Mercury and selenium levels, and their molar ratios in several species of commercial shrimp in Japan regarding the health risk of methylmercury exposure

Hoang, Van Anh Thi; Sakamoto, Mineshi; Yamamoto, Megumi

doi:10.2131/jts.42.509

Cited by 10 publications

(6 citation statements)

References 17 publications

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“…Similarly, Hg concentrations in sardines were lower than the Hg levels in canned sardines (117 ng/g, 141 ng/g, and 143 ng/g) reported by Boadi et al (2011). The current study found that the percentage of MeHg in T-Hg in canned fish samples ranged from 90.4% to 100%, which was consistent with levels found in fish, squid and shrimp in previous studies (Bloom, 1992;Yoshimoto et al, 2016;Hoang et al, 2017).…”

Section: Discussionsupporting

confidence: 88%

“…Recently, we reported that T-Hg, MeHg and Se concentrations in commercial shrimp in Japan, which included Vietnamese black tiger shrimp, were lower than the Japanese regulated level (Notice Kannyu No.99, 1973) of 300 ng/g for MeHg in fish (Hoang et al, 2017). Moreover, the average Se/Hg molar ratios in the muscle of commercial shrimp were comparatively high (in the range of 16-106).…”

Section: Discussionmentioning

confidence: 85%

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Hair mercury levels in relation to fish consumption among Vietnamese in Hanoi

Hoang

Do²,

Agusa

et al. 2017

J. Toxicol. Sci.

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-People are exposed to methylmercury (MeHg) mainly through fish consumption, which is increasing in Vietnam. However, little information is available on estimating the health risk of MeHg exposure through fish consumption in Vietnam. The present study examined the association between mercury (Hg) levels in hair and selenium (Se) levels in toenails of 196 Vietnamese people and their fish consumption, using a dietary questionnaire to obtain information pertinent for assessing health risk owing to MeHg exposure. The geometric mean of Hg levels in the hair of males and females was 617 ng/g and 575 ng/g, respectively. We found that Hg levels in the hair of 98% of the Vietnamese study subjects were lower than the provisional tolerable weekly intake for MeHg (1.6 μg Hg/kg body weight; which is equivalent to a hair Hg concentration of approximately 2,300 ng/g, with an uncertainty factor of 6.4). There were significant differences in the age-adjusted geometric mean of Hg levels found in hair from females related to their frequency of freshwater fish consumption. The levels of Hg in hair and Se in toenails increased with an increased frequency of marine fish consumption, and both showed a significant positive correlation in subjects who consumed marine fish ≥ once/week. This is the first cross-sectional study to investigate the association between hair Hg levels and fish consumption in Vietnam. These findings provide valuable information for future assessments of the health risk of MeHg exposure through fish consumption in Vietnam.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 85%

Hair mercury levels in relation to fish consumption among Vietnamese in Hanoi

Hoang

Do²,

Agusa

et al. 2017

J. Toxicol. Sci.

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“…T‐Hg concentrations in blood and sciatic nerve were measured with a direct thermal decomposition Hg analyzer (SP‐3D and MA‐3000; Nippon Instruments, Tokyo, Japan) as previously described (Yamamoto et al, ; Yamamoto et al, ). T‐Hg and MeHg contents in brain tissue were measured using a protocol we developed previously (Hoang, Do, et al, ; Hoang, Sakamoto, & Yamamoto, ; Miyamoto, Kuwana, Ando, Yamamoto, & Nakano, ; Yoshimoto et al, ). The samples were solubilized with 0.1% Cys solution (1 mL) and 5 m NaOH (1 mL), then incubated at 80°C for 1 hour with vortexing every 10 minutes.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of neurobehavioral impairment in methylmercury‐treated KK‐Ay mice by dynamic weight‐bearing test

