MEOX1 triggers myofibroblast apoptosis resistance, contributing to pulmonary fibrosis in mice
Ling Jin,
Bo Bao,
Xiao‐Ting Huang
et al.
Abstract:The apoptosis resistance of myofibroblasts is a hallmark in the irreversible progression of pulmonary fibrosis (PF). While the underlying molecular mechanism remains elusive. In this study, we unveiled a previously unrecognized mechanism underlying myofibroblast apoptosis resistance during PF. Our investigation revealed heightened expression of mesenchyme homeobox 1 (MEOX1) in the lungs of idiopathic pulmonary fibrosis (IPF) patients and bleomycin‐induced PF mice. Silencing MEOX1 significantly attenuated PF pr… Show more
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