Mercury Poisoning Presenting With Hypertension: Report of 2 Cases

Jin, Yan; Pan, Yujie; Tang, Ziren; Song, Yuguo

doi:10.1016/j.amjmed.2019.03.050

Cited by 9 publications

(5 citation statements)

References 4 publications

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“…This condition may be associated with possible mercury exposure, since concentrations of this metal in the bloodstream are positively associated with blood pressure, hypertension, and other cardiovascular diseases. In addition, the exposure dose is an important factor in determining the effects on hypertension [ 75 , 76 , 77 ].…”

Section: Discussionmentioning

confidence: 99%

Sociobehavioral, Biological, and Health Characteristics of Riverside People in the Xingu Region, Pará, Brazil

Lucianelli

Pereira

Santos

et al. 2023

IJERPH

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This study aimed to evaluate the sociodemographic, behavioral, and biological profile and its relationship with the emergence of chronic non-communicable diseases in riverside populations in the Xingu region, Pará, Brazil. Characteristics related to health indicators and which risk factors are considered most important were analyzed. This is a cross-sectional, exploratory, and descriptive study. The sample consisted of riverside people of over 18 years of both sexes. The sample size (n = 86) was calculated with a confidence level of 95% and a sample error of 5%. The K-means clustering algorithm was adopted through an unsupervised method to divide the groups, and the values were expressed as a median. For continuous and categorical data, the Mann-Whitney and chi-square tests were used, respectively, and the significance level was set at p < 5%. The multi-layer perceptron algorithm was applied to classify the degree of importance of each variable. Based on this information, the sample was divided into two groups: the group with low or no education, with bad habits and worse health conditions, and the group with opposite characteristics. The risk factors considered for cardiovascular diseases and diabetes in the groups were low education (p < 0.001), sedentary lifestyle (p < 0.01), smoking, alcoholism, body mass index (p < 0.05), and waist–hip ratio, with values above the expected being observed in both groups. The factors considered important so as to be considered to have good health condition or not were the educational and social conditions of these communities, and one part of the riverside population was considered healthier than the other.

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Section: Discussionmentioning

confidence: 99%

Sociobehavioral, Biological, and Health Characteristics of Riverside People in the Xingu Region, Pará, Brazil

Lucianelli

Pereira

Santos

et al. 2023

IJERPH

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“…There are also some apparent systemic effects after intravenous injection, like pulmonic embolism and embolization of the heart [13,18,19]. Beyond that, Jin Yan et al [20] have documented two cases of secondary hypertension as the primary clinical manifestation of chronic contact mercury poisoning. And there are also a few cases of hemorrhagic colitis secondary to inhalation [21,22].…”

Section: Discussionmentioning

confidence: 99%

Intraorbital Mercury Removal by DSA Positioning and Route Marking: A 4-year Follow-up

Cai

Wei

Zhu

et al. 2021

Preprint

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Background: Mercury is a widely used heavy metal. Traumatic mercury residue often leads to contact dermatitis, granuloma, even chronic poisoning. Due to its unique physical and chemical properties, mercury beads can be difficult to retrieve, especially in the eyes. Most previous studies have focused only on the rigid orbital foreign bodies rather than the injuries related to liquid heavy metal and their extraction method.Methods: We reported a case of thermometer-related orbital injuries in a 4-year-old boy. To better locate, visualize and remove the mercury beads without complications, a Digital Subtraction Angiography (DSA)-guided, methylene blue marked access was taken, followed by further removal of scattered tiny mercury droplets with an adapted aspirator. Result: At least 0.7411g mercury was taken out during the surgery. After a four-year follow-up, the boy had no residual symptoms, with his urine mercury decreased gradually.Conclusion: Assessing the risk-return coefficient and making an appropriate therapeutic plan is an integral part of the pursuit of therapeutic progress. With the guidance of DSA and methylene blue, the suction of the reformative aspirator, we finally locate the mercury beads, maximize the removal of beads, reduce the length and depth of incisions, and keep the essential structures intact. Hence, we found it a valuable surgical skill on such occasions, worth sharing for future references.

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“…An expressive increase in plasma angiotensin II levels has been found in COVID-19-positive patients associated with lung injury [42]. Interestingly, mercury intoxication was related to increased blood levels of angiotensin II in both human and animal models [43,44]. Additionally, preclinical evidence has demonstrated that chronic mercury intoxication increases plasma ACE activity, thus producing more angiotensin II (Figure 2) [44].…”

Section: Covid-19 and Mercury Intoxication: Is There Any Adverse Syne...mentioning

confidence: 99%

Global Human Threat: The Potential Synergism between Mercury Intoxication and COVID-19

Arrifano

Augusto-Oliveira

Lopes-Araújo

et al. 2023

IJERPH

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The COVID-19 pandemic affected billions of people worldwide, and exposure to toxic metals has emerged as an important risk factor for COVID-19 severity. Mercury is currently ranked as the third toxic substance of global concern for human health, and its emissions to the atmosphere have increased globally. Both COVID-19 and mercury exposure present a high prevalence in similar regions: East and Southeast Asia, South America and Sub-Saharan Africa. Since both factors represent a multiorgan threat, a possible synergism could be exacerbating health injuries. Here, we discuss key aspects in mercury intoxication and SARS-CoV-2 infection, describing the similarities shared in clinical manifestations (especially neurological and cardiovascular outcomes), molecular mechanisms (with a hypothesis in the renin-angiotensin system) and genetic susceptibility (mainly by apolipoprotein E, paraoxonase 1 and glutathione family genes). Literature gaps on epidemiological data are also highlighted, considering the coincident prevalence. Furthermore, based on the most recent evidence, we justify and propose a case study of the vulnerable populations of the Brazilian Amazon. An understanding of the possible adverse synergism between these two factors is crucial and urgent for developing future strategies for reducing disparities between developed and underdeveloped/developing countries and the proper management of their vulnerable populations, particularly considering the long-term sequelae of COVID-19.

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Mercury Poisoning Presenting With Hypertension: Report of 2 Cases

Cited by 9 publications

References 4 publications

Sociobehavioral, Biological, and Health Characteristics of Riverside People in the Xingu Region, Pará, Brazil

Sociobehavioral, Biological, and Health Characteristics of Riverside People in the Xingu Region, Pará, Brazil

Intraorbital Mercury Removal by DSA Positioning and Route Marking: A 4-year Follow-up

Global Human Threat: The Potential Synergism between Mercury Intoxication and COVID-19

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