Yamamoto

Motomura

Yanagisawa

et al. 2018

J of Applied Toxicology

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Methylmercury (MeHg) is known to cause neurobehavioral impairment in human and experimental animals. We previously reported that MeHg (5 mg Hg/kg) induced severe neurobehavioral dysfunction in 4-week-old KK-Ay mice, although it is difficult to evaluate quantitatively the neurobehavioral impairment in MeHg-treated KK-Ay mice because of their obesity. The aim of this study was to evaluate MeHg-induced neurobehavioral dysfunction in KK-Ay mice using the dynamic weight-bearing test, which analyzes the animal's weight distribution between the four limbs. Male 12-week-old KK-Ay mice were treated with MeHg (5 mg Hg/kg) three times per week for 5 weeks. Body weight loss began after approximately 2 weeks of MeHg treatment, and decreased significantly at 4 weeks. Seven of the nine MeHg-treated mice exhibited overt neurological symptoms such as ataxia and gait disturbance. The weight-bearing load was lower for the forelimb than for the hindlimb at baseline and until 1 week after MeHg treatment was initiated. In weeks 2-4, the dynamic weight-bearing loads on the forelimb and hindlimb were similar. The load on the forelimb exceeded the load on the hindlimb after 5 weeks of treatment. This finding indicates that the dynamic weight-bearing test is useful for semi-quantitative evaluation of neurobehavioral impairment in MeHg-treated rodents, and is less stressful for the animals. Infiltration of CD204-positive macrophages was observed in the sciatic nerve of MeHg-treated mice, suggesting that CD204 can serve as a useful marker of tissue injury in peripheral nerves and a possible target in regenerating peripheral nerves and controlling neuropathies.

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“…The mobility, toxicity, and bioavailability of trace elements depend strongly on their particular existing forms in a given system. For example, organic mercury, especially MeHg, is more toxic to marine animals than inorganic mercury due to its facilitated penetration of biological membranes, its high stability, and biomagnification capacity (Hoang, Sakamoto, & Yamamoto, ). One of the toxic aspects of mercury is attributed to the very strong affinity between Hg 2+ or MeHg + and Se 2− .…”

Section: Introductionmentioning

confidence: 99%

“…Based on this affinity, the toxic mechanisms of mercury are strongly related to the concentration of selenium in ecosystems and organisms. It could have an increasing potential for the toxic effects when the molar mercury concentration exceeds that of selenium, that is, Se:Hg < 1 (Hoang et al., ; Mulder et al., ). Therefore, the existing forms and proportions along with the mutual bioaccumulation of selenium and mercury in organisms and the environment have attracted extensive attention of researchers.…”

Section: Introductionmentioning

confidence: 99%

Species and correlations between selenium and mercury in fishpond ecosystems

Wang

Nan

et al. 2019

Water Environment Research

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The chemical species and contents of selenium and mercury in water, sediments, and crucian carps collected from three wild and three aquaculture fishponds in Tianjin, China, were determined, and the interaction between selenium and mercury in water was also investigated by the calorimetry method. The results revealed that the average contents of total selenium (TSe) and total mercury (THg) in each item of the wild areas were higher than in those of the aquaculture areas, and significant differences (95% confidence) were presented for THg both in the sediments and crucian carps. The molar ratios between TSe and THg in all investigated fishponds were far higher than 1, indicating good protective effects of selenium on mercury toxicity. Obviously, negative correlations (r > 0.9993) were found between TSe and THg in water. The antagonism of selenium on mercury in water was confirmed to mainly result from the reaction between selenate and Hg2+ to form an insoluble selenium–mercury oxygenated compound, by which the addition of selenate into the water of fishponds would reduce the environmental risk of mercury. Practitioner points Se and Hg in different fishpond ecosystems were investigated and compared. Direct evidence was provided for the interaction between Se and Hg in water. The addition of Se(VI) into fishpond ecosystems would reduce the environmental risk of Hg.

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Mercury and selenium levels, and their molar ratios in several species of commercial shrimp in Japan regarding the health risk of methylmercury exposure

Cited by 10 publications

References 17 publications

Hair mercury levels in relation to fish consumption among Vietnamese in Hanoi

Hair mercury levels in relation to fish consumption among Vietnamese in Hanoi

Evaluation of neurobehavioral impairment in methylmercury‐treated KK‐Ay mice by dynamic weight‐bearing test

Species and correlations between selenium and mercury in fishpond ecosystems

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