Merits and Demerits of Operative Procedure to the Trachea in Patients with Differentiated Thyroid Cancer

Nakao, Kazuyasu; Kurozumi, Kazushi; Fukushima, Satsuki; Nakahara, Masaaki; Tsujimoto, Masahiko; Nishida, Toshirou

doi:10.1007/s00268-001-0022-7

Cited by 40 publications

(26 citation statements)

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“…Among case series of well-differentiated thyroid cancer, lung metastases were present in 13.8% (range, 6.5% to 20.0%) of patients at the time of or prior to diagnosis (7,(25)(26)(27)(28)(29)(30)(31) and esophageal involvement in 29.0% (range, 4.9% to 62.0%) (6,25,29,(31)(32)(33)(34)(35)(36). Lung metastases were also present at or prior to secondary tracheal tumor diagnosis in patients with renal cell carcinoma (22%), rectal cancer (85%), melanoma (16.7%), esophageal cancer (3%), colon cancer (33.3%), carcinoma with thymus-like differentiation (CASTLE; 12.5%) and breast cancer (40%) ( Table S1).…”

Section: Concurrent Metastasesmentioning

confidence: 99%

“…In the literature of invasive thyroid cancer, there was one case of laryngotracheoesophagectomy with reconstruction of the digestive tract with a forearm free flap (109). There were 28 cases of circumferential tracheal and partial-thickness or partial-circumference esophageal resection with reconstruction (6,8,10,25,29) and in addition two cases of combined partial resection of trachea and esophagus (25). One series reported concomitant unspecified esophageal resection with tracheal shave (n=5), tracheal window resection (n=2) and circumferential tracheal resection with reconstruction (n=1) (31).…”

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confidence: 99%

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Secondary tracheal tumors: a systematic review

Madariaga¹,

Gaissert²

2018

Ann. Cardiothorac. Surg.

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Background: Secondary tracheal tumors arise from mural invasion by primary tumors in adjacent organs, metastatic lymph nodes or blood-born metastasis from distant sites. This systematic review aims to assess the presentation, management options, and clinical outcomes of these uncommon non-tracheal malignancies.Methods: Electronic searches of the MEDLINE database were performed to identify case series and individual case reports of tracheal invasion by primary non-tracheal tumors or metastatic disease. AllEnglish-language studies with available abstracts or articles containing primary data were included.Results: From 1978 to 2017, a total of 160 case reports or case series identified 2,242 patients with invasion of the trachea by tumors of adjacent organs (n=1,853) or by metastatic lymph nodes or hematogenous spread (n=389). Common primary sites of origin were thyroid, esophagus, and lung, and the most common presentation was metachronous (range of interval: 0 to 564 months) with dyspnea, neck mass, voice change and/or hemoptysis. A majority of patients in case reports (77.9%) and case series (66.0%) underwent resection and the most common reported operation was segmental tracheal resection. Fewer patients underwent bronchoscopic intervention (21.7%) and radiation was used in 32.2% of patients. Complications after bronchoscopic treatment included bleeding, granulation tissue, and retained secretions, while anastomotic leak, unplanned tracheostomy, and new recurrent laryngeal nerve paralysis were observed after surgical resection. The rate of 30-day mortality was low (0.01-1.80%). Median survival was higher in patients with thyroid malignancy and in patients who underwent surgical management. Follow-up time ranged from 0.03 to 183 months. Conclusions:Patients with tracheal invasion by metastatic or primary non-tracheal malignancies should be assessed for symptoms, tumor grade, tumor recurrence and concurrent metastases to decide on optimal surgical, bronchoscopic or noninterventional therapy. Clinical experience suggests that palliative endoscopic intervention for tracheal obstruction by metastasis-bearing lymph nodes is underreported.Keywords: Endotracheal metastasis; secondary tracheal tumors; systematic review Submitted Nov 24, 2017. Accepted for publication Dec 21, 2017Dec 21, . doi: 10.21037/acs.2018 View this article at: http://dx.doi.org/10.21037/acs.2018.02.01 Systematic Review IntroductionSecondary tracheal tumors are defined as tumors in, but not of the trachea and comprise a wide spectrum of tumor histologies and stages. There are no populationbased data for these tumors, and in clinical practice these lesions are probably more common than primary neoplasms. A thoracic surgeon probably encounters tracheal obstruction by metastatic lymph nodes more often than invasion by adjacent primary tumors. Since natural history and prognosis are related to the tumor of origin, their management and prognosis may differ considerably from primary tracheal neoplasms; a correct diagnosis with attribution to the origi...

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Section: Concurrent Metastasesmentioning

confidence: 99%

mentioning

confidence: 99%

Secondary tracheal tumors: a systematic review

Madariaga¹,

Gaissert²

2018

Ann. Cardiothorac. Surg.

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“…Local invasion, such as of the trachea, by thyroid carcinoma can lead to dyspnea, tracheal bleeding and dysphagia, which represent the major causes of the decreased survival of these patients [4]- [6]. There have been several Figure 4.…”

Section: Discussionmentioning

confidence: 99%

Successful Treatment of Thyroid Carcinoma Invading the Trachea as a Single-Stage Procedure: A Case Report

Endo¹,

Ueno²,

Kondo³

et al. 2015

CRCM

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Objective: Locally advanced thyroid carcinoma is relatively rare; extrathyroid extension, such as to the trachea, is one of the most important prognostic factors. Surgical resection is the mainstay of treatment, and appropriate surgical planning is crucial for obtaining a reasonable prognosis and quality of life of the patients. Case Report: Herein, we report a case of advanced thyroid carcinoma involving the trachea. Total thyroidectomy and window resection of the trachea were performed. The tracheal defect was approximately 2.5 × 3.0 cm in size, extending from the first to the third tracheal cartilage, and was reconstructed with auricular cartilage and covered with the sternohyoid muscles of both sides in a single-stage surgical procedure. The tracheal stoma was closed 2 weeks after the surgery. There were no postoperative complications. Conclusion: This reconstruction of the relatively small defect of the trachea provided excellent functional and cosmetic results.

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“…Salvage resections should therefore be performed in selected cases only [32]. Local radical thyroidectomy with combined resection of the trachea can serve as a useful treatment for advanced differentiated cancer invading the airway [33].…”

Section: Thyroidmentioning

confidence: 99%

Site-wise Differences in Adequacy of the Surgical resection Margins in Head and Neck Cancers

Vidhyadharan

Augustine

Kudpaje

et al. 2014

Indian J Surg Oncol

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Adequacy of surgical resection decided by the margin status is important in attaining a good local control and better survival in Head and neck Cancers. Conventionally, a measured distance between the tumor edge and the cut edge of the specimen is taken as the margin. A margin more than 5 millimeter (mm) is considered clear, less than 5 mm is close and less than one mm is denoted as involved. The concept of this adequacy varies between the different sites and subsites in head and neck. The purpose of this paper is to review the current evidence that describes the adequacy of surgical margin status and their variability among the sites and sub-sites in the head and neck.

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Merits and Demerits of Operative Procedure to the Trachea in Patients with Differentiated Thyroid Cancer

Cited by 40 publications

References 10 publications

Secondary tracheal tumors: a systematic review

Secondary tracheal tumors: a systematic review

Successful Treatment of Thyroid Carcinoma Invading the Trachea as a Single-Stage Procedure: A Case Report

Site-wise Differences in Adequacy of the Surgical resection Margins in Head and Neck Cancers

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