1996
DOI: 10.1002/eji.1830260717
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Mercury induces polyclonal B cell activation, autoantibody production and renal immune complex deposits in young (NZB × NZW)F1 hybrids

Abstract: It is well established that in susceptible mouse strains, chronic treatment with subtoxic doses of mercuric chloride (HgCl2) induces a systemic autoimmune disease, which is characterized by increased serum levels of IgG1 and IgE antibodies, by the production of anti-nucleolar antibodies and by the development of immune complex-mediated glomerulonephritis. Susceptibility to mercury is partly under the control of major histocompatibility complex genes. To study the susceptibility to mercury further, we investiga… Show more

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Cited by 53 publications
(71 citation statements)
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“…Total mouse serum IgE was determined by a sandwich ELISA assay as described previously [16]. We used a rat antimouse IgE monoclonal antibodies (MoAb), R35-72 (Pharmingen, San Diago, CA, USA) as the capture antibody and a biotinylated rat antimouse IgE MoAb, R35-92 (Pharmingen) as the detection antibody.…”
Section: Methodsmentioning
confidence: 99%
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“…Total mouse serum IgE was determined by a sandwich ELISA assay as described previously [16]. We used a rat antimouse IgE monoclonal antibodies (MoAb), R35-72 (Pharmingen, San Diago, CA, USA) as the capture antibody and a biotinylated rat antimouse IgE MoAb, R35-92 (Pharmingen) as the detection antibody.…”
Section: Methodsmentioning
confidence: 99%
“…The presence of IgG1 ANolA in the sera was determined by an indirect immunofluorescence method. Rat liver sections and/or HEp/2 cells grown as monolayers on slides were used as substrates and FITCconjugated goat antimouse IgG1 (Southern Biotechnology, Birmingham, AL, USA) as the detecting antibody [16]. The initial dilution for the sera was 1 : 50.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…Total mouse serum IgE antibodies were determined by a sandwich ELISA assay as described previously [10], using a rat anti-mouse IgE MoAb, R35-72 (Pharmingen, San Diego, CA) as a primary antibody and a biotinylated rat anti-mouse MoAb, R35-79 (Pharmingen) as a secondary antibody.…”
Section: Elisa For Mouse Ige Antibodymentioning
confidence: 99%
“…The presence of glomerular deposits of IgG1 antibodies was detected by direct immunofluorescence as described previously [10]. Briefly, The acetone-fixed kidney cryostat sections were incubated with serial dilutions of FITC-conjugated goat antimouse IgG1 antibodies (Southern Biothechnology, Birmingham, AL).…”
Section: Detection Of Renal Immune Complex Depositsmentioning
confidence: 99%