Merkel cell carcinoma of the eyelid: histological and immunohistochemical features with special respect to differential diagnosis

Metz, K.; Jacob, Michael; Schmidt, Ulrich; Steuhl, Klaus‐Peter; Leder, L. D.

doi:10.1007/s004170050121

Cited by 62 publications

(40 citation statements)

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“…Our findings did not support those of others who have documented that 20% of lesions were located in the eyelid or perioral region. 28,29 We added one additional patient with MCC of unknown primary site to the few documented cases already in the literature. [30][31][32][33] MCC without a primary tumor location can be a diagnostic dilemma for the surgical pathologist because of its histologic similarities with poorly differentiated small cell and other neuroendocrine carcinomas.…”

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confidence: 99%

Merkel cell carcinoma of the head and neck: A retrospective case series

et al. 2002

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Merkel cell carcinoma of the head and neck: A retrospective case series

et al. 2002

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“…The growth pattern of that tumor resembles that of a Merkel cell tumor. Cytokeratin 20 was usually negative while thyroid transcription factor was positive in such small cell carcinomas, but there has been no equivalent report on animals [6,[9][10][11]. In our case, as necropsy was not performed, a metastatic neuroendocrine tumor including small cell carcinoma of lung, could not be completely excluded.…”

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confidence: 61%

“…It has been reported that an immunohistochemical examination using cytokeratin 20 is extremely useful in distinguishing Merkel cell tumors from trichoblastoma and sweat gland tumors [11]. Merkel cell tumors are characterized by perinuclear dot-like structures (keratin button) for cytokeratin 20 [10,11], but these pattern is not universally seen as is true of those in the present case [7].…”

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confidence: 76%

“…However, negative staining for cytokeratin 8/18 served to exclude sweat gland differentiation. Moreover, the morphologic pattern of immunohistochemical positivity for cytokeratin 20 was very characteristic and indicative of Merkel cell tumor [10]. It has been reported that an immunohistochemical examination using cytokeratin 20 is extremely useful in distinguishing Merkel cell tumors from trichoblastoma and sweat gland tumors [11].…”

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Merkel Cell Carcinoma in a Cat

Ozaki

Narama

2009

The Journal of Veterinary Medical Science

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ABSTRACT. A 17-year-old spayed female Japanese domestic cat presented with a solitary cutaneous mass in the right thoracic area. Histopathologically, the mass consisted mainly of round tumor cells that had infiltrated throughout the dermis and deep subcutaneous tissue. The proliferating pattern of tumor cells was solid but also trabecular or cord-like in some areas, and lined with small cells resembling mature lymphocytes or basal cells. The tumor cells were positive for cytokeratin 20 and synaptophysin. The positive reaction for cytokeratin 20 showed localized to diffuse pattern. This is the first report describing now cytokeratin 20 was clearly beneficial for the differential diagnosis of feline Merkel cell carcinoma.KEY WORDS: cytokeratin 20, feline, Merkel cell carcinoma, neuroendocrine tumor.

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“…Another epithelial marker which controls the determination and differentiation of cells is thyroid transcription factor 1 (TTF -1), consisting of epithelial cells of the thyroid gland, lung and One standard marker used in the diagnosis of neuroendocrine tumors is neuron-specific enolase (NSE) (ref. 22,23 ). More recently, markers used in the diagnosis of MCC are CD56 and NCAM (neural cell adhesion molecule) (ref.…”

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Merkel cell carcinoma. A review

Pink¹,

Ehrmann²,

Molitor³

et al. 2012

BIOMED PAP

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Background. Merkel cell carcinoma (MCC) is a rare potentially fatal skin tumour affecting older mainly white people and younger immunosuppressed individuals. While uncommon, the incidence is increasing relative to melanoma and with twice the lethality. The benign appearance of the tumour usually on exposed skin parts, contrasting with its extensive microscopic invasion, can delay timely diagnosis. Recurrent MCC is currently attributed to the recently discovered Merkel cell polyomavirus This brief review of MCC covers the history, epidemiology,etiology,clinical and histological features, treatment and prognosis. Methods. Literature search using PubMed and search words Merkel cell carcinoma (MCC), etiology, treatment for the years 1972 to 2010. Results and conclusion. Merkel cell carcinoma is a rare malignancy with uncertain prognosis. Due to the uncommon occurrence and dearth of randomized studies, there is no agreement on optimal treatment. The tumor has only recently been included in the international classification of tumors (NCCN). The treatment approaches found to be best are radical surgery of primary tumor, drainage of lymph node extension and possibly adjuvant loco-regional radiotherapy. The basis of successful treatment however, remains prevention regular dermatological examination in immunosuppressed patients and early initiation of combination therapy, based on radical surgery supplemented by radiotherapy and palliative chemotherapy in the last resort.

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Merkel cell carcinoma of the eyelid: histological and immunohistochemical features with special respect to differential diagnosis

Cited by 62 publications

References 29 publications

Merkel cell carcinoma of the head and neck: A retrospective case series

Merkel cell carcinoma of the head and neck: A retrospective case series

Merkel Cell Carcinoma in a Cat

Merkel cell carcinoma. A review

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