Merkel Cell Carcinoma of the Eyelid and Periocular Region

Merritt, Helen; Sniegowski, Matthew; Esmaeli, Bita

doi:10.3390/cancers6021128

Cited by 29 publications

(19 citation statements)

References 40 publications

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“…Positive immunohistochemical staining for neuron-specific enolase, neurofilaments, protein and cytokeratin-20, and negative for S-100 and leukocyte-common antigen are helpful for differentiation from similarly appearing epithelial and neuroendocrine tumors. [ 46 ]…”

Section: Neurogenic Tumorsmentioning

confidence: 99%

Pathology of eyelid tumors

Pe’er

2016

Indian J Ophthalmol

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The eyelids are composed of four layers: skin and subcutaneous tissue including its adnexa, striated muscle, tarsus with the meibomian glands, and the palpebral conjunctiva. Benign and malignant tumors can arise from each of the eyelid layers. Most eyelid tumors are of cutaneous origin, mostly epidermal, which can be divided into epithelial and melanocytic tumors. Benign epithelial lesions, cystic lesions, and benign melanocytic lesions are very common. The most common malignant eyelid tumors are basal cell carcinoma in Caucasians and sebaceous gland carcinoma in Asians. Adnexal and stromal tumors are less frequent. The present review describes the more important eyelid tumors according to the following groups: Benign and malignant epithelial tumors, benign and malignant melanocytic tumors, benign and malignant adnexal tumors, stromal eyelid tumors, lymphoproliferative and metastatic tumors, other rare eyelid tumors, and inflammatory and infections lesions that simulate neoplasms.

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Section: Neurogenic Tumorsmentioning

confidence: 99%

Pathology of eyelid tumors

Pe’er

2016

Indian J Ophthalmol

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“…Evidence clearly outlining a role for SLNB in periocular MCC is largely lacking, nevertheless, implications from the general MCC literature, periocular-specific studies, and case reports such as ours, are relevant and worth consideration. Collectively, this data, and now the development of new, risk-stratified, treatment options help explain why multiple authors, ourselves included, continue to advocate that SLNB be strongly considered, [ 33 ] if not recommended, [ 30 ] for all periocular MCC and regardless of size.…”

Section: Discussionmentioning

confidence: 99%

Sentinel lymph node biopsy in periocular merkel cell carcinoma: a case report

2017

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BackgroundThe National Comprehensive Cancer Network guidelines for Merkel cell carcinoma recommend performance of the sentinel lymph node biopsy in all patients with clinically negative nodal disease for staging and treatment. Nevertheless, sentinel lymph node biopsy in the periocular region is debated as tumors are typically smaller and lymphatic variability can make performance procedurally problematic.Case presentationWe present a case of a Caucasian patient in their seventies who presented with a 1.0 cm periocular Merkel cell carcinoma, who underwent Mohs surgery with a Tenzel flap repair, that was found to have a positive sentinel lymph node biopsy, but who, despite parotidectomy, selective neck dissection, and radiation, succumbed to the disease.ConclusionsEvidence in both the site-specific and non-specific literature demonstrates: (1) Worsening prognosis with extent of lymph node burden, (2) improvements in our abilities to perform lymphoscintigraphy, (3) locoregional and distant metastatic disease in patients with tumor sizes ≤1 cm, and (4) significant rates of sentinel lymph node positivity in patients with tumor sizes ≤1 cm. Our case supports that sentinel lymph node biopsy should be considered in all clinically nodal negative periocular Merkel cell carcinoma, regardless of size, and despite limited site-specific studies on the subject.

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“…Lesión ubicada con mayor frecuencia en párpado inferior y canto medial, de crecimiento lento y con capacidad de recurrencia baja Otras patologías que también pueden requerir un diagnóstico diferencial del CBPO son el sarcoma de Kaposi, el linfoma, el melanoma amelanótico (15), el chalazión, el molusco contagioso, el papiloma y la blefaritis marginal (59)(60)(61)(62)(63)(64).…”

Section: Diagnóstico Diferencialunclassified

Actualización en carcinoma basocelular periocular: abordaje semiológico y diagnóstico diferencial

Nieto¹,

Patiño²,

Estepa³

2019

Cienc. Tecnol. Salud Vis. Ocul.

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Introducción: este artículo se basa en la revisión y profundización de conceptos actuales rela¬cionados con la semiología clínica y el diagnóstico diferencial, referentes al carcinoma basoce¬lular periocular (CBPO). Objetivo: describir las características semiológicas y los diagnósticos diferenciales del CBPO. Metodología: se realizó una revisión de literatura en las bases de datos ScienceDirect, BVS, Pubmed, SciELO y EBSCO/Medline, mediante los términos MeSH y DeCS “carcinoma”, “basal cell” y “carcinoma basocelular”, con el operador booleano “and” y el término “periocular”, en el periodo 2012-2018. Según el total de estudios relacionados con los términos de la búsqueda, fueron seleccionados artículos escritos en francés, inglés, alemán y español. La calidad de la evidencia científica fue clasificada a través de la metodología de Oxford. Resultados: se describieron las características semiológicas del CBPO y sus diagnósticos diferenciales mediante un flujograma, que permite realizar su identificación clínica. Conclu¬sión: el CBPO es la neoplasia maligna más común del párpado y podría catalogarse, debido a su alta incidencia, como una primera impresión diagnóstica ante la identificación de neoplasias malignas palpebrales. Su detección temprana y el control ante posibles recidivas conforman un objetivo principal del diagnóstico y la prevención en la praxis clínica.

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Merkel Cell Carcinoma of the Eyelid and Periocular Region

Cited by 29 publications

References 40 publications

Pathology of eyelid tumors

Pathology of eyelid tumors

Sentinel lymph node biopsy in periocular merkel cell carcinoma: a case report

Actualización en carcinoma basocelular periocular: abordaje semiológico y diagnóstico diferencial

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