2023
DOI: 10.1002/adsc.202300305
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Merging Continuous Flow Technology, Photochemistry and Biocatalysis to Streamline Steroid Synthesis

Abstract: Since their structural elucidation in 1935, the introduction and substitution of functional groups and the modification of the steroidal scaffolds have been a fertile ground of research for synthetic and medicinal chemists. The discovery of steroids with hormonal and pharmacological activity has stimulated tremendous efforts to the development of highly selective and efficient synthetic procedures. Despite the progress made, steroid chemistry remains challenging and the preparation of steroidal compounds of ph… Show more

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Cited by 8 publications
(2 citation statements)
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“…phenol deprotonation, potassium trimethylsilanoxide (12) was loaded into a syringe w (11), while the alkyl bromide (13) was loaded into a second syringe to be pumped in reaction loop. The final step was the deprotection of the compound (14) with TFA. A could not be carried out in DMF, another step was necessary to change the solven The first total synthesis was reported in 2009 by Ullah and Arafeh using a traditional batch approach [33].…”
Section: Synthesis Of Aplysaminesmentioning
confidence: 99%
See 1 more Smart Citation
“…phenol deprotonation, potassium trimethylsilanoxide (12) was loaded into a syringe w (11), while the alkyl bromide (13) was loaded into a second syringe to be pumped in reaction loop. The final step was the deprotection of the compound (14) with TFA. A could not be carried out in DMF, another step was necessary to change the solven The first total synthesis was reported in 2009 by Ullah and Arafeh using a traditional batch approach [33].…”
Section: Synthesis Of Aplysaminesmentioning
confidence: 99%
“…It is also possible to carry out an in situ analysis of the reaction outcome by installing analytical techniques (IR and NMR spectroscopy, and MS) or even subsequent purification systems (e.g., flash chromatography and HPLC). Furthermore, novel synthetic techniques such as photochemistry, electrochemistry, or artificial intelligence can be implemented, which overcome some limitations found in the batch mode [14]. Automated systems have also been reported in continuous flow chemistry.…”
Section: Introductionmentioning
confidence: 99%