Mental Stress and Cognitive Deficits Management

Al-Shargie, Fares; Taresh, Sahar Mohammed; Al-Ezzi, Abdulhakim

doi:10.3390/brainsci14040316

Brain Sciences

2024

DOI: 10.3390/brainsci14040316

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Mental Stress and Cognitive Deficits Management

Fares Al-Shargie,

Sahar Mohammed Taresh,

Abdulhakim Al-Ezzi

Abstract: Mental stress is a prevalent aspect of contemporary life that affects individuals from diverse backgrounds [...]

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2024

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In silico and in vivo anti-stress potential of Stachytarpheta cayennensis (Verbenaceae) in mice

Akanmu,

Akinpelu,

Aliyu

et al. 2024

PSNNJP

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Background: Stachytarpheta cayennensis is locally used as an antistress agent but no scientiﬁc rationale for its use. Hence, this study evaluated the antistress potential of ethanol leaf extract of Stachytarpheta cayennensis (ELSC) in mice. Methods: The stress induced anxiety was assessed using elevated plus maze following acute restraint stress in mice. The in silico studies of previously reported compounds from Stachytarpheta cayennensis (S. cayennensis) were also carried out. Results and discussion: There was signiﬁcant (p<0.001) increase in anxiety status of stressed control mice compared to the unstressed control suggesting stress induction. However, ELSC stressed at 125 and 250 mg/kg and diazepam stressed control signiﬁcantly (p<0.001) reduced the anxiety indices of mice compared to the stressed control group suggesting the reversal of stress-induced anxiety in mice. The results of in silico studies revealed betulinic acid was the most favourable compound in terms of pharmacokinetics, toxicity proﬁle and binding aﬃnity. The post docking analysis showed that betulinic acid and the positive antistress drug (diazepam) interacted with amino acid residues of the target receptor protein active pockets. Moreso, betulinic acid has a stronger binding aﬃnity (-7.8Kcal/Mol) compared to diazepam (-6.9 Kcal/Mol), suggesting that betulinic acid may be a more eﬀective antistress agent than diazepam. Conclusion: This study therefore, concluded that betulinic acid may at least in part be responsible for the observed antistress eﬀect of Stachytarpheta cayennensis. However, further studies may be carried out on the antistress potential of betulinic acid.

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In silico and in vivo anti-stress potential of Stachytarpheta cayennensis (Verbenaceae) in mice

Akanmu,

Akinpelu,

Aliyu

et al. 2024

PSNNJP

View full text Add to dashboard Cite

show abstract

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Mental Stress and Cognitive Deficits Management

Abstract: Mental stress is a prevalent aspect of contemporary life that affects individuals from diverse backgrounds [...]

Cited by 1 publication

References 19 publications

<i>In silico</i> and <i>in vivo</i> anti-stress potential of <i>Stachytarpheta cayennensis</i> (Verbenaceae) in mice

<i>In silico</i> and <i>in vivo</i> anti-stress potential of <i>Stachytarpheta cayennensis</i> (Verbenaceae) in mice

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