Mental Health Impact of Keratoconus: A Systematic Review

Durakovic, Emily; Kandel, Himal; Watson, Stephanie L.

doi:10.1097/ico.0000000000003263

Cited by 3 publications

(1 citation statement)

References 64 publications

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“…At the same time, there is a risk of vision loss during follow-up. This 'indefinite' state is also a major psychological burden for patients [6].…”

Section: Introductionmentioning

confidence: 99%

Longitudinal Analysis of Corneal Biomechanics of Suspect Keratoconus: A Prospective Case-Control Study

Huo,

Chen,

Xie

et al. 2024

Bioengineering

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Background: To evaluate the corneal biomechanics of stable keratoconus suspects (Stable-KCS) at 1-year follow-up and compare them with those of subclinical keratoconus (SKC). Methods: This prospective case-control study included the eyes of 144 patients. Biomechanical and tomographic parameters were recorded (Corvis ST and Pentacam). Patients without clinical signs of keratoconus in both eyes but suspicious tomography findings were included in the Stable-KCS group (n = 72). Longitudinal follow-up was used to evaluate Stable-KCS changes. Unilateral keratoconus contralateral eyes with suspicious tomography were included in the SKC group (n = 72). T-tests and non-parametric tests were used for comparison. Multivariate general linear models were used to adjust for confounding factors for further analysis. Receiver operating characteristic (ROC) curves were used to analyze the distinguishability. Results: The biomechanical and tomographic parameters of Stable-KCS showed no progression during the follow-up time (13.19 ± 2.41 months, p > 0.05). Fifteen biomechanical parameters and the Stress–Strain Index (SSI) differed between the two groups (p < 0.016). The A1 dArc length showed the strongest distinguishing ability (area under the ROC = 0.888) between Stable-KCS and SKC, with 90.28% sensitivity and 77.78% specificity at the cut-off value of −0.0175. Conclusions: The A1 dArc length could distinguish between Stable-KCS and SKC, indicating the need to focus on changes in the A1 dArc length for keratoconus suspects during the follow-up period. Although both have abnormalities on tomography, the corneal biomechanics and SSI of Stable-KCS were stronger than those of SKC, which may explain the lack of progression of Stable-KCS.

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“…At the same time, there is a risk of vision loss during follow-up. This 'indefinite' state is also a major psychological burden for patients [6].…”

Section: Introductionmentioning

confidence: 99%

Longitudinal Analysis of Corneal Biomechanics of Suspect Keratoconus: A Prospective Case-Control Study

Huo,

Chen,

Xie

et al. 2024

Bioengineering

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Save sight keratoconus registry study: Transepithelial versus epithelium-off corneal crosslinking

Borchert,

Kandel,

Gupta

et al. 2024

AJO International

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Depression among keratoconus patients: a systematic review and meta-analysis

Moshfeghinia,

Arman,

Sobhi

et al. 2024

Front. Public Health

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BackgroundKeratoconus (KC) is a chronic corneal disease that typically presents in early adulthood, and may potentially result in poor mental health in affected individuals. The evidence regarding the association of depression with KC is controversial. Hence, we investigated the association between depression and KC via a systematic review and meta-analysis.MethodsFive electronic medical databases (PubMed, Scopus, PsycINFO, Web of Science, and CINAHL Complete) were systematically queried for English-language records from their inception to January 8, 2024. We include observational studies that measured the risk of depression or compared depression scores in KC patients in comparison to healthy ones. The Newcastle–Ottawa Quality Assessment Scale was utilized to assess bias risk in the included studies. Random-effect modeling was applied for meta-analysis (STATA-17).ResultsOut of the 159 documents retrieved, seven articles were deemed relevant after screening. An analysis involving 83 KC patients and 3,186 controls indicated that KC participants had significantly higher depression scores [SMD: 0.71 [0.31, 1.11]; p < 0.01, I2: 52.7%]. However, a meta-analysis of four studies comparing depression rates in KC patients (n = 23,838) to control groups (n = 73,482) found no increased risk of depression among KC patients compared to controls [OR: 1.13 [0.66, 1.94]; p = 0.65, I2: 95.35%].ConclusionWhile KC patients exhibit significantly higher depression scores compared to controls, a meta-analysis indicates no increased overall risk of depression among KC patients. These findings highlight the complexity of the relationship between keratoconus and mental health, warranting further investigation.Systematic review registrationPROSPERO, identifier, CRD42024502247, available at: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024502247.

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Mental Health Impact of Keratoconus: A Systematic Review

Cited by 3 publications

References 64 publications

Longitudinal Analysis of Corneal Biomechanics of Suspect Keratoconus: A Prospective Case-Control Study

Longitudinal Analysis of Corneal Biomechanics of Suspect Keratoconus: A Prospective Case-Control Study

Save sight keratoconus registry study: Transepithelial versus epithelium-off corneal crosslinking

Depression among keratoconus patients: a systematic review and meta-analysis

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