Mental health and quality of life in different obesity phenotypes: a systematic review

Abstract

Objectives It has been suggested that obesity phenotypes are related to mental health problems and health-related quality of life (HRQoL). However, there is no certain consensus. This systematic review aimed to evaluate the association between different obesity phenotypes with common psychiatric symptoms and HRQoL. Methods Electronic databases i.e. PubMed, Scopus, EMBASE, and google scholar were searched until September 2021, to identify studies that investigated associations between the obesity phenotypes with psychiatric symptoms and/or mental and physical HRQoL. Two researchers independently checked titles and abstracts, evaluated full-text studies, extracted data, and appraised their quality using the Newcastle–Ottawa Scale. Results Eighteen studies, with a total of 3,929,203 participants, were included. Of the studies included in this systematic review, 10 articles evaluated the association between obesity phenotypes and psychiatric symptoms, while six papers investigated the association between HRQoL and obesity phenotypes, and two studies assessed both. As a whole, the findings of these studies suggest that obese individuals with a favorable metabolic profile have a slightly higher risk of mental health problems and poor quality of life, however, the risk becomes larger when obesity is combined with an adverse metabolic profile. So, metabolically healthy obesity may not be a completely benign condition in relation to mental disorders and poor quality of life. Conclusion According to published research, obesity is likely to increase the risk of mental health problems and poor quality of life when metabolic disturbances are present.

Effects of non‐nutritive sweetened beverages versus water after a 12‐week weight‐loss program: A randomized controlled trial

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Early Life Influences on the Development of Food Addiction in College Attending Young Adults

“…The worsening of mental health was another reason for the emergence of symptoms, which aligns with depression being a signi cant predictor in the quantitative results. Depression and anxiety are shown to be correlated with poorer diet quality [43,54] as well as overweight and obesity [55]. These ndings contribute to research on these topics, but also show that depression can cause the more severe outcome of food addiction, when combined with other in uences.…”

Real world evidence on the characteristics of regular and intermittent users of a very‐low calorie diet program and associations with measures of program success, health, and quality of life

“…While regular and intermittent users of the VLCD program were similar in several characteristics, distinct profiles emerged across user groups for percent weight loss (relative to starting weight) and several demographic, eating behavior and health factors. Regular users reported a higher per cent weight loss (relative to starting weight), program success, and score indicative of higher mental health and weight‐related QOL; however, weight‐related QOL and mental health across user groups were comparable to other populations with obesity, seeking or not seeking treatment 17–21 . Furthermore, intermittent users reported lower self‐efficacy and greater emotional and uncontrolled eating behaviors.…”