Merging colloidal nanoplasmonics and surface plasmon resonance spectroscopy for enhanced profiling of multiple myeloma-derived exosomes

Noto, G.; Bugatti, Antonella; Zendrini, Andrea; Mazzoldi, Elena Laura; Montanelli, Alessandro; Caimi, Luigi; Rusnati, Marco; Ricotta, Doris; Bergese, Paolo

doi:10.1016/j.bios.2015.09.061

Cited by 73 publications

(57 citation statements)

References 33 publications

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“…Thus, microfluidic technologies for exosome analysis are more likely to be commercialized in the academic research market first, with early examples seen in the adoption of commercially available microfluidic-based instruments for exosome analysis. 129–133 …”

Section: Discussionmentioning

confidence: 99%

Microfluidics for exosome isolation and analysis: enabling liquid biopsy for personalized medicine

2017

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Exosomes, the smallest sized extracellular vesicles (30 ~ 150 nm) packaged with lipids, proteins, functional messenger RNAs and microRNAs, and double-stranded DNA from their cells of origin, have emerged as key players in intercellular communication. Their presence in bodily fluids, where they protect their cargo from degradation, makes them attractive candidates for clinical application as innovative diagnostic and therapeutic tools. But routine isolation and analysis of high purity exosomes in clinical settings is challenging, with conventional methods facing a number of drawbacks including low yield and/or purity, long processing times, high cost, and difficulties in standardization. Here we review a promising solution, microfluidic-based technologies that have incorporated a host of separation and sensing capabilities for exosome isolation, detection, and analysis, with emphasis on point of care and clinical applications. These new capabilities promise to advance fundamental research while paving the way toward routine exosome-based liquid biopsy for personalized medicine.

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Section: Discussionmentioning

confidence: 99%

Microfluidics for exosome isolation and analysis: enabling liquid biopsy for personalized medicine

2017

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“…SPR is very sensitive to the variations of refractive index (RI) and particularly useful for biosensing, owing to the label-free and real-time detection [2]. Several SPR-based techniques such as SPR enhanced imaging and SPR spectroscopy have been developed [3,4]. Recently, SPR on periodic aperture arrays has garnered a great deal of research interest associated with an extraordinary optical transmission (EOT) phenomenon since first being reported by Ebbesen in 1998 [5].…”

Section: Introductionmentioning

confidence: 99%

Significantly enhanced sensitivity using a gold aperture arrays-dielectric hybrid structure in optical fiber sensor

Xiao

Pan

et al. 2019

J. Phys. Commun.

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In this paper, we propose a novel gold aperture arrays-dielectric hybrid structure in optical fiber sensor (OFS) based on the extraordinary optical transmission (EOT) property to explore the possibility of increasing its sensitivity. Numerical investigations show that the match between effective indices of the fundamental core mode and surface plasmon polariton (SPP) mode of gold aperture arraysdielectric interface affects the sensitivity enhancement by using mode analysis approach. The essential parameters of the hybrid structure including the gold film thickness and dielectric refractive index (RI) as well as its thickness, which affect the EOT, are discussed and optimized. An average sensitivity of 180±7 nm/RIU in the sensing range 1.30-1.45 with high linearity is obtained. It is demonstrated that a significant sensitivity enhancement with a dielectric layer (its RI is 1.90 and its thickness is 50 nm) up to 105 arbitrary units (∼140%) is clearly observed more than that without a dielectric layer. The averaged figure of merit (FOM) of the proposed OFS is calculated to be 12.5 RIU −1 . Our findings indicate that this proposed hybrid structure may offer great potential in designing and optimizing a high-performance OFS.

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“…SPR is highly sensitive to variations in the refractive indexes or optical absorption and particularly useful to biosensing due to the label-free and real-time detection of the kinetics of biological processes [2,3]. Several SPR-based techniques such as SPRenhanced fluorescence, SPR imaging, and SPR spectroscopy have been developed [4][5][6] and there has been significant technical progress pertaining to the light modulation methods, sensing elements, and configurations. The conventional SPR sensing structure is based on Kretschmann and Reather's attenuated total reflection (ATR) [7].…”

Section: Introductionmentioning

confidence: 99%

Mid-infrared surface plasmon resonance sensor based on photonic crystal fibers

Liu

Yang

Lu³

et al. 2017

Opt. Express

257

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A surface plasmon resonance (SPR) sensor with two open-ring channels based on a photonic crystal fiber (PCF) is described. The sensor is designed to detect low refractive indexes between 1.23 and 1.29 with the operation wavelength in mid-infrared region between 2550 nm and 2900 nm. The coupling characteristics and sensing properties are numerically analyzed by the finite element method. The average spectral sensitivity is 5500 nm/RIU and a maximum resolution of 7.69 × 10 RIU can be obtained. Our analysis shows that the PCF-SPR sensor is suitable for mid-infrared detection.

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Merging colloidal nanoplasmonics and surface plasmon resonance spectroscopy for enhanced profiling of multiple myeloma-derived exosomes

Cited by 73 publications

References 33 publications

Microfluidics for exosome isolation and analysis: enabling liquid biopsy for personalized medicine

Microfluidics for exosome isolation and analysis: enabling liquid biopsy for personalized medicine

Significantly enhanced sensitivity using a gold aperture arrays-dielectric hybrid structure in optical fiber sensor

Mid-infrared surface plasmon resonance sensor based on photonic crystal fibers

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