Menstrual-PGF2α, PGE2 and TXA2 in normal and dysmenorrheic women and their temporal relationship to dysmenorrhea

Powell, Andrea M.; Çhan, W. Y.; Alvin, Patrick; Litt, Iris F.

doi:10.1016/0090-6980(85)90208-4

Cited by 39 publications

(19 citation statements)

References 15 publications

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“…PGF 2α stimulates myometrial contractions, ischemia and sensitization of nerve endings (Filler et al, 1970). A previous study has demonstrated that PGF 2α in women with PD are higher than those in asymptomatic controls (Powell et al, 1985). In the present study, we demonstrated that GZFLC significantly reduced the generation of PGF 2α in uterus tissue induced by oxytocin in vivo.…”

Section: Discussionsupporting

confidence: 66%

Traditional Chinese medicine Guizhi Fuling capsule used for therapy of dysmenorrhea via attenuating uterus contraction

Sun

Liu

Zong

et al. 2016

Journal of Ethnopharmacology

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Section: Discussionsupporting

confidence: 66%

Traditional Chinese medicine Guizhi Fuling capsule used for therapy of dysmenorrhea via attenuating uterus contraction

Sun

Liu

Zong

et al. 2016

Journal of Ethnopharmacology

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“…While secondary dysmenorrhea can be a consequence of pathological conditions such as endometriosis or pelvic inflammatory disease, primary dysmenorrhea occurs in the absence of known pathological conditions [12] and is thought to be caused by prostaglandins synthesized before menstruation, leading to increased uterine contractility and pain [13–17]. Higher levels of leukotrienes in dysmenorrheic women also may exacerbate uterine contractions [16, 18, 19].…”

Section: Introductionmentioning

confidence: 99%

Menstrual pain and epithelial ovarian cancer risk

Babić

Cramer

Titus

et al. 2014

Cancer Causes Control

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Purpose Menstrual pain is associated with increased production of inflammatory molecules, such as prostaglandins. Inflammation is involved in pathogenesis of several cancers, including ovarian cancer. In this study we examined the association between menstrual pain and risk of ovarian cancer. Methods We conducted a case-control study with 2028 cases of epithelial ovarian cancer, and 2091 age and study center matched controls. Women were asked to report the severity of menstrual pain during their 20s and 30s, when not using oral contraceptives or breastfeeding. We used unconditional logistic regression to evaluate the association between menstrual pain and epithelial ovarian cancer risk overall, and polytomous logistic regression to evaluate whether the association differed across tumor subtypes. Results Risk of ovarian cancer was increased in women with moderate (OR=1.22, 95% CI: 1.05–1.42) and severe pain (OR = 1.34, 95% CI: 1.09–1.65) compared to women with no or mild pain during menstrual period. The association differed by histologic subtypes, with significant associations for severe pain with endometrioid (OR = 1.64, 95% CI: 1.15–2.34) and clear cell tumors (OR = 1.91, 95% CI: 1.11–3.28). Conclusions Our data suggest that moderate and severe pain during menstrual period is associated with increased risk of epithelial ovarian cancer. Due to high prevalence of menstrual pain in women of reproductive age this observation warrants further studies.

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“…In addition to stimulating muscle contractions, PGF 2a and PGE also result in ischemia and sensitization of nerve endings 3,4 . Furthermore, women who have severe dysmenorrhea have been shown to have higher levels of the prostaglandins in their menstrual fluid compared with women who experience normal menstruation 5 .…”

Section: Introductionmentioning

confidence: 99%

Etoricoxib in the treatment of primary dysmenorrhea in Chinese patients: a randomized controlled trial

Zhu

Zhang

et al. 2014

Current Medical Research and Opinion

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Menstrual-PGF2α, PGE2 and TXA2 in normal and dysmenorrheic women and their temporal relationship to dysmenorrhea

Cited by 39 publications

References 15 publications

Traditional Chinese medicine Guizhi Fuling capsule used for therapy of dysmenorrhea via attenuating uterus contraction

Traditional Chinese medicine Guizhi Fuling capsule used for therapy of dysmenorrhea via attenuating uterus contraction

Menstrual pain and epithelial ovarian cancer risk

Etoricoxib in the treatment of primary dysmenorrhea in Chinese patients: a randomized controlled trial

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