Mercury concentrations in fish from three major lakes in north Mississippi: Spatial and temporal differences and human health risk assessment

Wolff, Steven W.; Brown, Garry; Chen, Jingjing; Meals, Keith O.; Thornton, Cammi; Brewer, Steve; Cizdziel, James V.; Willett, Kristine L.

doi:10.1080/15287394.2016.1194792

Cited by 17 publications

(5 citation statements)

References 27 publications

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“…The most common route of human exposure, however, is via the ingestion of food, primarily fish, contaminated with MeHg (Nunes et al 2014; 2014; Wolff et al, 2016; Lopez-Barrera and Barragan-Gonzalez, 2016). The flesh of large predatory fish, such as northern pike, swordfish, shark, and some species of tuna may contain high levels of CH 3 Hg + and represents a major source of Hg exposure (Siedlikowski et al 2016; Burger and Gochfeld 2011).…”

Section: Aging and Exposure To Mercurymentioning

confidence: 99%

The aging kidney and the nephrotoxic effects of mercury

Bridges

Zalups

2017

Journal of Toxicology and Environmental Health, Part B

104

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Owing to advances in modern medicine, life expectancies are lengthening and leading to an increase in the population of older individuals. The aging process leads to significant alterations in many organ systems, with the kidney being particularly susceptible to age-related changes. Within the kidney, aging leads to ultrastructural changes such as glomerular and tubular hypertrophy, glomerulosclerosis, and tubulointerstitial fibrosis, which may compromise renal plasma flow (RPF) and glomerular filtration rate (GFR). These alterations may reduce the functional reserve of the kidneys making them more susceptible to pathological events when challenged or stressed, such as following exposure to nephrotoxicants. An important and prevalent environmental toxicant that induces nephrotoxic effects is mercury (Hg). Since, exposure of normal kidneys to mercuric ions might induce glomerular and tubular injury, aged kidneys, which may not be functioning at full capacity, may be more sensitive to the effects of Hg than normal kidneys. Age-related renal changes and the effects of Hg in the kidney have been characterized separately. However, little is known regarding the influence of nephrotoxicants, such as Hg, on aged kidneys. The purpose of this review was to summarize known findings related to exposure of aged and diseased kidneys to the environmentally relevant nephrotoxicant, Hg.

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Section: Aging and Exposure To Mercurymentioning

confidence: 99%

The aging kidney and the nephrotoxic effects of mercury

Bridges

Zalups

2017

Journal of Toxicology and Environmental Health, Part B

104

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“…The soil in this region is highly erodible, and the erosion rate has been recognized as one of the highest in the nation [23]. This lake has significant natural and recreational resources; however, it is impaired by mercury, and a fish consumption advisory was issued by the Mississippi Department of Environmental Quality (MDEQ) in 1995, which may not be sufficiently protective [24]. In order to reduce the mercury level in the lake, mercury TMDL has been established in the lake watershed [25].…”

Section: Study Sitementioning

confidence: 99%

Three-Dimensional Numerical Modeling of Flow Hydrodynamics and Cohesive Sediment Transport in Enid Lake, Mississippi

et al. 2022

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Enid Lake is one of the largest reservoirs located in Yazoo River Basin, the largest basin in the state of Mississippi. The lake was impounded by Enid Dam on the Yocona River in Yalobusha County and covers an area of 30 square kilometers. It provides significant natural and recreational resources. The soils in this region are highly erodible, resulting in a large amount of fine-grained cohesive sediment discharged into the lake. In this study, a 3D numerical model was developed to simulate the free surface hydrodynamics and transportation of cohesive sediment with a median diameter of 0.0025 to 0.003 mm in Enid Lake. Flow fields in the lake are generally induced by wind and upstream river inflow, and the sediment is also introduced from the inflow during storm events. The general processes of sediment flocculation and settling were considered in the model, and the erosion rate and deposition rate of cohesive sediment were calculated. In this model, the sediment simulation was coupled with flow simulation. In this research, remote sensing technology was applied to estimate the sediment concentration at the lake surface and provide validation data for numerical model simulation. The model results and remote sensing data help us to understand the transport, deposition and resuspension processes of cohesive sediment in large reservoirs due to wind-induced currents and upstream river flows.

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“…Perez et al (2012) found in Asian community in Philadelphia that although awareness of fish advisories improved, fish consumption remained unchanged. It also needs to be considered that Hg levels in fish may vary significantly among bodies of water across the United States; therefore, published fish advisories may not be appropriate for every location (Wolff et al 2016; Taylor and Williamson 2017).…”

Section: Introductionmentioning

confidence: 99%

Disposition of methylmercury over time in a 75% nephrectomized rat model

Orr

Joshee

Barkin

et al. 2018

Journal of Toxicology and Environmental Health, Part A

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Chronic kidney disease (CKD) is a highly relevant clinical condition that is characterized by the permanent loss of functional nephrons. Individuals with CKD may exhibit impaired renal clearance, which may alter corporal handling of metabolites and xenobiotics. Methylmercury (MeHg) is an important environmental toxicant to which humans are exposed to on a regular basis. Given the prevalence of CKD and ubiquitous presence of MeHg in the environment, it is important to understand how mercuric ions are handled in patients with CKD. Therefore, the purpose of the current study was to characterize the disposition of MeHg over time in a rat model of CKD (i.e., 75% nephrectomized (NPX) rats). Control and NPX rats were exposed intravenously (iv) to a non-nephrotoxic dose of MeHg (5 mg/kg) once daily for1, 2, or 3 d and the amount of MeHg in organs, blood, urine, and feces determined. The accumulation of MeHg in kidneys and blood of controls was significantly greater than that of NPX animals. In contrast, MeHg levels in brain and liver of controls were not markedly different from corresponding NPX rats. In all organs examined, accumulation of MeHg increased over the course of exposure, suggesting that urinary and fecal elimination are not sufficient to fully eliminate all mercuric ions. The current findings are important in that the disposition of mercuric ions in rats with normal renal function versus renal insufficiency following exposure to MeHg for a prolonged period differ and need to be taken into account with respect to therapeutic management.

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Mercury concentrations in fish from three major lakes in north Mississippi: Spatial and temporal differences and human health risk assessment

Cited by 17 publications

References 27 publications

The aging kidney and the nephrotoxic effects of mercury

The aging kidney and the nephrotoxic effects of mercury

Three-Dimensional Numerical Modeling of Flow Hydrodynamics and Cohesive Sediment Transport in Enid Lake, Mississippi

Disposition of methylmercury over time in a 75% nephrectomized rat model

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