Merit of quinacrine in the decrease of ingested sulfite-induced toxic action in rat brain

Kencebay, Ceren; Derın, Narin; Özsoy, Özlem; Kipmen-Korgun, Dijle; Tanrıöver, Gamze; Ozturk, Nihal; Basaranlar, Goksun; Yargicoglu-Akkiraz, Piraye; Sözen, Berna; Ağar, Ayşel

doi:10.1016/j.fct.2012.11.015

Cited by 22 publications

(13 citation statements)

References 71 publications

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“…Five sulfite salts including sodium metabisulfite (Na 2 S 2 O 5 ), potassium metabisulfite (K 2 S 2 O 5 ), sodium bisulfite (NaHSO 3 ), potassium sulfite (K 2 SO 3 ), and sodium sulfite (Na 2 SO 3 ) are commonly used as antioxidants in food and pharmaceutical preparations (5,6). Generally Exposure to sulfite-containing compounds induced adverse clinical effects in sensitive individuals, ranging from dermatitis, urticaria, hypotension and diarrhoea to life-threatening anaphylactic and asthmatic reactions.…”

Section: Page 3 Of 27mentioning

confidence: 99%

Demonstrating adverse effects of a common food additive (sodium sulfite) on biochemical, cytological and histopathological parameters in tissues of albino Wister rats

Mahmoud

Hassan

et al. 2015

European Journal of Integrative Medicine

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Section: Page 3 Of 27mentioning

confidence: 99%

Demonstrating adverse effects of a common food additive (sodium sulfite) on biochemical, cytological and histopathological parameters in tissues of albino Wister rats

Mahmoud

Hassan

et al. 2015

European Journal of Integrative Medicine

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“…Rats were randomly divided into four experimental groups as follows: control (Control); sulphite-treated (Sulphite); 6-OHDAinjected (6-OHDA), and sulphite-treated + 6-OHDA injected (6-OHDA+Sulphite). Sulphite in the form of sodium metabisulphite (Na 2 S 2 O 5 ) (100 mg/kg/day nominal dose) was given to the treatment groups for 45 days by gavage [38]. In order to eliminate the effects of daily gavage; other groups received similar volume of water alone.…”

Section: Experimental Designmentioning

confidence: 99%

The Effect of Sodium Metabisulphite on Locomotor Activity in the Experimental Model of Parkinson’s Disease: The Role of Cyclooxygenase

Parlak¹,

Özkan²,

Özsoy³

et al. 2018

J Nutr Food Sci

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Parkinson's disease (PD) is characterized by a progressive and selective loss of dopaminergic neurons in substantia nigra (SN). PD is the second most common neurodegenerative disease after Alzheimer disease. Although the exact cause of disease is not known, oxidative stress, neuroinflammation, mitochondrial dysfunction and microglial activation are observed in PD. The aim of this study was to investigate the mechanism underlying possible toxic effects of sulphite on the experimental model of PD. Male Wistar rats were assigned into one of four groups Control (Control), Sulphitetreated (Sulphite), 6-hydroxydopamine (6-OHDA)-injected (6-OHDA) and sulphite-treated and 6-OHDA-injected (6-OHDA+Sulphite). Sodium metabisulphite was administered at a dose of 100 mg/kg/day for 45 days by gavage. Experimental PD was created stereotactically via the unilateral infusion of 6-OHDA into the medial forebrain bundle (MFB). 6-OHDA-injected rats exhibited reduced locomotor activity compared to control. A significant increase in catalepsy was found in the 6-OHDA-injected group as compared to the the control group. Plasma levels of S-sulfonate increased in Sulphite and 6-OHDA+Sulphite groups as compared to their respective controls. Cyclooxygenase (COX) enzyme activity, prostaglandin E2 (PGE2) and nuclear factor kappa B (NF-κB) levels increased in the 6-OHDA group as compared to control. The tyrosine hydroxylase (TH)-positive immunostainingdecreased significantly in the 6-OHDA-injected group where the sulphite and control groups had almost the same immunoreaction for the dopaminergic neurons. In conclusion, sulphite is not a potentially aggravating factor for the activity of COX and the levels of PGE2 or NF-κB in a 6-OHDA-induced experimental model of Parkinson's disease.

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“…People may suffer from asthmatic and allergic reactions if they ingested foods containing large amounts of sulfites, especially in free (or reversibly bound) sulfite form (Moseholm, Taudorf, & Frøsig, ; Reno, Brooks, & Ameredes, ). Besides, long‐term exposure to sulfites can cause neurotoxicity and even damage to the reproductive system (Kencebay et al, ; Marshall, Reist, Jenner, & Halliwell, ). Many countries and international organizations have laid strict restrictions on the contents of sulfite in different foodstuffs.…”

Section: Introductionmentioning

confidence: 99%

Establishing a method of HPLC involving precolumn derivatization by 2,2′‐dithiobis (5‐nitropyridine) to determine the sulfites in shrimps in comparison with ion chromatography

Yang

Zhou

Yang

et al. 2019

Food Science & Nutrition

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Although sulfites are widely used in shrimp processing, the contents of residual sulfite need to be strictly controlled due to their potential toxicity. In this paper, a novel method was developed for determination of the free and total sulfites in shrimps. Major procedures of the method includes separation of free and total sulfites with ultrasound‐assisted extraction and pH adjustment for 20 min, then a precolumn derivatization was conducted by 2,2′‐Dithiobis (5‐nitropyridine) and verified by LC‐MS, and finally HPLC coupled with an ultraviolet (UV) detector was carried out. Results indicated that the UV absorption wavelength shifted from 213 (sulfites) to 320 nm (new disulfide compounds), significantly reducing the interference of natural occurring compounds and solvents in the matrix. The standard curves exhibited a good linear range of 3.2–51.2 mg/L ( R 2 = 0.9996). The limit of detection (LOD) and limit of quantification (LOQ) were 0.3 and 1.0 mg/L, respectively. The contents of free and total sulfite in frozen shrimps were 26.58 ± 0.48 and 31.44 ± 0.83 mg/kg calculated by SO 2 , respectively. These were similar ( p > 0.05) to the data obtained by the method of ion chromatography. In conclusion, the new developed method has been proved to be a reliable and economic method for effective determination of free and total sulfites in the shrimps, and the method could be expanded in determination of the sulfites in other food products.

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Merit of quinacrine in the decrease of ingested sulfite-induced toxic action in rat brain

Cited by 22 publications

References 71 publications

Demonstrating adverse effects of a common food additive (sodium sulfite) on biochemical, cytological and histopathological parameters in tissues of albino Wister rats

Demonstrating adverse effects of a common food additive (sodium sulfite) on biochemical, cytological and histopathological parameters in tissues of albino Wister rats

The Effect of Sodium Metabisulphite on Locomotor Activity in the Experimental Model of Parkinson’s Disease: The Role of Cyclooxygenase

Establishing a method of HPLC involving precolumn derivatization by 2,2′‐dithiobis (5‐nitropyridine) to determine the sulfites in shrimps in comparison with ion chromatography

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