Mercury Materno-fetal Burden and Its Nutritional Impact

Hameed, Enas R. Abdel; Sherif, Lobna S.; Samie, Ola M. Abdel; Ahmed, Hanaa H.; Ahmed, Amira; Atta, H.M.; Waheed, Hisham; Fahmy, Reham F.

doi:10.3889/oamjms.2018.364

Cited by 3 publications

(3 citation statements)

References 40 publications

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“…A cross-sectional study that was conducted in the period from September 2016 to June 2017, 100 pregnant mothers and their newborns were recruited at the time of labour [10]. They were chosen randomly from those attending AL-Galaa Teaching Hospital as a research project, funded the by National Research Centre 10 th research plan, entitled “immunological profile in cord blood and growth assessment of the newborn about maternal exposure to environmental contaminant”.…”

Section: Methodsmentioning

confidence: 99%

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Heavy Metals Can either Aid or Oppose the Protective Function of the Placental Barrier

Hameed¹,

Shehata²,

Waheed³

et al. 2019

Open Access Maced J Med Sci

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BACKGROUND: In developing countries, toxic heavy metals are a threatening catastrophe to human health, particularly in the vulnerable group of pregnant mothers and their fetuses. Fortunately, the placenta can be a protective barrier to the fetuses. AIM: To explore the relationship between serum lead, cadmium and arsenic levels in pregnant mothers and their newborns, to address the placental barrier in this situation. METHODS: A cross-sectional study was conducted on 100 pregnant mothers at the time of labour and their newborns. Serum cadmium, lead, and arsenic levels were measured using the Inductively Coupled Plasma Mass Spectrometry. RESULTS: All the studied heavy metals concentrations showed a significant elevation in the maternal blood relative to the cord blood. There was a significant association between the maternal lead and both fetal lead and arsenic. Meanwhile, a negative but insignificant correlation was recorded between the maternal cadmium and each of the fetal cadmium, lead, and arsenic. CONCLUSION: The study findings indicated a weak relation between maternal and fetal blood heavy metals, except for the influence of maternal lead, so it can be assumed that the placental barriers are partially protective against those toxic pollutants, putting into consideration the influence of their different natures.

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Section: Methodsmentioning

confidence: 99%

“…These blood samples were for measuring the cadmium, lead, and arsenic levels in mothers and umbilical cord of fetus using inductively coupled plasma mass spectrometry, as shown in a previous study [10].…”

Section: Methodsmentioning

confidence: 99%

Heavy Metals Can either Aid or Oppose the Protective Function of the Placental Barrier

Hameed¹,

Shehata²,

Waheed³

et al. 2019

Open Access Maced J Med Sci

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“…Exposure to Hg can cause poor maternal health and decrease the placental and fetal growth (Harada, 1964;Mario et al, 2016). According to the previous studies, there are many adversities of Hg exposure for maternal and child health such as embryopathies, fetotoxicity, miscarriages, stillbirths, congenital craniofacial malformations including neural tube defects, brain damage and detrimental effects in the older age (Hameed et al, 2018). It also impacts on the fetal health by interrupting the migration and maturation of fetal nerves cells causing oxidative stress, cell membrane damage and protein synthesis impairment (Reus, Bando, Andrés, & Cascales, 2003).…”

Section: Achementioning

confidence: 99%

Effect of maternal blood heavy metal level on brain-derived neurotrophic factor and pregnancy outcomes among Myanmar migrants in Samut Sakhon province, Thailand

Zaw

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BACKGROUND: Lead, mercury, cadmium, and arsenic are the priority heavy metals of major public health concern in developing countries. Thailand is a newly industrialized country raising high human workloads of migrant workers form neighbored countries, mostly Myanmar. Exposure to these metals can cause cognitive impairment and depressive disorders through an effect on brain-derived neurotrophic factor (BDNF), which is an important biomarker of pregnancy. Pregnancy outcomes including preeclampsia, preterm birth and low birth weight are major burdens for maternal and child health. Although a number of prior studies have examined the effects of heavy metals on pregnancy, there are few studies focused on migrant population. The aim of this study was to examine the association between maternal blood heavy metals concentrations and BDNF levels and pregnancy outcomes among Myanmar migrants in Thailand. METHODOLOGY: This study was a birth cohort study conducted at the antenatal care clinic of the hospital from July 2018 to April 2019. A total of 119 pregnant Myanmar migrants carrying a single viable fetus of less than 14 weeks of gestation who had stayed within the industrial plant at least 3 months before were recruited in first trimester. The socio-demographic characteristics and health behaviors of the patients were assessed using a self-report questionnaire. Blood samples were collected in first trimester and third trimester. Maternal blood heavy metal (Pb, Hg, Cd, As) concentrations were measured using an inductively coupled plasma mass spectrometer, and plasma BDNF levels were measured using an enzyme-linked immunosorbent assay. Multivariate binary logistic regressions and multiple linear regressions were modeled to evaluate the associations between these factors. RESULTS: A total of 72 pregnant women were completed the study. Median (interquartile rank: IQR) concentrations were as follows: BDNF: (64.60 [15.60]/18.27 [23.40]) ?g/L, Pb: (27.40�[13.80]/19.90�[11.40]) ?g/L, Hg: (6.20 [5.60], 2.60�[2.00]) ?g/L, Cd: (0.91�[0.85]/1.06 [0.46]) ?g/L, and As: (4.00�[1.10]/3.40 [1.40]) ?g/L. We categorized the concentrations into high (? median) and low (<median) groups for binary logistic regressions. After adjusting for potential confounders, patients with a high blood As in first trimester had a 2.6-fold increased risk (aOR = 2.603, 95% CI: 1.178, 5.751) of low plasma BDNF in early pregnancy. Diastolic BP in third trimester was higher in every unit of increased third trimester blood Pb concentrations (? = 2.766, 95% CI: 0.026, 5.506). However, there were no significant associations between heavy metals and preeclampsia, preterm birth or low birth weight. CONCLUSIONS: The present findings demonstrate that pregnant women with higher blood As levels were more likely to have lower BDNF levels in early pregnancy. Pregnant women with high blood Pb have more risk of lower blood pressure in late pregnancy. Public health interventions to address Pb and As exposure should be promoted to improve the health of Myanmar migrants

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Leaf ethanolic extract of Etlingera hemesphaerica Blume alters mercuric chloride teratogenicity during the post-implantation period in Mus musculus

et al. 2019

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Mercury Materno-fetal Burden and Its Nutritional Impact

Cited by 3 publications

References 40 publications

Heavy Metals Can either Aid or Oppose the Protective Function of the Placental Barrier

Heavy Metals Can either Aid or Oppose the Protective Function of the Placental Barrier

Effect of maternal blood heavy metal level on brain-derived neurotrophic factor and pregnancy outcomes among Myanmar migrants in Samut Sakhon province, Thailand

Leaf ethanolic extract of Etlingera hemesphaerica Blume alters mercuric chloride teratogenicity during the post-implantation period in Mus musculus

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