Mercury exposure and antioxidant defenses in women: A comparative study in the Amazon

Pinheiro, M.C.N.; Macchi, Barbarella de Matos; Vieira, José Luiz Fernandes; Oikawa, Teiichi; Amoras, Walter Wanderley; Guimarães, G.A.; Costa, Carlos Araújo da; Crespo-López, María Elena; Herculano, Anderson Manoel; Silveira, Luiz Carlos de Lima; Nascimento, José Luíz Martins do

doi:10.1016/j.envres.2007.08.007

Cited by 75 publications

(44 citation statements)

References 36 publications

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“…However, the inhibitory effect of mercury on antioxidative system is described more frequently [4,24]. This effect has been usually mediated by mercury-induced inhibition of antioxidant enzymes and decrease of glutahione [6,9,25,26] or vitamins such as tocopherol [27] and ascorbic acid [28]. In this study, anti-atherosclerotic mechanisms coupled with HDL (indicated by negative linear correlation between HDL-C and IMT) appeared only in non-smokers exposed to mercury vapour.…”

Section: Hg-u Concentration and Carotid Arterial Imt O R I G I N A L mentioning

confidence: 93%

The dependence between urinary mercury concentration and carotid arterial intima-media thickness in workers occupationally exposed to mercury vapour

Skoczyńska¹,

Poręba²,

Steinmentz-Beck³

et al. 2009

International Journal of Occupational Medicine and Environmental Health

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Objectives: Mechanisms of the mercury effect on arterial vessel walls include increased free radicals generation, decreased nitric oxide synthesis and increased reactivity to vasoconstrictors, leading to accelerated development of atherosclerosis and arterial hypertension. The aim of this study was to evaluate the correlation between urinary mercury (Hg-U) concentration and carotid intima-media thickness (IMT) or intraventricular septum diastolic diameter (IVSDD) to find the best markers of mercury cardiovascular toxicity. Materials and Methods: The study included 154 workers of a chemical factory using mercury in chlorine production. Urinary mercury concentration was determined by atomic absorption spectrophotometry. Serum lipids were assessed by routine methods using enzymatic assay. Serum total antioxidant status (TAS) was determined by colorimetry. Measurements of IMT and IVSDD were made by ultrasound imaging using MEDISON SA 9900 PRIME system. Results: The mean Hg-U concentration was 1.9±2.7 μg/g creatinine in women (n = 29) and 5.6±12.2 μg/g creatinine in men (n = 125). In the group of non-smokers (n = 102) there was a positive linear correlation between Hg-U concentration and IMT (r = 0.1728; p < 0.05) and a negative dependence between high density cholesterol (HDL-C) and IMT (r = -0.2109; p < 0.01). The negative linear correlation between serum total antioxidant status (TAS) and carotid IMT (r = -0.2142; p < 0.05), and the positive correlation between HDL-C and TAS (r = 0.1953; p < 0.05) were shown to be valid for the total studied group. Serum lipids in women were normal, but in men the mean triglyceride level was higher than normal. Conclusions: The occupational exposure to mercury vapour remains in a relationship with early, asymptomatic carotid atherosclerosis. The dependence between urinary mercury elimination and carotid intima-media thickness is evidenced in non-smoking workers. Defensive anti-atherosclerotic mechanisms in these workers are strongly related with HDL. In smokers, these protective mechanisms are disturbed.

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Section: Hg-u Concentration and Carotid Arterial Imt O R I G I N A L mentioning

confidence: 93%

The dependence between urinary mercury concentration and carotid arterial intima-media thickness in workers occupationally exposed to mercury vapour

Skoczyńska¹,

Poręba²,

Steinmentz-Beck³

et al. 2009

International Journal of Occupational Medicine and Environmental Health

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“…In a study carried out in the Amazon region, Pinheiro et al (2008) observed a negative correlation between chronic Hg exposure and biochemical parameters related to redox status (activity of the antioxidant enzyme catalase and levels of the tripeptide GSH). A negative association between B-Hg and HHg levels and total GSH was also noted in this study.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of GlutathioneS-transferaseGSTM1andGSTT1Polymorphisms and Methylmercury Metabolism in an Exposed Amazon Population

Barcelos

Marco

Grotto

et al. 2012

Journal of Toxicology and Environmental Health, Part A

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“…Os níveis de mercúrio no cabelo de ribeirinhos da bacia do Tapajós têm sido extensivamente acompanhados por diferentes grupos de pesquisa do Brasil e do exterior 13,14,15,16,17,18,19,20,21,22,23,24,25,26 . Ao longo das últimas duas décadas, essas comunidades têm apresentado concentrações médias de mercúrio no cabelo maiores que aquelas apresentadas por áreas não expostas ao mercúrio, mas abaixo dos níveis que a OMS considera de risco ao sistema nervoso de adultos (50µg/g) 24,26 .…”

Section: Introductionunclassified

Manifestações neurológicas em ribeirinhos de áreas expostas ao mercúrio na Amazônia brasileira

et al. 2013

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No presente estudo, foram avaliados comparativamente os níveis atuais de exposição ao mercúrio e as manifestações neurológicas em ribeirinhos residentes em comunidades situadas no Estado do Pará, Brasil. Participaram do estudo 78 ribeirinhos de Barreiras (bacia do rio Tapajós), 30 de São Luiz do Tapajós (bacia do rio Tapajós) e 49 do Furo do Maracujá (bacia do rio Tocantins). As concentrações de mercúrio total foram quantificadas, em cabelo, pela espectrofotometria de absorção atômica, e a avaliação neurológica foi realizada por meio de testes de rotina. As concentrações de mercúrio nas comunidades do Tapajós foram maiores que as do Tocantins (p < 0,01). A avaliação das alterações neurológicas não mostrou diferença significativa entre as comunidades das áreas expostas e controle para os resultados observados pelo exame neurológico convencional, exceto para desvio da marcha (p < 0,05). Concluiu-se que, apesar dos níveis de exposição ao mercúrio, houve uma baixa frequência de alterações somatossensoriais encontradas por meio de exames neurológicos convencionais.

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Mercury exposure and antioxidant defenses in women: A comparative study in the Amazon

Cited by 75 publications

References 36 publications

The dependence between urinary mercury concentration and carotid arterial intima-media thickness in workers occupationally exposed to mercury vapour

The dependence between urinary mercury concentration and carotid arterial intima-media thickness in workers occupationally exposed to mercury vapour

Evaluation of GlutathioneS-transferaseGSTM1andGSTT1Polymorphisms and Methylmercury Metabolism in an Exposed Amazon Population

Manifestações neurológicas em ribeirinhos de áreas expostas ao mercúrio na Amazônia brasileira

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