Mental Health Status and Factors that Influence the Course of Graves’ Disease and Antithyroid Treatments

Chen, D. Y.; Schneider, Peter; Zhang, Xiaoshi; He, Zellmann; Jing, Jennie; Chen, T. H.

doi:10.1055/s-0032-1323807

Cited by 8 publications

(8 citation statements)

References 12 publications

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“…Adverse problems with the heart, bones, muscles, menstrual cycle and fertility can occur if hyperthyroidism is left untreated. Enhancing positive coping strategies and social support is important to improve mental health in Graves’ disease patients [ 3 ]. The quality of life of thyroid patients is substantially impaired over a wide range of aspects.…”

Section: Introductionmentioning

confidence: 99%

Is Hyperthyroidism a Possible Etiology of Early Onset Dementia?

Mathew

Jose

Elshaikh

et al. 2020

Cureus

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Dementia, a disabling syndrome of the elderly characterized by the decline in memory and cognition, is increasing in incidence and affects not only the individual but also their family and close ones. Hyperthyroidism can mimic many other diseases and untreated hyperthyroidism can lead to adverse problems of various systems including the heart, bones, muscles, menstrual cycle, and fertility. In this article, we have tried to evaluate the association between hyperthyroidism and dementia, as well as the impact of hyperthyroidism management in the treatment and prevention of dementia. Studies available in the PubMed database have been used, excluding animal studies and including studies of adults above the age of 50. The analysis of studies reveals that thyroid dysfunction can lead to cognitive impairment. It has not been able to prove that hyperthyroidism can lead to an earlier onset of dementia. But subclinical hyperthyroidism, thyroid-stimulating hormone (TSH) levels below the normal range, and high free thyroxine (T4) levels increase the risk of dementia among the elderly. The possible mechanisms involved in this association have also been discussed. Thus, we concluded that it is essential to detect and manage hyperthyroidism at an earlier stage since hyperthyroidism increases the risk of dementia. The possibility of using antithyroid treatment in euthyroid dementia is yet to be studied extensively.

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Section: Introductionmentioning

confidence: 99%

Is Hyperthyroidism a Possible Etiology of Early Onset Dementia?

Mathew

Jose

Elshaikh

et al. 2020

Cureus

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“…Furthermore, the aggravation of GD was also associated with mental disorders ( 33 , 34 ). Stress and adverse events may impact the immune system, resulting in an inflammatory response characterized by increased white blood cell counts and C-reactive protein (CRP) levels ( 35 , 36 ). However, the underlying mechanism still remains unclear.…”

Section: Discussionmentioning

confidence: 99%

The relationship between atherosclerotic disease and relapse during ATD treatment

Zhu

Zhang²,

Zhao³

et al. 2022

Front. Cardiovasc. Med.

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BackgroundClinical relapse is a potential risk for traditional antithyroid drug (ATD) treatment in hyperthyroid patients. Evidence suggests that atherosclerotic disease is closely associated with hyperthyroidism, while the relationship between atherosclerosis and relapse remains unclear.MethodsTwo hundred and twenty-five patients with GD who underwent ATD as their first treatment were studied; 88 and 137 patients were categorized as drug reduction relapse and drug reduction remission, respectively. Logistic regression was used to analyze risk factors of drug reduction relapse in patients with GD.ResultsDuring a median of 48 months followed up 88 patients who relapsed. According to multivariate analyses, atherosclerosis related diseases, FT4, goiter, and anxiety rating scores are independent risk factors for drug reduction. According to K-M survival analysis, patients with atherosclerosis related diseases, FT4 > 18.82 pmol/L, anxiety rating scores > 23, and gradation of goiter ≥ Grade II had a higher risk of relapse than those with lower levels. ROC analysis shown atherosclerosis related diseases significantly improved the predictive accuracy of relapse.ConclusionsAtherosclerotic disease is closely related to the relapse of hyperthyroidism, ATD treatment in hyperthyroid patients with atherosclerosis should be given more attention.

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“…The scale includes 48 common LEs categorized as work-related, family-related, or other personal events (see Supplementary Table 1 ). Since its development, this LEs scale has been used widely across research ( Zhu et al, 1998 ; Liu et al, 2009 ; Chen et al, 2012 ; Xu et al, 2013 ; Wang et al, 2017 ). In this study, participants were asked whether they had experienced one or more of the listed LE(s) during the 12 months before the baseline period.…”

Section: Participants and Methodsmentioning

confidence: 99%

“…Based on previous studies ( Liu et al, 2009 ; Chen et al, 2012 ; Li et al, 2021 ), LEs were classified as “positive” or “negative” on this scale (see Supplementary Table 2 ). The scores for positive and negative LEs were calculated based on the summation of the severity scores of the respective positive and negative LEs.…”

Section: Participants and Methodsmentioning

confidence: 99%

The Association Between Life Events and Incidence of Hypertension Among Government Employees in China: A Prospective Cohort Study

Ouyang

Cheng

et al. 2022

Front. Psychol.

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BackgroundHypertension (HTN) is a global public health concern. However, the association between life events (LEs) and HTN is complex. Thus, we conducted a prospective cohort study to explore this complex association.MethodsA total of 8,077 government employees without HTN were recruited through cluster sampling between 2018 and 2019 in Hunan Province, China. At baseline, information regarding sociodemographic characteristics, LEs, and behavioral factors was collected. After the 1-year follow-up, the participants were revisited to obtain the HTN diagnosis. Crude and adjusted Poisson regression models were constructed to calculate the incidence rate ratios (IRRs) and 95% confidence intervals (CIs). Cubic regression spline models were used to visualize the trends between LEs and HTN IRRs. Interactive and subgroup analyses were also performed.ResultsThe 1-year HTN incidence rate among government employees in Hunan province was 4.30% (95% CI: 3.86–4.74%). LEs were associated with a higher HTN risk (IRR, 1.02; 95% CI, 1.00–1.04). When calculating positive and negative LEs scores separately, only the latter was a risk factor for HTN incidence (IRR, 1.04; 95% CI, 1.03–1.06); conversely, positive LEs reduced the risk (IRR, 0.90; 95% CI, 0.85–0.96). Compared with patients in the lowest quartile of LEs score, those in quartiles two (IRR, 1.28; 95% CI, 0.96–1.71), three (IRR, 1.43; 95% CI, 1.04–1.96), and four (IRR, 1.73; 95% CI, 1.26–2.37) were at progressively higher risk. In restricted spline curves, a non-linear association was noted between LEs and HTN risk. Regarding the subcategories of LEs, work-related LEs, personal LEs, and all subcategories of negative LEs were associated with an increased risk of HTN. However, among positive LEs, only the family-related cases were associated with a lower risk of HTN.ConclusionLEs had a non-linear association with an increased risk of HTN. Negative LEs were risk factors for HTN incidence, whereas positive LEs reduced the risk of HTN. Thus, the importance of LEs should be highlighted in the development of HTN prevention strategies and initiatives.

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Mental Health Status and Factors that Influence the Course of Graves’ Disease and Antithyroid Treatments

Abstract: Enhancing positive coping strategies and social support is important to improve mental health in GD patients, to avoid compromising work-related performance and endangering a patient's social status.

Cited by 8 publications

References 12 publications

Is Hyperthyroidism a Possible Etiology of Early Onset Dementia?

Is Hyperthyroidism a Possible Etiology of Early Onset Dementia?

The relationship between atherosclerotic disease and relapse during ATD treatment

The Association Between Life Events and Incidence of Hypertension Among Government Employees in China: A Prospective Cohort Study

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