Mental Response to Added Thiamine

Harrell, Ruth F.

doi:10.1093/jn/31.3.283

Cited by 46 publications

(16 citation statements)

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“…For example, in a double-blind trial thiamine supplementation was found to improve mood, although as judged by the usual physiological index of bodily status, erythrocyte transketolase activation, the population was well nourished prior to supplementation (96) . Similarly, Harrell (30) reported that improved cognition resulted from thiamine supplements in children whose diet already supplied the recommended level. In children, although the findings require clarification, an improvement in non-verbal intelligence scores in at least some of the children who received micronutrient supplements has been reported in a number of double-blind studies (81) .…”

Section: Discussionmentioning

confidence: 99%

Vitamins and neural and cognitive developmental outcomes in children

Benton

2011

Proc. Nutr. Soc.

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The role of vitamin status in the development of the brain and the subsequent functioning of the brain was considered. There are data with a range of vitamins, from animal studies and human studies in developing countries, suggesting that a clinical deficiency during the critical period when the brain is developing causes permanent damage. To date there is, however, with the exception of cases of clinical deficiency such as those that might be associated with a vegan diet, little evidence that variations in the diet of those living in industrialised countries have a lasting developmental influence. Similarly, later in life clinical deficiencies of various vitamins disrupt cognition although there is to date limited evidence that variations in the intake of single vitamins in industrialised societies influence functioning. It may well be, however, unreasonable to expect that vitamins examined in isolation will be associated with differences in cognitive functioning. The output of the brain reflects millions of metabolic processes, each potentially susceptible to any of a range of vitamins. A diet poor in one respect is likely to be poor in other respects as well. As such, the preliminary reports in double-blind placebo-controlled trials that aspects of cognition and behaviour respond to supplementation with multi-micronutrients may indicate the way forward.

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Section: Discussionmentioning

confidence: 99%

Vitamins and neural and cognitive developmental outcomes in children

Benton

2011

Proc. Nutr. Soc.

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“…As Heseker et al (1990) found an improvement in mood using a 3-mg supplement, it seems likely that a dose lower than that used in the present experiment would have proved to have been effective. Harrell (1946) examined children who ate a diet that supplied 1 mg thiamine a day, to boys for whom the Recommended Daily Allowance (RDA) was 1 mg a day, and to girls for whom it was 0.9 mg. A priori, this diet would have been said to supply an adequate amount of thiamine. Yet after taking 2 mg thiamine, each day for a year, in a double-blind study, those who took the vitamin were significantly taller, had better eye-sight, quicker reaction times, and scored better on tests of memory and intelligence.…”

Section: Discussionmentioning

confidence: 99%

Thiamine supplementation mood and cognitive functioning

1997

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One hundred and twenty young adult females took either a placebo or 50 mg thiamine, each day for 2 months. Before and after taking the tablets, mood, memory and reaction times were monitored. An improvement in thiamine status was associated with reports of being more clearheaded, composed and energetic. The taking of thiamine had no influence on memory but reaction times were faster following supplementation. These influences took place in subjects whose thiamine status, according to the traditional criterion, was adequate.

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“…There are few similar studies with which to compare these findings, as most studies of micro nutrient supplementation have examined their impact for weeks or at the most a few months. A rare exception is Harrell [26], who gave thiamin supplements for a year to children whose diet, as judged by the RDA, supplied suffi cient of this vitamin. In this double-blind study after a year those taking thiamin were significantly taller, had quicker reaction times and scored better on tests of mem ory and intelligence.…”

Section: Discussionmentioning

confidence: 99%

Vitamin Supplementation for 1 Year Improves Mood

1995

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The possibility that the taking of vitamin supplements may influence mood was explored. One hundred and twenty-nine young healthy adults took either 10 times the recommended daily dose of 9 vitamins, or a placebo, under a double-blind procedure, for a year. Males taking the vitamins differed from those taking the placebo in that they reported themselves as feeling more ‘agreeable’ after 12 months. After 12 months the mood of females taking the vitamin supplement was significantly improved in that they felt more ‘agreeable’, more composed and reported better mental health. These changes in mood after a year occurred even though the blood status of 9 vitamins reached a plateau after 3 months: this improvement in mood was associated in particular with improved ribofiavin and pyridoxine status. In females baseline thiamin status was associated with poor mood and an improvement in thiamin status after 3 months was associated with improved mood.

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Mental Response to Added Thiamine

Cited by 46 publications

References 0 publications

Vitamins and neural and cognitive developmental outcomes in children

Vitamins and neural and cognitive developmental outcomes in children

Thiamine supplementation mood and cognitive functioning

Vitamin Supplementation for 1 Year Improves Mood

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