Merkel cell carcinoma expresses K homology domain–containing protein overexpressed in cancer similar to other high-grade neuroendocrine carcinomas

Pryor, Jennifer G.; Simon, Rebecca; Bourne, Patricia A.; Spaulding, Betsy O.; Scott, Glynis; Xu, Haodong

doi:10.1016/j.humpath.2008.07.009

Cited by 22 publications

(19 citation statements)

References 31 publications

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“…IMP3 is expressed in malignant melanoma but not in benign nevi, even when dysplastic features are present and it is expressed in metastatic melanomas significantly more often than in early-stage melanomas [20]. In neuroendocrine carcinomas, IMP3 seems to be a marker for high-grade tumors as it is frequently found in extrapulmonary small cell carcinomas (89% positive), small cell lung carcinomas (90% positive), large cell neuroendocrine carcinomas of the lung (64% positive), and Merkel cell carcinomas (90% positive), whereas it is negative in pulmonary and extrapulmonary carcinoid tumors [21][22][23]. IMP3 is a promising new marker with high specificity and sensitivity for pancreatic adenocarcinomas in pancreatic fine needle aspirates [24,25].…”

Section: Discussionmentioning

confidence: 99%

IMP3 expression in lesions of the biliary tract: a marker for high-grade dysplasia and an independent prognostic factor in bile duct carcinomas

Riener¹,

Fritzsche²,

Clavien³

et al. 2009

Human Pathology

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Section: Discussionmentioning

confidence: 99%

IMP3 expression in lesions of the biliary tract: a marker for high-grade dysplasia and an independent prognostic factor in bile duct carcinomas

Riener¹,

Fritzsche²,

Clavien³

et al. 2009

Human Pathology

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“…IMP3 is considered an oncofetal protein that is expressed in fetal and carcinogenic tissue; however, the exact function of IMP3 remains unknown (7)(8)(9)(10)(11)(12). Expression of IMP3 has been studied in a wide variety of cancers, including renal cell carcinoma (13,14), adenocarcinoma of the uterine cervix (15), endometrial carcinoma (16), adenocarcinoma of the esophagus (17), malignant melanoma (18), Merkel cell carcinoma (19), urothelial carcinoma (20), neuroendocrine carcinoma of the lung (21), gastric adenocarcinoma (22), hepatocellular carcinoma (23), pancreatic (24)(25)(26)(27) and biliary tract (27) adenocarcinoma, and triple negative breast cancer (28), where this marker has frequently been associated with enhanced tumor aggressiveness and a worse outcome.…”

Section: Introductionmentioning

confidence: 99%

IMP3 and p16 expression in squamous cell carcinoma of the head and neck: A comparative immunohistochemical analysis

et al. 2017

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Abstract. Expression of p16 has been established as a good surrogate marker for high-risk human papillomavirus (HPV) infection in oropharyngeal squamous cell carcinoma (OPSCC) patients, and it has been associated with an improved prognosis, irrespective of the actual HPV status. Conversely, the human insulin-like growth factor II mRNA binding protein 3 (IMP3) has been related to aggressiveness in several types of tumors. The aim of the present study was to investigate and compare p16 and IMP3 as markers of favorable and unfavorable behavior, respectively, in head and neck SCC (HNSCC), with particular reference to the HPV status. Both markers were analyzed by immunohistochemical analysis of 156 HNSCC samples originating from the oropharynx (n=81), oral cavity (n=44), larynx (n=15), hypopharynx (n=10) and nasopharynx (n=6). The HPV status was examined in a randomly selected representative subcohort (n=38) using polymerase chain reaction. Of the 156 HNSCC samples, 81 (51.9%) and 54 (34.6%) were positive for IMP3 and p16, respectively. IMP3 expression (P=0.022), p16 expression (P<0.001) and the combination of these markers (P<0.001) were significantly associated with tumor site. In particular, 69/81 (85%) OPSCC samples were positive for either one or both markers compared with 36/75 (48%) SCC samples from other sites. p16 expression was significantly associated with HPV infection (P= 0.017) and a trend towards a negative association between IMP3 expression and HPV infection was observed (P=0.053). The results of the present study suggested that IMP3 and p16 are more frequently expressed in OPSCC compared with other HNSCCs. The prognostic impact of IMP3 on OPSCC remains to be investigated in a larger series with an extended follow-up period. IntroductionSquamous cell carcinoma (SCC) is the leading cancer type affecting the head and neck region (HNSCC) representing >90% of malignant neoplasms of the oral cavity and oropharynx and 5 and 2% of all cancers in men and women, respectively (1). Tobacco smoking and alcohol consumption are the two major etiological factors of HNSCC and they work in a synergistic manner to initiate SCC (1). Approximately 75% of HNSCC cases in western countries are related to these two major risk factors, while the remainder is predominantly associated with viral infection, in particular infection with high-risk human papillomavirus (HPV) (1). HPV has been detected in a small fraction of oral cavity SCCs, and in 40-50% of oropharyngeal (mainly tonsillar) SCC (OPSCC) (1). While HPV-associated HNSCC may occur at any site, including the sinonasal tract, the majority of HPV-related SCCs originate in the lymphoid tissue bearing the oropharynx, mainly the palatine tonsil and the base of the tongue (1). Expression of p16 as a consequence of oncogenic HPV infection has been increasingly used as a surrogate marker for high-risk HPV infection, particularly in the female genital tract and the oropharynx (2,3). The sensitivity and specificity of p16 immunostaining for detecting high-risk HPV in OPSCC patie...

