Merkel Cell Carcinoma and Immunosuppression, UV Radiation, and Merkel Cell Polyomavirus
Jacob T. Tribble,
Ruth M. Pfeiffer,
Isaac Brownell
et al.
Abstract:ImportanceMerkel cell carcinoma (MCC) is a rare but aggressive skin cancer. Quantifying the contribution of major potentially modifiable risk factors to the burden of MCC may inform prevention efforts.ObjectiveTo estimate the population attributable fraction of MCC cases in the US that were attributable to major immunosuppressing conditions (eg, HIV, solid organ transplant, chronic lymphocytic leukemia [CLL]), ambient UV radiation [UVR] exposure, and Merkel cell polyomavirus [MCPyV]).Design, Setting, and Parti… Show more
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