Mental disorders among adults with asthma: results from the World Mental Health Survey

Scott, Kate M.; Korff, Michael Von; Ormel, Johan; Zhang, Ming Yuan; Bruffærts, Ronny; Alonso, Jordi; Kessler, Ronald C.; Tachimori, Hisateru; Karam, Elie G.; Levinson, Daphna; Bromet, Evelyn J.; Posada‐Villa, José; Gasquet, Isabelle; Angermeyer, Matthias C.; Borges, Guilherme; Girolamo, Giovanni de; Herman, Allen; Haro, Josep María

doi:10.1016/j.genhosppsych.2006.12.006

Cited by 267 publications

(190 citation statements)

References 32 publications

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“…These findings are consistent with previous results showing links between childhood adversity and later asthma/respiratory diseases (Anda et al, 2008;Nomura & Chemtob, 2007; et al, 2008) and between earlier mental disorders and asthma in adulthood (Goodwin, Kroenke, Hoven, & Spitzer, 2003;Katon, Richardson, Lozano, & McCauley, 2004;Scott et al, 2007). But they also shed new light on possible factors that may contribute to this association by suggesting that depression and anxiety disorders and cigarette smoking may both contribute to the relationship between childhood abuse and adulthood respiratory disease.…”

Section: Discussionsupporting

confidence: 92%

Childhood Physical Abuse and Respiratory Disease in the Community: The Role of Mental Health and Cigarette Smoking

Goodwin

Wamboldt

2011

Nicotine & Tobacco Research

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Introduction: Previous studies have found an association between child abuse and respiratory disease in some populations, but the mechanisms remain unknown, and this association has not been examined in a representative community-based sample. The goal of this study was to examine the relationship between childhood physical abuse and the odds of respiratory disease and to investigate the role of depression, anxiety, and pack-years of smoking in this association.Methods: Data were drawn from the Midlife Development in the United States Survey (n = 3,032), a representative sample of adults aged 25-74 years. Multiple logistic regression analyses were used to determine the association between childhood abuse and current respiratory disease (past 12 months) and to examine whether pack-years of smoking, depression, and anxiety disorders mediated the relationship.Results: Individuals who often experienced childhood abuse had a significantly increased odds of respiratory disease (odds ratio [OR] = 1.87 [1.21, 2.90]). The association was attenuated, after adjusting for demographic characteristics and pack-years of smoking, and was no longer significant after adjusting for depression and anxiety disorders. Conclusions:These results are consistent with previous data suggesting a significant association between childhood abuse and respiratory disease and extend existing knowledge by providing initial evidence that demographic differences, depression and anxiety disorders, and lifetime cigarette smoking may mediate this observed relationship. Results require replication with longitudinal data in large community-based samples. Future studies that can explore potential biological mechanisms underlying the observed associations, such as immune factors, are needed next to better understand these relationships.

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Section: Discussionsupporting

confidence: 92%

Childhood Physical Abuse and Respiratory Disease in the Community: The Role of Mental Health and Cigarette Smoking

Goodwin

Wamboldt

2011

Nicotine & Tobacco Research

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“…Mental health problems can impact awareness of and adherence to the treatment of asthma; thus, depression is associated with poor asthma control, which can lead to an increase in asthma exacerbations (14)(15)(16). A shift in T helper type 2 immune response due to dysregulation of the hypothalamic-pituitary-adrenal axis in response to chronic stress has been cited as a likely biological mechanism by which depression and asthma are causally related (17)(18)(19).…”

Section: At a Glance Commentarymentioning

confidence: 99%

Depression and Risk of Incident Asthma in Adults. The CARDIA Study

Brunner

Schreiner

Sood

et al. 2014

Am J Respir Crit Care Med

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Rationale: Asthma is associated with depression, but the temporality of the association has not been established.Objectives: To examine the association between prevalent elevated depressive symptoms and incident asthma, and between prevalent asthma and incident elevated depressive symptoms in a cohort of young and middle-aged adults.Methods: We examined the longitudinal association between asthma and depressive symptoms bidirectionally in the Coronary Artery Risk Development in Young Adults (CARDIA) cohort. First, 3,614 participants, free of asthma, were classified by elevated depressive symptoms at the CARDIA Year-5 exam (n = 856 elevated vs. 2,758 not elevated; ages 23-35 yr) and followed for 20 years to incident asthma. Then, 3,016 participants, free of elevated depressive symptoms, were classified by self-reported current asthma status (n = 188 prevalent vs. 2,828 not prevalent) at the CARDIA Year-5 exam and followed for 20 years until onset of elevated depressive symptoms. Measurements and Main Results:The relative hazard of incident asthma among those with elevated depressive symptoms was 1.26 (95% confidence interval [CI] = 1.02-1.56) after adjustment for covariates. When depressive status was modeled as the total number of reports of elevated depressive symptoms before the onset of asthma, the adjusted hazard ratio was 1.15 (95% CI = 1.02-1.29). The hazard of incident elevated depressive symptoms for those with asthma was no different than the hazard in those without asthma (adjusted hazard ratio = 0.92; 95% CI = 0.70-1.20).Conclusions: This longitudinal observational study points to depression as a marker of risk for incident adult-onset asthma. On the other hand, prevalent asthma is not associated with incident adultonset depression.

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“…4 Patient-related factors associated with poor outcomes include co-morbidity with a variety of conditions including anxiety and depression, 5 and behavioural factors associated with psychological illnesses such as non-adherence and inadequate self-management skills. 6 Psychological conditions such as anxiety and depression have been reported in surveys to be common in people with asthma 7 and may be associated with poor control. 8 The aim of this paper is to explore this comorbidity in more detail.…”

Section: Introductionmentioning

confidence: 99%

Asthma and psychological dysfunction

Thomas

Bruton

Moffatt

et al. 2011

Primary Care Respiratory Journal

103

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Despite effective treatment, asthma outcomes remain suboptimal. Anxiety and depression occur more commonly in people with asthma than expected, and are associated with poor asthma outcomes. The direction of the relationship and the mechanisms underlying it are uncertain. Whether screening for and treating co-morbid anxiety and depression can improve asthma outcomes is unclear from the current evidence. Primary care clinicians treating asthma should be aware of the possibility of psychological dysfunction in asthmatics, particularly those with poor control. Further research is required to assess the importance of detecting and treating these conditions in community asthma care.

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Mental disorders among adults with asthma: results from the World Mental Health Survey

Cited by 267 publications

References 32 publications

Childhood Physical Abuse and Respiratory Disease in the Community: The Role of Mental Health and Cigarette Smoking

Childhood Physical Abuse and Respiratory Disease in the Community: The Role of Mental Health and Cigarette Smoking

Depression and Risk of Incident Asthma in Adults. The CARDIA Study

Asthma and psychological dysfunction

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