Merging konjac glucomannan with other copolymeric hydrogels as a cutting-edge liquid raft system for dual delivery of etoricoxib and famotidine

Abstract

This study aimed to formulate and evaluate a floating raft system for the co-delivery of etoricoxib (ETO) and famotidine (FAM) using a combination of glucomannan with natural/semi-synthetic polysaccharides. Formulation variables affect gelation lag time (GLT), floating lag time (FLT), and release percentage of drugs after 1–8 h, Stability, and viscosity parameters were evaluated. In vivo X-ray studies, followed by the pharmacokinetic study, were performed on human volunteers. Formulations exhibited pseudoplastic behavior for ease of swallowing. The optimum raft system (ORS) comprised 1% Na alginate, 0.1% Low Methoxyl (LM) pectin, 0.8% Konjac glucomannan (KGL), 1% Precirol, and 1% CaCO 3 . ORS exhibited rapid GLT and FLT (around 42 and 8 sec respectively) in 0.1 N HCl as well as controlled release of ETO (15% in 1 h and 82% in 8 h) and FAM (29% in 1 h and 85% in 8 h). Formulation stability with the absence of any drug-excipient interactions was observed. The X-ray imaging showed a promising buoyancy ability for approximately 8 h. Compared with marketed products, ORS showed superior relative bioavailability for both drugs. These findings revealed the successful preparation of a promising raft system with improved dual drug delivery.

Development of canagliflozin nanocrystals sublingual tablets in the presence of sodium caprate permeability enhancer: formulation optimization, characterization, in-vitro , in silico , and in-vivo study

“…The calculation of the compressibility index (Carr’s index) and Hausner’s ratio is a quick and simple approach for predicting the flowability and the compressibility of powders (Convention USP, 2012 ; Shoman et al., 2023 ). They are affected by bulk and tapped density, which is connected to the powder’s moisture content and cohesiveness (Council of Europe, 2019 ).…”

“…Then, the cylindrical graduation was tapped until uniformity of the volume was achieved. The tapped density (t) was then calculated using the measured powder’s final volume (Vf): Carr’s index and Hausner’s ratio were calculated using the following formulas (Salah et al., 2018 ; Shoman et al., 2023 ). A Carr’s index of <15 and a Hausner’s ratio of <1.8, indicate good compressibility as per the European Pharmacopeia (Council of Europe, 2017 ).…”

“…The dissolving solution was McIlvaine buffer (citric acid/phosphate buffer, pH 4). At set intervals (5, 10, 15, 30, 60, and 360 min), aliquots were taken, filtered, and HPLC analyses were performed to look for CFZ at a maximum of 240 nm (Shoman et al., 2023 ). An equivalent volume of the release media was used to replace the samples that were taken out.…”

Formulation, optimization and evaluation of ocular gel containing nebivolol Hcl-loaded ultradeformable spanlastics nanovesicles: In vitro and in vivo studies

“…Using Zetasizer (ZEN 3600, Malvern Instruments Limited, UK), the vesicle size of various formulae, before and after filtration was determined. Using the following equation ( Shoman et al, 2023 ):…”

Simultaneous Delivery of Curcumin and Resveratrol via In Situ Gelling, Raft-Forming, Gastroretentive Formulations

“…Raft-forming formulations have been reported to successfully deliver various drugs and herbal medicines. For example, etoricoxib-famotidine was combined and was beneficial for the treatment of pain and preventing ulcers in long-term use [32]. Raft-forming formulations of several herbal medicines also supported the effectiveness of this system such as curcumin [33,34] chebulinic acid [35], Aloe vera [36], and quercetin [37].…”