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“…High levels of IMP3 expression have been reported to have diagnostic and/or prognostic value in different malignant tumors (kidney, ovary, liver, endometrium, esophagus, biliary tract, bladder, uterine cervix, stomach, colonrectum, esophagus, lung, exocrine pancreas, thyroid, ovary, testis, bone, and skin) [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] (Table 2). Our results confirmed the expression of IMP3 in the normal pituitary tissues, previously reported, using immunohistochemical, Western blotting, and RT-PCR analyses.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have shown that IMP3 is associated with aggressive and advanced carcinomas in colon, kidney, neuroendocrine skin (Merkel cell carcinoma), liver, bladder, ovary, and in soft tissue sarcomas [16][17][18][19][20][21][22][23][24][25]. On the basis of these results, IMP3 may be a useful prognostic factor in many malignant solid tumors.…”

Section: Introductionmentioning

confidence: 99%

Analysis of IMP3 Expression in Normal and Neoplastic Human Pituitary Tissues

et al. 2009

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Insulin-like growth factor II mRNA-binding protein 3 (IMP3) is an oncofetal protein highly expressed in fetal tissue and malignant tumors but rarely found in adult benign tissues. In various tumors, IMP3 expression is correlated with increased tumor aggressiveness and reduced overall survival. To our knowledge, IMP3 expression has not been investigated in pituitary tumors. We analyzed the immunohistochemical expression of IMP3 in five normal pituitary tissues and 75 pituitary tumors (64 adenomas and 11 carcinomas) to determine if specific tumor types expressed IMP3 and if there were differences in IMP3 expression between adenomas and carcinomas. Immunohistochemical analysis showed that IMP3 was positive in four (80%) normal pituitaries with focal stain in a subset of normal anterior pituitary cells. IMP3 was expressed in 31% (20/64) of adenomas and in 36% (4/11) of carcinomas. A slightly higher level of IMP3 expression was observed in PRL-GH-TSH adenomas compared to the other types of pituitary adenomas. Expression of IMP3 was not significantly higher in carcinomas than in adenomas (p = 0.737). RT-PCR and Western Blotting supported the heterogeneous expression of IMP3. These results indicate that IMP3 is expressed both in normal and in neoplastic pituitary gland tissues without significant differences in expression levels in pituitary carcinomas.

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Merkel cell carcinoma expresses K homology domain–containing protein overexpressed in cancer similar to other high-grade neuroendocrine carcinomas

Cited by 22 publications

References 31 publications

IMP3 expression in lesions of the biliary tract: a marker for high-grade dysplasia and an independent prognostic factor in bile duct carcinomas

IMP3 expression in lesions of the biliary tract: a marker for high-grade dysplasia and an independent prognostic factor in bile duct carcinomas

IMP3 and p16 expression in squamous cell carcinoma of the head and neck: A comparative immunohistochemical analysis

Analysis of IMP3 Expression in Normal and Neoplastic Human Pituitary Tissues

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