide hormone concentrations that rise in the late follicular phase include prolactin (e.g., Subramanian et al, 1997) and oxytocin (Salonia et al, 2005). Incidentally, prolactin and oxytocin levels are also raised postpartum, when it is especially important that mothers bond with their child (e.g., Brunton and Russell, 2008).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Menstrual cycle phase affects discrimination of infant cuteness

Lobmaier

Probst

Perrett

et al. 2015

Hormones and Behavior

View full text Add to dashboard Cite

show abstract

“…In particular, no effort was made to control for phase of the menstrual cycle or sexual activity both of which have been reported to influence oxytocin (Carter et al, 2007;Salonia et al, 2005). While PHS were older than the other groups and initially had lower plasma osmolalities, inclusion of age in the model did not alter the findings and osmolality was normalized prior to sampling.…”

Section: Commentmentioning

confidence: 99%

Diminished plasma oxytocin in schizophrenic patients with neuroendocrine dysfunction and emotional deficits

Goldman

Marlow-O'Connor

Torres

et al. 2008

Schizophrenia Research

193

144

View full text Add to dashboard Cite

Polydipsic hyponatremic schizophrenic patients (PHS) exhibit enhanced plasma arginine vasopressin (pAVP) and hypothalamic pituitary adrenal (HPA) axis responses to stress that appear attributable to anterior hippocampal dysfunction. Neuroanatomic and electrophysiologic studies indicate oxytocin activity in PHS patients should also be affected. Furthermore, oxytocin normally diminishes HPA responses to stress and facilitates cognitive and behavioral functions impaired in schizophrenia, suggesting that diminished oxytocin activity could contribute to this subsets' neuropsychiatric disorder. In the present study, we measured plasma oxytocin levels at intervals before and after stress induction in six polydipsic hyponatremic (PHS), four polydipsic normonatremic (PNS), five nonpolydipsic normonatremic schizophrenic (NNS) patients and seven healthy controls. Most of these subjects also completed studies measuring their medial temporal lobe volumes, their hippocampal-mediated HPA feedback and their ability to discriminate different facial emotions (an oxytocin-sensitive measure which is markedly impaired in schizophrenia). Results demonstrated that 1) plasma oxytocin levels were lower (p = .006) in hyponatremic patients relative to the other three groups, whose levels were similar and did not change. Oxytocin levels across all subjects were 2) inversely correlated with anterior hippocampal (p = .004) (but not posterior hippocampal or amygdala volumes), and 3) directly correlated with the integrity of hippocampal-mediated HPA feedback (p = .039). Finally, 4) oxytocin levels predicted schizophrenic patients' ability to correctly identify facial emotions (p = .004). These preliminary data provide further evidence that neuroendocrine dysfunction in PHS reflects anterior hippocampal pathology and contributes to a characteristic neuropsychiatric syndrome.

show abstract

Menstrual cycle-related changes in plasma oxytocin are relevant to normal sexual function in healthy women

Cited by 200 publications

References 49 publications

Plasma Oxytocin and Arginine-Vasopressin Levels in Children with Autism Spectrum Disorder in China: Associations with Symptoms

Plasma Oxytocin and Arginine-Vasopressin Levels in Children with Autism Spectrum Disorder in China: Associations with Symptoms

Menstrual cycle phase affects discrimination of infant cuteness

Diminished plasma oxytocin in schizophrenic patients with neuroendocrine dysfunction and emotional deficits

Contact Info

Product

Resources

About