Merkel cell carcinoma of the anorectum: a case report and review of the literature

Wyk, Abraham Christoffel van; Moolla, Zaheer; Motala, Ahmed I; Roberts, Riyaadh; Chotey, Nivesh A; Lakhi, Hoosen I; Becker, Jürgen C.

doi:10.1007/s12328-022-01648-y

Clin J Gastroenterol

2022

DOI: 10.1007/s12328-022-01648-y

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Merkel cell carcinoma of the anorectum: a case report and review of the literature

Abraham Christoffel van Wyk

Zaheer Moolla

Ahmed I Motala³

et al.

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2024

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Cited by 1 publication

References 30 publications

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Merkel Cell Carcinoma With Extensive Bone Marrow Metastasis and Peripheral Blood Involvement: A Case Report With Immunohistochemical and Mutational Studies

Highland,

Morrow,

Arispe

et al. 2024

Applied Immunohistochemistry &Amp; Molecular Morphology

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Merkel cell carcinoma (MCC) is a rare, highly aggressive skin cancer of neuroendocrine origin that is typically associated with either the presence of Merkel cell polyomavirus or chronic exposure to ultraviolet (UV) light. We report a case of relapsed MCC that presented with new symptoms of fatigue, back pain, and myeloid left shift identified during scheduled follow-up. The patient was found to have circulating neoplastic cells in the peripheral blood and bone marrow metastasis. Immunohistochemistry for synaptophysin, CD56, INSM-1, CK20, CD117 were positive, whereas CD34, TdT, Chromogranin, CD10, myeloperoxidase, CD3 and CD19 were negative. Flow cytometry of the peripheral blood confirmed the presence of an abnormal nonhematopoietic cell population expressing CD56 positivity. A next-generation sequencing (NGS) panel revealed the presence of variants in RB1, TP53, and other genes, some of which have not been previously described in MCC. This rare presentation highlights the challenges in the diagnosis and management of MCC.

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Merkel Cell Carcinoma With Extensive Bone Marrow Metastasis and Peripheral Blood Involvement: A Case Report With Immunohistochemical and Mutational Studies

Highland,

Morrow,

Arispe

et al. 2024

Applied Immunohistochemistry &Amp; Molecular Morphology

View full text Add to dashboard Cite

show abstract

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Merkel cell carcinoma of the anorectum: a case report and review of the literature

Cited by 1 publication

References 30 publications

Merkel Cell Carcinoma With Extensive Bone Marrow Metastasis and Peripheral Blood Involvement: A Case Report With Immunohistochemical and Mutational Studies

Merkel Cell Carcinoma With Extensive Bone Marrow Metastasis and Peripheral Blood Involvement: A Case Report With Immunohistochemical and Mutational Studies

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