Mercury Poisoning From Home Gold Ore Processing

Snodgrass, Wayne R.; Sullivan, John B.; Rumack, Barry H.; Hashimoto, Christine

doi:10.1001/jama.1981.03320170041027

Cited by 38 publications

(3 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…DPA is used in treatment of Wilson's disease [38,83] and heavy metal poisoning, since it is an effective chelator of copper [200][201][202], lead [203], gold [204], mercury [94,205], and zinc [201]. DPA was found to be beneficial in arsenic poisoning [28,31,206].…”

Section: 3-dimercaptopropane-1-sulphonic Acid (Dmps)mentioning

confidence: 99%

“…The first application of CaNa 2 EDTA for the treatment of lead poisoning in 1951 was a dramatic success and it soon became the preferred drug for the These two chelators are compared with the efficacy of others or newly synthesized chelating agents [184,188,[190][191][192][193][194] deferiprone (L1) Ferriprox oral iron, aluminum [36,258,[260][261][262] dimercaprol BAL in Oil, Sulfactin intramuscular arsenic, gold, lead, elemental and inorganic mercury (not organic!) [41,116] D-penicillamine Cuprimine, DePen, Metalcaptase, Trolovol oral copper (Wilson's disease), lead, mercury, zinc, gold [38,83,[200][201][202][203][204][205] meso-DMSA Chemet oral lead, mercury, arsenic, copper, antimony [136,138,[142][143][144][145][146][147][148][149][150][151][152] N-acetylcysteine* Acetadote, Mucomyst, Acetylcysteine oral intravenous mercury [99] N-acetyl-Dpenicillamine* N-Acetyl-D-Penicillamine oral mercury [94,209] Prussian blue Radiogardase (Prussian Blue), Antidotum Thallii-Heyl oral radioactive cesium, radioactive or non-radioactive thallium [40,41] tetrathiomolybdate -(orphan drug status) oral copper (Wilson's disease) <...>…”

Section: Polyaminopolycarboxylic Acidsmentioning

confidence: 99%

See 1 more Smart Citation

Chelators as Antidotes of Metal Toxicity: Therapeutic and Experimental Aspects

Blanuša¹,

Varnai²,

Piasek³

et al. 2005

CMC

240

150

View full text Add to dashboard Cite

The effects of chelating drugs used clinically as antidotes to metal toxicity are reviewed. Human exposure to a number of metals such as lead, cadmium, mercury, manganese, aluminum, iron, copper, thallium, arsenic, chromium, nickel and platinum may lead to toxic effects, which are different for each metal. Similarly the pharmacokinetic data, clinical use and adverse effects of most of the chelating drugs used in human metal poisoning are also different for each chelating drug. The chelating drugs with worldwide application are dimercaprol (BAL), succimer (meso-DMSA), unithiol (DMPS), D-penicillamine (DPA), N-acetyl-D-penicillamine (NAPA), calcium disodium ethylenediaminetetraacetate (CaNa(2)EDTA), calcium trisodium or zinc trisodium diethylenetriaminepentaacetate (CaNa(3)DTPA, ZnNa(3)DTPA), deferoxamine (DFO), deferiprone (L1), triethylenetetraamine (trientine), N-acetylcysteine (NAC), and Prussian blue (PB). Several new synthetic homologues and experimental chelating agents have been designed and tested in vivo for their metal binding effects. These include three groups of synthetic chelators, namely the polyaminopolycarboxylic acids (EDTA and DTPA), the derivatives of BAL (DMPS, DMSA and mono- and dialkylesters of DMSA) and the carbodithioates. Many factors have been shown to affect the efficacy of the chelation treatment in metal poisoning. Within this context it has been shown in experiments using young and adult animals that metal toxicity and chelation effects could be influenced by age. These findings may have a bearing in the design of new therapeutic chelation protocols for metal toxicity.

show abstract

Section: 3-dimercaptopropane-1-sulphonic Acid (Dmps)mentioning

confidence: 99%

Section: Polyaminopolycarboxylic Acidsmentioning

confidence: 99%

Chelators as Antidotes of Metal Toxicity: Therapeutic and Experimental Aspects

Blanuša¹,

Varnai²,

Piasek³

et al. 2005

CMC

240

150

View full text Add to dashboard Cite

show abstract

“…[72][73][74][75][76] Another scenario occurs when mercury compounds are heated, such as in the smelting of lead and or gold, typically in South America, or during paint removal. [77][78][79][80] These intoxication profiles are far more common than one might expect.…”

Section: Forms and Their Toxicitymentioning

confidence: 99%

Safety of Dental Amalgam

Osborne

Swift

2004

J Esthet Restor Dent

View full text Add to dashboard Cite

This Critical Appraisal is a departure from our usual format. Usually, contributors review several articles about a specific topic. Instead, we have asked Dr. Osborne to review several topics related to a specific issue, the safety of dental amalgam. Despite the increasing use of tooth‐colored restorative materials, amalgam remains a widely used and important part of the dentist's armamentarium. This article provides the practicing dentist with essential information regarding the safety of amalgam. We hope that you will find this helpful as you discuss safety issues with concerned patients.

show abstract