“…Many studies have demonstrated inverse associations between inter-pandemic perceived social support levels and various mental health symptoms during the pandemic ( Bik-Multanowska et al, 2022 , Iob et al, 2020 , McLean et al, 2022 , Rhubart and Kowalkowski, 2022 ). There is also some data demonstrating associations between greater perceived social support before the pandemic and a lower prevalence of mental health symptoms during the pandemic ( Ehrler et al, 2022 , Herzog et al, 2022 , Hill et al, 2021 , Lee et al, 2020 ; C. H. Wang et al, 2021 ; Xu et al, 2020 ). However, there remains limited data on the impact of pre- or inter-pandemic perceived social support on mental health following Big Events, including the COVID-19 pandemic, among PWUD.…”