Mercury speciation in prenatal exposure in Slovenian and Croatian population – PHIME study

Trdin, Ajda; Tratnik, Janja Snoj; Mazej, Darja; Fajon, Vesna; Krsnik, Mladen; Osredkar, Joško; Prpić, Igor; Špirić, Zdravko; Petrović, Oleg; Marc, Janja; Neubauer, David; Kodrič, Jana; Kobal, Alfred B.; Barbone, Fabio; Falnoga, Ingrid; Horvat, Milena

doi:10.1016/j.envres.2019.108627

Cited by 12 publications

(7 citation statements)

References 46 publications

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“…This analysis of the training dataset found that the average blood MeHg/THg ratio was 0.75 (Table 2). This is similar to reported values: 0.69 to 0.85 from other analyses of NHANES data [28,30]; 0.63 from pregnant women in North Carolina [23]; 0.52 to 0.88 from populations in Europe [24,[31][32][33][34]; 0.86 from pregnant women in Suriname [35]; 0.72 to 0.93 from populations in Asia [22,29,36]; and 0.91 among newcomers to Canada [37]. Although the exact reason for the variation across populations is not known, it is possible this is related to differences in demographics or diet.…”

Section: Discussionsupporting

confidence: 91%

“…More recent studies have suggested that the percentage of blood THg comprising MeHg may be highly variable as well as lower than previously estimated [ 22 ], with some results only reaching 61–63% [ 23 ]. This has led to concern that measuring THg, instead of MeHg, may result in exposure misclassification in which MeHg exposure is overestimated, leading to inexact estimations of its health effects [ 24 , 25 ]. Thus, this poses a challenge for risk assessors, as it is unclear how to use the numerous studies that rely on measurements of blood THg in an exposure–response analysis for MeHg.…”

Section: Introductionmentioning

confidence: 99%

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Total Blood Mercury Predicts Methylmercury Exposure in Fish and Shellfish Consumers

Wells

Kopylev

Nachman

et al. 2021

Biol Trace Elem Res

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Many studies evaluating methylmercury (MeHg) toxicity rely on whole blood total mercury (THg) measurements to estimate MeHg exposure. However, whole blood THg includes other forms of mercury (Hg), such as inorganic Hg, which have different exposure sources and toxicological effects than MeHg. Therefore, estimating the whole blood MeHg/THg ratio is critical to predicting MeHg exposure and, subsequently, efforts to establish an exposure–response relationship for use in risk assessment. A large, representative dataset (National Health and Nutrition Examination Survey (NHANES) 2011–2016) was used to determine the whole blood MeHg/THg ratio among (a) self-reported fish and shellfish consumers, ≥ 15 years of age (the “full adult” population (N = 5268 training dataset; N = 2336 test dataset)) and (b) female fish and shellfish consumers, 15–44 years of age (the “women of reproductive age” population (N = 1285 training dataset; N = 560 test dataset)). Unadjusted and adjusted linear and spline models with direct measurements for both THg and MeHg were evaluated. The mean whole blood MeHg/THg ratio was 0.75 (95% confidence interval (CI): 0.74, 0.75). This ratio was significantly higher among those with higher THg concentrations. All models exhibited excellent fit (adjusted R2 from 0.957 to 0.982). Performance was slightly improved in spline versus linear models. For the full adult population and women of reproductive age, the unadjusted spline model predicted whole blood MeHg concentrations of 5.65 µg/L and 5.55 µg/L, respectively, when the THg concentration was 5.80 µg/L. These results suggest that whole blood THg is a good predictor of whole blood MeHg among fish and shellfish consumers.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Total Blood Mercury Predicts Methylmercury Exposure in Fish and Shellfish Consumers

