Merge of motion analysis, multibody dynamics and finite element method for the subject-specific analysis of cartilage loading patterns during gait: differences between rotation and moment-driven models of human knee joint

Abstract

Understanding joint loading is important when evaluating sports training methods, sports equipment design, preventive training regimens, post-op recovery procedures, or in osteoarthritis' etiology research. A number of methods have been introduced to estimate joint loads but they have been limited by the lack of accuracy in the joint models, including primarily the lack of patient-specific motion inputs in the models with sophisticated, fibril-reinforced material models. The method reported here records and applies patient-specific human motion for in-depth cartilage stress estimation. First, the motion B A. Kłodowski

New algorithm for simulation of proteoglycan loss and collagen degeneration in the knee joint: Data from the osteoarthritis initiative

“…Since only short‐term loading was applied, and because our main focus was on analyzing cartilage degeneration, only forces through the meniscal tissues (meniscal support forces) during loading were needed (not stresses/strains within the menisci). Therefore, meniscal tissues were considered as a transverse isotropic linear elastic material, similarly as in several previous knee joint modeling studies . In order to mimic the compression‐tension behavior in the meniscus, the axial and radial Young's moduli were designated as 20 MPa while the circumferential Young's modulus was 140 MPa.…”

“…In order to mimic the compression‐tension behavior in the meniscus, the axial and radial Young's moduli were designated as 20 MPa while the circumferential Young's modulus was 140 MPa. The in‐plane and out‐of‐plane Poisson's ratios were 0.3 and 0.2, respectively, and the shear modulus was set to 57.7 MPa …”

Maximum shear strain-based algorithm can predict proteoglycan loss in damaged articular cartilage

“…Both models were subjected to repetitive 2-MPa axial ramp load in unconfined compression with a rigid impermeable compression platen. The duration of the ramp loading was 0.1 s, which together with the load magnitude represents typical values of the gait loading response (Gilbert et al 2014;Kłodowski et al 2016). Such loading values have been used in a previous computational study as well .…”

A computational algorithm to simulate disorganization of collagen network in injured articular cartilage

“…Following an initial free-swelling step (to establish mechanical equilibrium and pre-strain in collagen network), a ramp load of 2 MPa for 0.1 s was applied on the cartilage surface in an unconfined compression geometry ( Figure 1A & B). The magnitude and duration of the load were selected to correspond to physiologically relevant loading, i.e., they can represent typical values during the loading response of the gait (Brand 2005;Yang et al 2010;Gilbert et al 2014;Tanska et al 2015;Kłodowski et al 2016). Similar values have also been used in other computational studies (Zhang et al 2015).…”

“…The loading protocol (a ramp load of 2 MPa in 0.1 s) was a simplification of a physiologically relevant loading such as that during the loading response of the gait cycle (Brand 2005;Yang et al 2010;Gilbert et al 2014;Tanska et al 2015;Korhonen et al 2015;Kłodowski et al 2016).…”