Mercury and heavy metal profiles of maternal and umbilical cord RBCs in Japanese population

Sakamoto, Mineshi; Murata, Katsuyuki; Kubota, Machi; Nakai, Kunihiko; Satoh, Hiroshi

doi:10.1016/j.ecoenv.2009.09.010

Cited by 67 publications

(34 citation statements)

References 57 publications

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“…Nonetheless, the mean hair-to-blood ratio of our study within the dynamic range was similar to recent studies (Berglund et al, 2005;Budtz-Jørgensen et al, 2004;Sakamoto et al, 2007), as described above. In addition, as maternal MeHg is selectively transferred to the fetus via the placenta (Sakamoto et al, 2010), such pregnant women were not included among our subjects. The measurement bias would have been minimized because the T-Hg levels were not analyzed in all subjects until the end of the washout period.…”

Section: Discussionmentioning

confidence: 99%

Hair-to-blood ratio and biological half-life of mercury: experimental study of methylmercury exposure through fish consumption in humans

et al. 2012

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Section: Discussionmentioning

confidence: 99%

Hair-to-blood ratio and biological half-life of mercury: experimental study of methylmercury exposure through fish consumption in humans

et al. 2012

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“…A range of follow-up studies and reassessment of outcomes from the Minamata area, which also includes control groups from Japan with lower exposure, have been published since the assessment by JECFA (Futatsuka et al, 2005;Ninomiya et al, 2005;Uchino et al, 2005;Ekino et al, 2007;Yorifuji et al, 2008Yorifuji et al, , 2009aYorifuji et al, , 2009bYorifuji et al, , 2011Gilbertson, 2009;Sakamoto et al, 2010). However, the previous methylmercury exposure has been higher than in the Faroese and Seychelles cohorts on which the JECFA PTWI is based.…”

Section: Neurotoxicity In Adultsmentioning

confidence: 99%

Scientific Opinion on the risk for public health related to the presence of mercury and methylmercury in food

2012

EFS2

465

160

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EFSA was asked by the European Commission to consider new developments regarding inorganic mercury and methylmercury toxicity and evaluate whether the Joint FAO/WHO Expert Committee on Food Additives (JECFA) provisional tolerable weekly intakes for methylmercury of 1.6 µg/kg body weight (b.w.) and of 4 µg/kg b.w. for inorganic mercury were still appropriate. In line with JECFA, the CONTAM Panel established a tolerable weekly intake (TWI) for inorganic mercury of 4 µg/kg b.w., expressed as mercury. For methylmercury, new developments in epidemiological studies from the Seychelles Child Developmental Study Nutrition Cohort have indicated that n-3 long-chain polyunsaturated fatty acids in fish may counteract negative effects from methylmercury exposure. Together with the information that beneficial nutrients in fish may have confounded previous adverse outcomes in child cohort studies from the Faroe Islands, the Panel established a TWI for methylmercury of 1.3 µg/kg b.w., expressed as mercury. The mean dietary exposure across age groups does not exceed the TWI for methylmercury, with the exception of toddlers and other children in some surveys. The 95 th percentile dietary exposure is close to or above the TWI for all age groups. High fish consumers, which might include pregnant women, may exceed the TWI by up to approximately six-fold. Unborn children constitute the most vulnerable group. Biomonitoring data from blood and hair indicate that methylmercury exposure is generally below the TWI in Europe, but higher levels are also observed. Exposure to methylmercury above the TWI is of concern. If measures to reduce methylmercury exposure are considered, the potential beneficial effects of fish consumption should also be taken into account. Dietary inorganic mercury exposure in Europe does not exceed the TWI, but inhalation exposure of elemental mercury from dental amalgam is likely to increase the internal inorganic mercury exposure; thus the TWI might be exceeded. This opinion focuses only on the risks related to dietary inorganic mercury and methylmercury exposure and does not assess the nutritional benefits linked to certain foods (e.g. fish and other seafood).A call for annual collection of chemical contaminant occurrence data in food and feed, including mercury, was issued by EFSA in December 2010. In response, EFSA received 59 820 results on mercury in food from 20 European countries, mainly covering the period from 2004 to 2011. A total number of 59 650 results were described with sufficient detail to be used in the statistical analysis of the respective food groups; 98.2 % of the samples were for total mercury, 1.8 % for methylmercury and three samples for inorganic mercury.All the 20 food groups available at the first level of FoodEx were covered in the current data collection. The food groups 'Fish and other seafood' and 'Meat and meat products' dominated the food product coverage with 36.8 % and 17.6 % respectively. These were followed by 'Grain and grain-based products' at 7.8 % and 'Vegetables an...

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“…In particular, the development of the nervous system of the fetus is affected irreversibly by methylmercury through the exposure of women during pregnancy (13, 31). The transfer of metals from the mother to the fetus is possible through the placenta, and carryover from breast milk can produce some symptoms in early childhood such as neuropsychological disorders and urinary tract defects (1, 11,12,17,40,42). Problems more frequently associated with heavy metal exposure from food include long-term effects in several tissues, in particular mutagenicity (25, 39), carcinogenicity (3 , 8), teratogenicity (43), immunotoxicity (36), and endocrine disruption (34).…”

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Heavy Metals in Canned Tuna from Italian Markets

Russo¹,

Voi

Simone³

et al. 2013

Journal of Food Protection

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Fish is a good source of nutrients for humans but can pose a risk to human health because of the possible presence of some xenobiotics such as heavy metals and persistent organic contaminants. Constant monitoring is needed to minimize health risks and ensure product quality and consumer safety. The aim of the present study was to use atomic absorption spectrometry to determine the concentrations of some heavy metals (Hg, Pb, and Cd) in tuna packaged in different kinds of packages (cans or glass) in various countries (Italy and elsewhere). Concentrations of Cd and Hg were within the limits set by European Commission Regulation (EC) No 1881/2006 and in many samples were below the detection limit. Pb concentrations exceeded European limits in 9.8% of the analyzed samples. These results are reassuring in terms of food safety but highlighted the need to constantly monitor the concentrations of heavy metals in fish products that could endanger consumer health.

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Mercury and heavy metal profiles of maternal and umbilical cord RBCs in Japanese population

Cited by 67 publications

References 57 publications

Hair-to-blood ratio and biological half-life of mercury: experimental study of methylmercury exposure through fish consumption in humans

Hair-to-blood ratio and biological half-life of mercury: experimental study of methylmercury exposure through fish consumption in humans

Scientific Opinion on the risk for public health related to the presence of mercury and methylmercury in food

Heavy Metals in Canned Tuna from Italian Markets

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