Wells

Kopylev

Nachman

et al. 2021

Biol Trace Elem Res

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“…With regard to the levels of concern accepted as the current US EPA reference dose (RfD) for concentrations of total Hg of 6.4 µg/L and the equivalent for MeHg of 5.8 µg/L [24,28,58], we determined these Hg levels in blood in 10% of postpartum women and 31% of infants (cord blood) in the coastal area, compared to only <1% postpartum women and 3% infants in the continental area. The ratio of Hg concentrations in cord and maternal blood was reportedly higher for infants in Croatia and Slovenia [52,69]; however, our ratio results are lower than in Spain or other high-fish consuming countries, where >60% of Hg levels in infants exceeded the RfD value (see [70]). Studies conducted in Spain showed that 90% of pregnant women consumed seafood/fish ≥3 times per week, leading to high prenatal and early childhood exposure to Hg and MeHg measured in cord blood and hair samples of infants and preschool children [70,71].…”

Section: Hg In Maternal Hair and Blood Cord Blood And The Placentacontrasting

confidence: 62%

Mercury Exposure Assessment in Mother–Infant Pairs from Continental and Coastal Croatia

et al. 2020

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The main source of mercury (Hg) exposure in the general population is fish. Another possible source is dental amalgam. Here, we compare the levels of Hg and selenium (Se) in samples of maternal and fetal origin collected shortly after childbirth of healthy postpartum women in the coastal (n = 96) and continental (n = 185) areas of Croatia related to maternal seafood/fish consumption. We also evaluated Hg concentrations and maternal serum metallothionein (MT2) concentrations in relation to the number of dental amalgam fillings, and MT2A-5A/G (rs28366003) polymorphism. The levels of Hg and Se in maternal hair and blood/serum, placenta and cord blood/serum increased in relation to increasing fish consumption with the highest values in subjects from the coast. The concentrations of each element and between elements correlated across the matrices. Increasing amalgam number correlated linearly with increased Hg levels in maternal and cord serum and was not associated with serum MT2. No association of MT2A-5A/G polymorphism and Hg or Se levels were found. The results confirmed higher fish consumption in coastal vs. continental Croatia and increases of both Hg and Se related to fish consumption in all analyzed samples. Increased blood Hg reflected the predominant MeHg share from seafood, while increased serum Hg matched exposure from dental amalgams.

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“…HepaRG cells were exposed to mixtures of DEHP, DiNP, and BBzP phthalates, lead, and mercury. These were the most abundant pollutants in the RE-PRO PL (Polańska et al, 2011) and PHIME (Trdin et al, 2019) cohorts that studied environmental causation of neurodevelopmental disorders in neonates and children across Europe. The effective concentrations of the chemicals in vitro were estimated by extrapolation from human biomonitoring data through internal dosimetry modeling using the INTEGRA computational platform (Sarigiannis et al, 2016).…”

Section: The Exposome Meets the Toxome -Mechanistic Toxicology To Help Understand Exposome Patternsmentioning

confidence: 99%

The exposome – a new approach for risk assessment

Sillé

Karakitsios

Kleensang

et al. 2020

ALTEX

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Other 'omes existed even then, such as biome (collection of living things) and rhizome (system of roots), many of them based on the Greek suffix '-ome' -meaning, roughly, 'having the nature of.' But it was the glamorization of 'genome' by megabuck initiatives such as the Human Genome Project that really set the trend in motion, says Alexa McCray, a linguist and medical informatician at Harvard Medical School in Boston, Massachusetts. IntroductionClaiming a new 'ome has become fashionable in the post-human genome era. Monya Baker (2013), in her piece in Nature, claimed the number to be in the thousands. She wrote: "Botanist Hans Winkler had no idea what he was starting back in 1920, when he proposed the term 'genome' to refer to a set of chromosomes.

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Mercury speciation in prenatal exposure in Slovenian and Croatian population – PHIME study

Cited by 12 publications

References 46 publications

Total Blood Mercury Predicts Methylmercury Exposure in Fish and Shellfish Consumers

Total Blood Mercury Predicts Methylmercury Exposure in Fish and Shellfish Consumers

Mercury Exposure Assessment in Mother–Infant Pairs from Continental and Coastal Croatia

The exposome – a new approach for risk assessment

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