Mental disorders in systemic lupus erythematosus: a cohort study

Fernández, Heidi Ángela; Cevallos, Andrea; Jimbo, Ruth; Naranjo-Saltos, Fernando; Orcés, Diego Mera; Basantes, Efrain

doi:10.1007/s00296-019-04423-4

Cited by 26 publications

(25 citation statements)

References 32 publications

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“…Among the psychiatric manifestations of SLE, cognitive dysfunctions appear to be the most common manifestation. [ 9 ] In different cohorts, psychosis has been reported among 0%–11% NPSLE cases. [ 10 11 ] Study in Indian patients showed psychosis was the predominant symptom.…”

Section: Discussionmentioning

confidence: 99%

Acute psychosis as the presenting manifestation of lupus

Kumar

Thakur

et al. 2021

Journal of Family Medicine and Primary Care

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Neuropsychiatric manifestations like cognitive dysfunction, peripheral neuropathy, stroke headache, seizures in systemic lupus erythematosus (SLE) are quite common. However, psychosis as the sole presenting manifestation of SLE is rarely encountered clinically. If lupus is not kept as differential among patients with acute psychosis, delay in diagnosis and subsequent mismanagement are likely to happen. Here, we present a case of a young female presenting with acute psychosis as the predominant symptom and was further evaluated and diagnosed as a case of SLE. The patient was managed with immunosuppressive agents and carried an excellent outcome.

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Section: Discussionmentioning

confidence: 99%

Acute psychosis as the presenting manifestation of lupus

Kumar

Thakur

et al. 2021

Journal of Family Medicine and Primary Care

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“…Certain systemic and organ-specific autoimmune diseases, rheumatic mainly, can cause neuroinflammation. Fibromyalgia [ 4 ], destructive joint diseases [ 6 ], and systemic lupus erythematosus [ 3 ] are a few examples. Neurodegeneration studies suggest that peripheral infection might be related to onset and progression of age-related neurodegeneration [ 24 ].…”

Section: Neuroinflammatory Diseasesmentioning

confidence: 99%

“…Inflammation is emerging as a pivotal mechanism common to different neuropathological conditions [3][4][5][6][7][8][9][10].…”

Section: Neuroinflammatory Diseasesmentioning

confidence: 99%

Neuroinflammation: An Integrating Overview of Reactive-Neuroimmune Cell Interactions in Health and Disease

Kölliker-Frers

Udovin

Otero‐Losada

et al. 2021

Mediators of Inflammation

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The concept of central nervous system (CNS) inflammation has evolved over the last decades. Neuroinflammation is the response of reactive CNS components to altered homeostasis, regardless of the cause to be endogenous or exogenous. Neurological diseases, whether traumatic, neoplastic, ischemic, metabolic, toxic, infectious, autoimmune, developmental, or degenerative, involve direct and indirect immune-related neuroinflammation. Brain infiltrates of the innate and adaptive immune system cells appear in response to an infective or otherwise noxious agent and produce inflammatory mediators. Mediators of inflammation include local and recruited cells and signals. Processes derived from extrinsic and intrinsic CNS diseases also elicit the CNS inflammatory response. A deeper understanding of immune-related inflammation in health and disease is necessary to find potential therapeutic targets for preventing or reducing CNS damage. This review is aimed at discussing the innate and adaptive immune system functions and their roles in regulating brain cell responses in disease and homeostasis maintenance.

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“…Depression is frequently observed in patients with inflammatory diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). 48,49 Anti-inflammatory drugs for treatment of these diseases are sometimes effective for comorbid depression, that include nonsteroidal anti-inflammatory drugs (NSAIDs), cytokine inhibitors, N-acetylcysteine (NAC), antibiotics, and probiotics, which have also been proven to be effective in clinical trials for the treatment of depression per se. 50,51 Multiple studies have shown the anti-depressant effects of NSAIDs.…”

Section: Clinical Trials Targeting Inflammatory Molecules In Depressionmentioning

confidence: 99%

Inflamed brain: Targeting immune changes and inflammation for treatment of depression

Sakamoto

Zhu

Hasegawa

et al. 2021

Psychiatry Clin Neurosci

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Although there are a number of clinically effective treatments for depression, many patients exhibit treatment resistance. Recent clinical and preclinical studies reveal that peripheral and brain immune changes and inflammation are involved in the pathophysiology of depression. This 'Inflamed Brain' research provides critical clues for understanding of disease pathophysiology and many candidate molecules that are potentially useful for identifying novel drug targets for the treatment of depression. In this review, we will present clinical evidence on the role of inflammation in the pathophysiology of depression. We will also summarize current clinical trials which test drugs targeting inflammation for the treatment of patients with depression. Furthermore, we will briefly provide preclinical evidence demonstrating altered immune system function and inflammation in stress-induced animal models and will discuss the future potential of inflammationrelated drug targets. Collectively, inflammatory signatures identified in clinical and preclinical studies may allow us to stratify depressive patients based on biotypes, contributing to the development of novel mechanism-based interventions that target specific patient populations.

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Mental disorders in systemic lupus erythematosus: a cohort study

Cited by 26 publications

References 32 publications

Acute psychosis as the presenting manifestation of lupus

Acute psychosis as the presenting manifestation of lupus

Neuroinflammation: An Integrating Overview of Reactive-Neuroimmune Cell Interactions in Health and Disease

Inflamed brain: Targeting immune changes and inflammation for treatment of depression

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