Merit of Ginseng in the Treatment of Heart Failure in Type 1-Like Diabetic Rats

Tsai, Chin‐Feng; Chan, Paul; Chen, Li‐Jen; Chang, Che-Jung; Liu, Zhongmin; Lin, Jia Wei

doi:10.1155/2014/484161

Cited by 20 publications

(12 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Activation of PPARδ by an agonist may improve phenylephrine-induced hypertrophy in cardiomyocytes [ 39 ]. Furthermore, ginseng has been demonstrated to improve heart function via PPARδ in diabetic rats [ 21 ]. In the present study, PPARδ is substantially reduced in the hearts of diabetic rats.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Ginsenoside Rh2 Improves Cardiac Fibrosis via PPARδ–STAT3 Signaling in Type 1-Like Diabetic Rats

Hsu

Niu

et al. 2017

IJMS

View full text Add to dashboard Cite

Ginsenoside Rh2 (Rh2) is an active principal ingredient contained in ginseng (Panax ginseng Meyer), a medicinal herb used to enhance health worldwide. The present study is designed to investigate the effect of Rh2 on myocardial fibrosis in diabetic rats. In a streptozotocin-induced model of type-1 diabetic rats (STZ-diabetic rats), the increased fasting blood glucose levels and heart weight/body weight (HW/BW) ratio were substantially alleviated by Rh2. Moreover, Rh2 improved cardiac performance in STZ-diabetic rats. Histological results from Masson staining showed that Rh2 attenuated cardiac fibrosis in STZ-diabetic rats. The effects of Rh2 were reversed by GSK0660 at a dose sufficient to inhibit peroxisome proliferator-activated receptor δ (PPARδ) in STZ-diabetic rats. The role of PPARδ was subsequently investigated in vitro. Rh2 restored the decreased PPARδ expression level in high glucose-cultured cardiomyocytes. Moreover, increased protein levels of fibrotic signals, including signal transducer and activator of transcription 3 (STAT3), connective tissue growth factor (CCN2) and fibronectin, were reduced by Rh2 in high glucose-cultured cardiomyocytes. These effects of Rh2 were reversed by GSK0660 or siRNA specific for PPARδ Taken together, PPARδ activation may inhibit STAT3 activation to reduce CCN2 and fibronectin expression in diabetic rats with cardiac fibrosis. Moreover, Rh2 improves cardiac function and fibrosis by increasing PPARδ signaling. Therefore, Rh2 is suitable to develop as an alternative remedy for cardiac fibrosis.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Rh2 may also attenuate hyperglycemia in diabetic rats [ 20 ]. Moreover, ginseng has been documented to improve heart function via PPARδ in diabetic rats [ 21 ]. Recently, the activation of PPARδ has been demonstrated to attenuate STAT3 expression [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Ginsenoside Rh2 Improves Cardiac Fibrosis via PPARδ–STAT3 Signaling in Type 1-Like Diabetic Rats

Hsu

Niu

et al. 2017

IJMS

View full text Add to dashboard Cite

show abstract

“…P. ginseng also increased expression of peroxisome proliferator-activated receptor (PPAR) δ in the hearts of DM rats. Therefore, Tsai and colleagues suggested that P. ginseng could improve heart failure by increasing PPAR δ activity in DM rats [6]. In a rat model with ligation of coronary arteries, P. ginseng reversed cardiac hypertrophy, myocardial remodeling, and heart failure by inhibition of calcineurin activation [7].…”

Section: Introductionmentioning

confidence: 99%

Ginsenoside Re Improves Isoproterenol-Induced Myocardial Fibrosis and Heart Failure in Rats

Wang

et al. 2019

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Objective. Panax ginseng is used widely for treatment of cardiovascular disorders in China. Ginsenoside Re is the main chemical component of P. ginseng. We aimed to investigate the protective effect of ginsenoside Re on isoproterenol-induced myocardial fibrosis and heart failure in rats. Methods. A model of myocardial fibrosis and heart failure was established by once-daily subcutaneous injection of isoproterenol (5 mg/kg/day) to rats for 7 days. Simultaneously, rats were orally administrated ginsenoside Re (5 or 20 mg/kg) or vehicle daily for 4 weeks. Results. Isoproterenol enhanced the heart weight, myocardial fibrosis, and hydroxyproline content in rat hearts. Ginsenoside Re inhibited (at least in part) the isoproterenol-induced increase in heart weight, myocardial fibrosis, and hydroxyproline content. Compared with the isoproterenol group, treatment with ginsenoside Re ameliorated changes in left ventricular systolic pressure, left ventricular end diastolic pressure, and the positive and negative maximal values of the first derivative of left ventricular pressure. Ginsenoside Re administration also resulted in decreased expression of transforming growth factor (TGF)-β1 in serum and decreased expression of Smad3 and collagen I in heart tissue. Conclusion. Ginsenoside Re can improve isoproterenol-induced myocardial fibrosis and heart failure by regulation of the TGF-β1/Smad3 pathway.

show abstract

“…Ginseng is useful to enhance cardiac contractility in animals [ 27 ]. Recently, ginseng has been garnering increasing interest in its effects on the cardiovascular system and in the treatment of heart failure [ 28 ]. Ginsenosides, the effective component of ginseng, regulates cardiovascular function on cardiomyocyte contraction, which may be mediated in part through increased NO production [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Chinese Veterinary Medicine B307 Promotes Cardiac Performance and Skeletal Muscle Contraction via Enhancing Intracellular Calcium Levels and Neural Electrical Activity in Animal and Cell Models

Lien

Hsu

et al. 2020

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

The study mainly investigated the effects of Chinese veterinary medicine B307 in cardiac and motor functions in animal models of pigeons and mice. Related cellular mechanisms were also studied in the neuroblastoma cell model of SH-SY5Y. Cardiac functions of pigeons and mice were examined by using moorFLPI Laser color Doppler imager and M-mode echocardiography, and motor functions were examined by using muscle electrical stimulation and force recording in the isolated breast muscle. Intracellular calcium levels and electrical activity of SH-SY5Y cells were examined by using Fura 2-AM fluorescence and MED64 system separately. Our results in vivo found that those pigeons under oral B307 treatment obviously enhanced subcutaneous microcirculation and contractile force and prolonged fatigue time in their breast muscles. Those mice under oral B307 treatment obviously elevated ejection fraction and cardiac output in their hearts. Our results in vitro showed that those SH-SY5Y cells under B307 treatment obviously increased intracellular calcium mobilization and electrical activities. These results revealed that improvement of cardiac and motor functions under B307 treatments may be caused by increasing electrical activities and intracellular calcium levels in neuromuscular cells and a similar mechanism may also occur in muscle cells. Thus, we suggested that B307 can be a functional Chinese veterinary medicine for flying pigeons.

show abstract

Merit of Ginseng in the Treatment of Heart Failure in Type 1-Like Diabetic Rats

Cited by 20 publications

References 53 publications

Ginsenoside Rh2 Improves Cardiac Fibrosis via PPARδ–STAT3 Signaling in Type 1-Like Diabetic Rats

Ginsenoside Rh2 Improves Cardiac Fibrosis via PPARδ–STAT3 Signaling in Type 1-Like Diabetic Rats

Ginsenoside Re Improves Isoproterenol-Induced Myocardial Fibrosis and Heart Failure in Rats

Chinese Veterinary Medicine B307 Promotes Cardiac Performance and Skeletal Muscle Contraction via Enhancing Intracellular Calcium Levels and Neural Electrical Activity in Animal and Cell Models

Contact Info

Product

Resources

About