Unani Medicine (Also called Greco-Arab medicine) is an ancient system of medicine originated from Greece. It is more commonly practiced in the Indian Subcontinent and has an age-old concept and principles of drug management. This system is based on the Hippocratic theory of four humors viz. blood, phlegm, yellow bile and black bile, and the four qualities of states of living human body like hot, cold, moist and dry. For all individuals, mental, physical, and social health are vital strands of life that are closely interwoven, and deeply interdependent. As our understanding of this relationship grows, It becomes more apparent that mental health is crucial to the overall health of individuals, societies, and countries. Unfortunately, in most parts of the world, mental health and mental disorders are not given the same importance as physical health. Instead, they have been largely ignored and neglected. The world is suffering from an increasing burden of mental disorders and a widening treatment goal. The aim of this study is to assess the relationship between Mizaj and mental health. A cross sectional descriptive study to assess the Mizaj and mental health questionnaire with the help of Mizaj assessment proforma based on classical literature and oxford mental health questionnaire in 53(fifty three) apparently healthy individuals of different age of both gender, was carried out at A and U Tibbia college and hospital, Karol Bagh, New Delhi, India during period of June -October 2023 & this study was carried out in apparently healthy individuals. Analysis of data in the current study was done by calculating the Mean, Standard Deviation and One Way Analysis of Variance in SPSS 22.0 software for all the factors of Mizaj and Mental health score. The findings suggested that mental health score had significant association with the variability of Mizaj of the apparently healthy individuals.