Mental Disorders in Young Adults from Families with the Presenilin-1 Gene Mutation E280A in the Preclinical Stage of Alzheimer’s Disease

Villalba, Arvey Camilo; García, Jenny; Ramos, Cláudia; Cuastumal, Amanda; Aguillón, David; Aguirre–Acevedo, Daniel Camilo; Madrigal, Lucía; Lopera, Francisco

doi:10.3233/adr-190139

Cited by 2 publications

(1 citation statement)

References 46 publications

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“…Dr. Ramos serves as psychiatrist and researcher at the mental health program for patients with neurodegenerative diseases of the Neuroscience Group of University of Antioquia. She participated in a study assessing mental disorders in young adults from families with the presenilin-1 gene mutation e280a in the preclinical stage of AD ( Villalba et al, 2019 ). Also, she conducted a review of different genetic variants that cause AD or frontotemporal dementia in Latin America ( Ramos et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Latin American women in dementia research: outstanding contributions, barriers, and opportunities from Argentinian, Chilean, and Colombian colleagues

Fittipaldi

Báez

González‐Silva

et al. 2023

Front. Aging Neurosci.

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Women’s contributions to science have been consistently underrepresented throughout history. Despite many efforts and some progresses being made to reduce gender inequity in science, pursuing an academic career across disciplines, including Alzheimer’s disease (AD) and other dementias, remains challenging for women. Idiosyncratic difficulties of Latin American countries likely accentuate the gender gap. In this Perspective, we celebrate outstanding contributions from Argentinian, Chilean, and Colombian colleagues in dementia research and discuss barriers and opportunities identified by them. We aim to acknowledge Latin American women’s work and bring visibility to the challenges they face throughout their careers in order to inform potential solutions. Also, we highlight the need to perform a systematic assessment of the gender gap in the Latin American dementia community of researchers.

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Section: Introductionmentioning

confidence: 99%

Latin American women in dementia research: outstanding contributions, barriers, and opportunities from Argentinian, Chilean, and Colombian colleagues

Fittipaldi

Báez

González‐Silva

et al. 2023

Front. Aging Neurosci.

View full text Add to dashboard Cite

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Early Depressive Symptoms Predict Faster Dementia Progression in Autosomal-Dominant Alzheimer’s Disease

Acosta‐Baena

Gómez

Jaramillo-Elorza

et al. 2023

JAD

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Background: Depression is associated with Alzheimer’s disease (AD). Objective: To evaluate the association between depressive symptoms and age of onset of cognitive decline in autosomal dominant AD, and to determine possible factors associated to early depressive symptoms in this population. Methods: We conducted a retrospective study to identify depressive symptoms among 190 presenilin 1 (PSEN1) E280A mutation carriers, subjected to comprehensive clinical evaluations in up to a 20-year longitudinal follow-up. We controlled for the following potential confounders: APOE, sex, hypothyroidism, education, marital status, residence, tobacco, alcohol, and drug abuse. Results: PSEN1 E280A carriers with depressive symptoms before mild cognitive impairment (MCI) develop dementia faster than E280A carriers without depressive symptoms (Hazard Ratio, HR = 1.95; 95% CI, 1.15–3.31). Not having a stable partner accelerated the onset of MCI (HR = 1.60; 95 % CI, 1.03–2.47) and dementia (HR = 1.68; 95 % CI, 1.09–2.60). E280A carriers with controlled hypothyroidism had later age of onset of depressive symptoms (HR = 0.48; 95 % CI, 0.25–0.92), dementia (HR = 0.43; 95 % CI, 0.21–0.84), and death (HR = 0.35; 95 % CI, 0.13–0.95). APOE ɛ2 significantly affected AD progression in all stages. APOE polymorphisms were not associate to depressive symptoms. Women had a higher frequency and developed earlier depressive symptoms than men throughout the illness (HR = 1.63; 95 % CI, 1.14–2.32). Conclusion: Depressive symptoms accelerated progress and faster cognitive decline of autosomal dominant AD. Not having a stable partner and factors associated with early depressive symptoms (e.g., in females and individuals with untreated hypothyroidism), could impact prognosis, burden, and costs.

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Mental Disorders in Young Adults from Families with the Presenilin-1 Gene Mutation E280A in the Preclinical Stage of Alzheimer’s Disease

Cited by 2 publications

References 46 publications

Latin American women in dementia research: outstanding contributions, barriers, and opportunities from Argentinian, Chilean, and Colombian colleagues

Latin American women in dementia research: outstanding contributions, barriers, and opportunities from Argentinian, Chilean, and Colombian colleagues

Early Depressive Symptoms Predict Faster Dementia Progression in Autosomal-Dominant Alzheimer’s Disease

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