Mentha piperita Oil Exerts an Antiepileptic Effect in Pilocarpine and Pentylenetetrazol-Induced Seizures in Mice

Abstract

Introduction. Epilepsy is a progressive, chronic neurological disorder characterized by recurrent seizures. Peppermint (Mentha piperita L.) (MP) is one of the most commonly ingested herbal teas or tisanes with a single component. Aim. We aimed to assess the potential antiepileptic and neuroprotective features of MP essential oil (MPO) in pilocarpine (P) and pentylenetetrazol (PTZ) models of epilepsy. Methods. The study used eight groups of mice to assess the anticonvulsant activity of MPO in both the P and PTZ acute models in mice. P (350 mg/kg, i.p.) was given 30 minutes after MPO (1.6, 3.2, and 6.4 ml/kg, i.p.). As a positive control group, diazepam (1 mg/kg, i.p) was used. PTZ (95 mg/kg, i.p.) was given 30 minutes after MPO (6.4 ml/kg, i.p.). The first convulsion’s latency time, the number of convulsions, the latency time to death, and the percentage of deaths were calculated in all groups. Results. MPO significantly ( P < 0.05 ) increases the first convulsion’s latency time and the death’s latency time. Moreover, the essential oil significantly decreases the number of convulsions and reduces the mortality rate compared to the negative control group. Conclusion. MPO at 3.2 and 6.4 ml/kg doses can reduce the percentage and the number of convulsions and increase the latency time of both the first convulsion and death so that it can be used as a supplement in the treatment of epilepsy.

Effect of quercetin against pilocarpine-induced epilepsy in mice

“…[ 30 31 ] Prostaglandins have been demonstrated to enhance glutamatergic transmission and inhibit GABAergic transmission in specific brain regions. [ 19 ] Imbalances in inhibitory and excitatory neurotransmission are thought to be related to the propagation and development of seizures. [ 32 ] PGE2 can modulate the activity of ion channels, including potassium and calcium channels, which play crucial roles in regulating neuronal excitability.…”

Neuroprotective Effect of Brivaracetam and Perampanel Combination on Electrographic Seizures and Behavior Anomalies in Pentylenetetrazole-Kindled Mice

“…Co. Ltd., Japan) was solubilized in 1% tween to use its dose of 0.25 mg/kg . Diazepam, available as a commercial formulation named Valium, from Roche Pharma was diluted in distilled water, and its dose of 1 mg/kg was used …”

“… 24 Diazepam, available as a commercial formulation named Valium, from Roche Pharma was diluted in distilled water, and its dose of 1 mg/kg was used. 25 …”

Descripción teórica de la detección electroquímica del fármaco pilocarpina, asistida por el compuesto de colorante escuárico con el oxihidróxido de vanadio (III)

“…Poseyendo grupos electroactivos (el núcleo imidazólico y fragmento de butirolactona), la pilocarpina se puede detectar por vía electroquímica [25][26][27]. Aunque los métodos, envolviendo la electrooxidación sean posibles, los catódicos son más preferibles y más fáciles de realizar en práctica.…”