Merits of prophylactic sclerotherapy for esophageal varices concomitant unresectable hepatocellular carcinoma: Prospective randomized study

Akahoshi, Tomohiko; Tomikawa, Morimasa; Tsutsumi, Norifumi; Hashizume, Makoto; Maehara, Yoshihiko

doi:10.1111/den.12119

Cited by 7 publications

(4 citation statements)

References 31 publications

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“…However, there have been no reports regarding the risk factors for EV bleeding after hepatectomy in patients with HCC. The current treatment strategy for EV is based on the finding that endoscopic sclerotherapy prevents EV bleeding in patients with PHT [24][25][26]. High-risk varices may bleed as a result of increased portal venous pressure after hepatic resection, associated with Pringle's maneuver or major hepatectomy.…”

Section: Discussionmentioning

confidence: 99%

“…Miyoshi et al reported 3‐year bleeding rates of 50 % for the control group and 18 % for the prophylactic sclerotherapy group in patients with unresectable HCC and concomitant EV [23]. Akahoshi et al reported a cumulative bleeding rate of 48.8 % at 6 months in patients with unresectable HCC and EVs that were likely to bleed, who were treated conservatively [24].…”

Section: Discussionmentioning

confidence: 99%

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Surgical Resection for Hepatocellular Carcinoma with Concomitant Esophageal Varices

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Surgical Resection for Hepatocellular Carcinoma with Concomitant Esophageal Varices

et al. 2015

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“…MELD score was statistically significantly larger in group III than in group I and II. Recent research, however, have failed to find any link among sexuality as well as EVs (10) . In addition, there was a link among the size of EVs as well as the age of the individual, with larger EVs being linked to older patients and smaller EV being linked to younger cases.…”

Section: Discussionmentioning

confidence: 95%

Simple Predictors of Gastro Esophageal Varices Bleeding in Cirrhotic Patients

2023

The Egyptian Journal of Hospital Medicine

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Background: Liver stiffness (LS), measured by transient elastography (TE), was correlated with portal hypertension as well as the presence of esophageal varices (EV). Objective: The aim of the current study was to examine non-invasive markers that serve as "predictors" of esophageal varices (EV) and variceal hemorrhage in individuals with liver cirrhosis. Patients and methods: A total of 250 Egyptian HCV associated cirrhotic persons, age more than 18, body mass index (BMI) under 35 with no history of ascites, GIT bleeding, HCC, abdominal collaterals, Portal, or splenic vein thrombosis by ultrasonography were recruited in our study. They were divided into Group I (no varices), Group II (small varices) and Group III (large varices). Results: All groups were age and BMI matched, in group III platelet count was lower and MELD score was higher significantly than groups I and II (115.4±41.6 vs 149.6±60.6 and 132.1±44.9) and (12.1±2.9 vs 9.1+2.5 and 10.1+2.2) respectively. Hemoglobin, platelet count and serum albumin were significantly decreased in group III in comparison with groups I and II (P-value <0.001), while serum bilirubin and INR levels were significantly more in group III than in groups I and II (P-value <0.001). AFP was significantly increased in group II than groups I and III (P-value 0.008). Conclusion:Our findings demonstrate the potential for using predictors to stratify cirrhotic individuals for the likelihood of developing extensive EV, hence enhancing the cost-effectiveness of screening endoscopy.

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“…One possible explanation is that liver disease in men is more severe and carries a higher risk of complications and death than in women. However, several recent research have failed to find a correlation between gender and esophageal varices (9) . Additionally, there was a correlation between the size of the esophageal varices and the patient's age, with larger OV being linked to elderly patients and smaller OV to younger persons.…”

Section: Discussionmentioning

confidence: 99%

Fibroscan in Grading and Prediction of the Risk of Bleeding of Gastro-Esophageal Varices in HCV related Cirrhotic Patients

Omar,

Salama,

Saad

et al. 2023

The Egyptian Journal of Hospital Medicine

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Background: By measuring liver stiffness (LS) with transient elastography (TE), portal hypertension and the presence of oesophageal varices (OV) were investigated. In HCV-related cirrhotic individuals, fibroscan is capable of predicting the presence of esophageal varices. And probable categorization based on degree of hepatic rigidity.Objective: This research aimed to use fibroscan and a prospective grade based on degree of liver stiffness as a means of diagnosing esophageal varices earlier in people with cirrhosis caused by HCV. Methods: Ultrasonography was used to evaluate 250 Egyptian HCV-related cirrhotic patients, aged >18, with a BMI of < 35 and no history of ascites, GIT hemorrhage, HCC, abdominal collaterals, portal or splenic vein thrombosis. They classified the varices as group I (no varices), group II (little varices), and group III (big varices). Results: All Groups were matched for age and BMI. In group III, Platelet count was lower & MELD was higher significantly than in groups I &

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Merits of prophylactic sclerotherapy for esophageal varices concomitant unresectable hepatocellular carcinoma: Prospective randomized study

Abstract: This prospective study demonstrated that prophylactic EIS could prolong the survival of the patients with esophageal varices concomitant with unresectable HCC. Prophylactic EIS for patients with unresectable HCC may be, in part, justified according to the present study.

Cited by 7 publications

References 31 publications

Surgical Resection for Hepatocellular Carcinoma with Concomitant Esophageal Varices

Surgical Resection for Hepatocellular Carcinoma with Concomitant Esophageal Varices

Simple Predictors of Gastro Esophageal Varices Bleeding in Cirrhotic Patients

Fibroscan in Grading and Prediction of the Risk of Bleeding of Gastro-Esophageal Varices in HCV related Cirrhotic Patients

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