Mercury Distribution in the Squirrel Monkey Retina after in Utero Exposure to Mercury Vapor

Warfvinge, Karin; Bruun, Anitha

doi:10.1006/enrs.1999.4029

Cited by 42 publications

(23 citation statements)

References 19 publications

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“…Our data are in line with our previous electroretinogram results showing impairment in retina function of these patients in full field and multifocal ERG measurements [148]. They also agree with morphological and image studies showing the mercury deposits in primates in retina [164,165] and in the human visual cortex [152,[166][167][168].…”

Section: Mercury Vapor Intoxicationsupporting

confidence: 93%

The Visual (dis)Function in Neurological Diseases

Fern

Costa²

2013

J Neurol Neurophysiol

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Section: Mercury Vapor Intoxicationsupporting

confidence: 93%

The Visual (dis)Function in Neurological Diseases

Fern

Costa²

2013

J Neurol Neurophysiol

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“…In recent studies it has been shown that mercury accumulates in the lens, optic nerve, optic disc, retina pigment epithelium, and retina [5]. Ocular findings in patients with chronic exposure to mercury are: discoloration of the cornea and lens, tremor of the eyelids, disturbances of vision and of extraocular muscles, and in very young children a special manifestation of acrodynia that includes photophobia, conjunctivitis, and keratitis [6] can be found.…”

Section: Introductionmentioning

confidence: 99%

Toxic Effects of Chronic Mercury Exposure on the Retinal Nerve Fiber Layer and Macular and Choroidal Thickness in Industrial Mercury Battery Workers

et al. 2014

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BackgroundThe aim of this study was to evaluate the toxic effects of mercury on retinal nerve fiber layer thickness (RNFLT), macular thickness (MT), and choroidal thickness (CT) by using spectral-domain optical coherence tomography (SD-OCT) in battery industry workers who had been chronically exposed to mercury.Material/MethodsBattery factory workers (n=31) and healthy non-factory employee controls (n=15) participated in the study. Participants were divided into 3 groups: Group 1 (n=15) was factory workers who had worked for more than 5 years in a mercury battery factory; Group 2 (n=16) was factory worker who had worked for less than 5 years in a mercury battery factory; and Group 3 (n=15) was healthy non-employees. Systemic symptoms were recorded. Ophthalmic examination included best-corrected visual acuity test, color vision test, full ophthalmologic examination, and SD-OCT of the RNLF, macula, and choroid. To determine mercury exposure, venous blood samples were collected and mercury levels were assessed.ResultsIn our study group the most common systemic symptoms were insomnia (67.7%) and fatigue (67.7%). There were no significant differences between Group 1 and Group 2, but there were significant differences between Group 3 and both Group 1 and Group 2 in best-corrected visual acuity values (1=2<3), color vision scores, blood mercury levels, and duration (mean ±SD, range) of mercury exposure(1>2>3). OCT values of RNFLTs, MTs, and CTs of all 3 groups were statistically different from each another (1<2<3).ConclusionsSD-OCT can be useful for evaluating the toxic effects of chronic exposure to mercury.

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“…A detailed topographic analysis showed Hg deposits in the central and midperipheral parts of the retina but not in the peripheral retina. 42,43 Furthermore, retinal damage has been found in methylmercury intoxication as a reduction of the density in amacrine and bipolar cells, and alterations of the horizontal cells by electrophysiological measurements. 44,45 In humans exposed to Hg vapor, electrophysiological evidence for impairment of the peripheral retina has been found in full-field electroretinogram responses, and in the central retina by multifocal electroretinogram responses.…”

Section: Discussionmentioning

confidence: 99%