Mercurochrome allergy: concurrence of 2 hypersensitivity mechanisms in the same patient

Hernandez, A. Peláez; Aznar, José Vicente Brasó; Martinez, German; Puchades, A. Rochina; Baixauli, E. Burches

doi:10.1111/j.1600-0536.1994.tb00735.x

Cited by 12 publications

(3 citation statements)

References 10 publications

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“…In prick tests 3 control persons did not react to 2 % merbromin (Hernández et al 1994). Such immediate reactions were also described in other cases (Camarasa 1976, Corrales Torres and de Corres 1985, Sanz et al 1989.…”

Section: Effects In Manmentioning

confidence: 54%

Merbromin [MAK Value Documentation, 2001]

2012

The MAK‐Collection for Occupational Health and Safety

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Section: Effects In Manmentioning

confidence: 54%

Merbromin [MAK Value Documentation, 2001]

2012

The MAK‐Collection for Occupational Health and Safety

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“…In European Countries, merbromin is still available in Belgium, Greece, and Spain, as well as in Italy. Probably for this reason most of the cases of merbromin‐induced ACD were reported from the mid‐1970s to the end of the 1990s 2,4‐8 . In all these patients patch testing results were positive to mercury in at least one of its three chemical forms (metallic mercury, organic mercury, and mercury salts), therefore suggesting that the mercurial component was responsible for merbromin sensitization.…”

Section: Discussionmentioning

confidence: 99%

Contact allergy to merbromin: A forgotten organomercuric allergen?

et al. 2022

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Written informed consent was obtained from the patient for publication of this case report and any accompanying images. AUTHOR CONTRIBUTIONS Astrid Herzum: Conceptualization (equal); data curation (equal); formal analysis (equal); investigation (equal); methodology (equal); project administration (equal); supervision (equal); validation (equal); visualization (equal); writingoriginal draft (equal); writingreview and editing (equal). Emanuele Cozzani: Conceptualization (equal); data curation (equal); supervision (equal); validation (equal). Aurora Parodi: Conceptualization (equal); data curation (equal); resources (equal); supervision (equal); validation (equal); writingreview and editing (equal). Rosella Gallo: Conceptualization (equal); data curation (equal); formal analysis (equal); investigation (equal); methodology (equal); project administration (equal); supervision (equal); validation (equal); visualization (equal); writingoriginal draft (equal); writingreview and editing (equal).

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“…In a study with 2776 consecutive patients, 13.2 % were positive to ethylmercury(II) chloride, 11.8 % to thimerosal, and 8.9 % to metallic mercury [119]. Hypersensitivity was also described after dermal application of mercurochrome [120,121] and in connection with mercury in tattoos [122]. However, occupational contact dermatitis from mercury is considered to be rare [20], and a positive patch test for mercury is generally without clinical consequences [115].…”

Section: Hypersensitivity In Humansmentioning

confidence: 99%

Immunological effects of mercury (IUPAC Technical Report)

Schwenk

Klein

Templeton

2009

Pure and Applied Chemistry

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Republication or reproduction of this report or its storage and/or dissemination by electronic means is permitted without the Immunological effects of mercury (IUPAC Technical Report)Abstract: Various chemical species of mercury differ considerably with regard to their route of absorption and their distribution in the body, yet many of them and their metabolites exhibit high-affinity binding to sulfanyl groups of proteins. Among all metals, mercury appears to have the most diverse effects on the immune system. Depending on the animal species and experimental conditions, mercury compounds may cause immunosuppression or immunostimulation, autoimmune reactions, or hypersensitivity. Mercury-sensitive strains of rats and mice are often used as model organisms to study the time course and events in autoimmunity. Within about 14 days after onset of oral mercury(II) exposure, levels of immunoglobulins E and G (IgE and IgG) increase, including autoantibodies to biomolecules such as laminin and fibrillarin. Antigen-antibody complexes are formed and are the cause of subsequent autoimmune diseases of blood vessels and organs. Mercury may induce local mercury hypersensitivity in humans, but the evidence for a role of mercury in autoimmune disease of humans is at best weak. Models for the immune effects of mercury are presented on the basis of current knowledge.

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Mercurochrome allergy: concurrence of 2 hypersensitivity mechanisms in the same patient

Cited by 12 publications

References 10 publications

Merbromin [MAK Value Documentation, 2001]

Merbromin [MAK Value Documentation, 2001]

Contact allergy to merbromin: A forgotten organomercuric allergen?

Immunological effects of mercury (IUPAC Technical Report)

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