Meriandra dianthera Aqueous Extract and Its Fraction Prevents Blood Coagulation by Specifically Inhibiting the Intrinsic Coagulation Pathway: An in vitro Study

Kiflemariam, Filmon Kiflezghi; Tewelde, Abiel Ghebrehiwet; Hamid, Ali Mahmud; Beshir, Bilal Mussa; Solomon, Samrawit Negasi; Eman, Tesfu Gonets; Abraha, Daniel Mebrahtu; Kahsu, Russom; Issac, John; Kaushik, Jeevan Jyoti

doi:10.2147/jep.s362258

Cited by 5 publications

(4 citation statements)

References 11 publications

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“…17 Previous studies also reported anticoagulant and antiplatelet effects of different plant extracts. 14,17,18,23,24,25,26 Similar to the present results, the EtOAc fractions of Canna species were proved to exhibit the most potent antiaggregatory and anticoagulant activity among fractions. 17,18 Further investigation led to the identification of antithrombotic compounds from the EtOAc fraction of Canna plants.…”

Section: Discussionsupporting

confidence: 83%

“…14,17,24 The extracts from leaves of Meriandra dianthera also expressed anticoagulant effects on APTT and PT. 23 The potential antiplatelet and anticoagulant activity of the aerial PO suggests that PO is a promissory candidate for the development of alternative therapies or supplementary products to prevent and treat CVDs. The detected antithrombotic effect of the PO aerial part could be explained by the abundant phytochemicals present in the plant, including flavonoids, terpenoids, carotenoids, alkaloids, polysaccharides, sterols, fatty acids, proteins, vitamins, and minerals.…”

Section: Discussionmentioning

confidence: 99%

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Potential Inhibitory Effects on Human Platelet Aggregation and blood Coagulation of the Aerial Part of Portulaca oleracea L

2024

TJNPR

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Potential Inhibitory Effects on Human Platelet Aggregation and blood Coagulation of the Aerial Part of Portulaca oleracea L

2024

TJNPR

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“…APTT is an essential metric for assessing the internal coagulation pathway. 44 An increased APTT signifies abnormalities in coagulation factors and disruptions in internal coagulation. In our study, Cox multifactorial analysis revealed that an increased APTT is an independent risk factor for 28-day mortality in patients with SA-AKI.…”

Section: Discussionmentioning

confidence: 99%

Elevated Activated Partial Thromboplastin Time as a Predictor of 28-Day Mortality in Sepsis-Associated Acute Kidney Injury: A Retrospective Cohort Analysis

Lin,

Wang,

Cai

et al. 2024

IJGM

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To address the critical mortality rates among sepsis-associated acute kidney injury (SA-AKI) patients, early prognosis is vital. This study investigates the relationship between coagulation indices and the 28-day mortality rate in patients with SA-AKI. Patients and Methods: This study was a retrospective cohort analysis including patients with SA-AKI admitted to the First Hospital of Fujian Medical University as a training cohort (n = 119) and patients admitted to the Third People's Hospital of Fujian University of Traditional Chinese Medicine as a validation cohort (n = 51). We examined the relationship between coagulation indices and 28-day mortality in SA-AKI, the cumulative mortality at different activated partial thromboplastin time (APTT) levels, and the nonlinear relationship between APTT and 28-day mortality. Receiver operating characteristic curves were plotted, and the area under the curve was calculated to assess the predictive power of APTT. Finally, subgroup analyses were performed to assess the robustness of the association. Results: Overall, 119 participants with a mean±standard deviation age of 70.47±15.20 years were included in the training cohort: 54 died, 65 survived. According to univariate and multivariate COX regression analyses, APACHE II score, CRP level, Lac level, and APTT level were independent risk factors for 28-day adverse prognosis. After controlling for some variables, an elevated baseline APTT (≥ 37.7 s) was associated with an elevated risk of 28-day mortality (HR, 1.017; 95% CI, 1.001-1.032), and Kaplan-Meier analyses further confirmed the increased mortality in the group with a higher APTT. The same results were shown when the validation cohort was analyzed (HR, 1.024; 95% CI, 0.958-1.096). Subgroup analyses showed the stability of the association between APTT and poor prognosis in SA-AKI. Conclusion:In essence, APTT elevation is synonymous with increased 28-day mortality rates, indicating a poor prognosis in SA-AKI scenarios.

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“…Time of coagulation was calculated [23]. The PT assay gives a clear picture of the extrinsic pathway factors [39].…”

Section: In Vitro Blood Coagulation Studymentioning

confidence: 99%

Synthesis, chemical characterization, and biological investigation of naturally isolated hesperidin and its metal complexes

A.M. Abdelgawad,

A.I. El Bassossy,

A. Ahmed

2024

Bull. Chem. Soc. Eth.

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This study was conducted to investigate the ability of hesperidin (HES) to form metal-complexes (HES-M) by chelation with transition metals such iron(III), copper(II), zinc(II), and silver(I), in addition to screen the antioxidant activity (DPPH free radical scavenging and phosphomolybdenum reduction potential methods PRP), anti-Alzheimer activity [(acetylcholinesterase (AChE)] inhibition assay) and coagulant activity (prothrombin time PT assay). The results indicated that HES could form a 1:1 complex with the studied metals in methanolic solution. The complex has been synthesized and characterized by physicochemical methods. Complexing of hesperidin with metals leads to increase in the antioxidant activity by 15.4-33%. Also, the total antioxidant capacities of HES-M complexes were increased by 13.8-251%. Cu-complex revealed the most increasing antioxidant activity by 33% for DPPH scavenging activity and 251% for PRP activity. The inhibition capacity of the HES, as well as of the HES-M complexes on the enzyme AChE, was revealed that only HES-Zn complex has higher anti-Alzheimer activity (IC50 1.18 mg/mL). HES and HES-M complexes led to accelerate the clotting time by 28.9-67.3%, where HES-Zn complex was the most accelerating clotting time by 67.3%. The high increase in total antioxidant activity of hesperidin after chelating with copper (251%) opens the door for further research. KEY WORDS: Hesperidin, Metal ions, Complexation, Antioxidant, Anti-Alzheimer, Coagulant activity Bull. Chem. Soc. Ethiop. 2024, 38(2), 385-395. DOI: https://dx.doi.org/10.4314/bcse.v38i2.8

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Meriandra dianthera Aqueous Extract and Its Fraction Prevents Blood Coagulation by Specifically Inhibiting the Intrinsic Coagulation Pathway: An in vitro Study

Cited by 5 publications

References 11 publications

Potential Inhibitory Effects on Human Platelet Aggregation and blood Coagulation of the Aerial Part of Portulaca oleracea L

Potential Inhibitory Effects on Human Platelet Aggregation and blood Coagulation of the Aerial Part of Portulaca oleracea L

Elevated Activated Partial Thromboplastin Time as a Predictor of 28-Day Mortality in Sepsis-Associated Acute Kidney Injury: A Retrospective Cohort Analysis

Synthesis, chemical characterization, and biological investigation of naturally isolated hesperidin and its metal complexes

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